Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (4): 15-21.doi: 10.6040/j.issn.1673-3770.0.2023.083

• Original Article • Previous Articles    

Comparative analysis of speech recognition ability before and after treatment of intractable sudden deafness using retroaural injection of ganglioside and intratympanic injection of methylprednisolone

CAO Ying1, QIU Yue1, CHEN Zhibin2, FEI Bing1, LI Dong1, ZHANG Xiaofeng3,WANG Hui4,KANG Xinle5, WANG Haixu1,HUAI De1,LI Xiuting6, SHU Mingyang7   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, Huai'an Second People's Hospital, Huai'an 223002, Jiangsu, China2. Department of Otorhinolaryngology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu, China3. Department of Pharmacy, Huai'an Second People's Hospital, Huai'an 223002, Jiangsu, China4. Department of Nursing, Huai'an Second People's Hospital, Huai'an 223002, Jiangsu, China5. Department of Ophthalmology, Huai'an Second People's hospital, Huai'an 223002, Jiangsu, China6. Jiangsu Health Vocational College, School of Public Health Administration, Nanjing 210000, Jiangsu, China7. Department of Stomatology, Huai'an Second People's hospital, Huai'an 223002, Jiangsu, China
  • Published:2024-07-09

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Abstract: Objective This study aimed to analyze the impact of postauricular injection of ganglioside combined with intratympanic injection of methylprednisolone on word recognition score(WRS)and its influencing factors in patients with unilateral refractory sudden deafness. Methods This study included 58 patients with refractory sudden deafness who were treated with postauricular ganglioside injection combined with intratympanic methylprednisolone injection. Data was collected on the patients' age, sex, disease duration, ear category, concomitant symptoms, and pure tone audiometry(PTA)and speech audiometry results pre- and post-treatment. The PTA results and the maximum speech recognition rate(WRSmax)were statistically analyzed pre- and post-treatment. Logistic regression analysis was applied to identify factors that improve WRS. Results Patients with refractory sudden deafness showed significant improvements in PTA and WRS in the affected ear after treatment(P=0.027,P=0.038). Furthermore, a negative correlation was observed between PTA and WRS(r=-0.682, P<0.05). Univariate analysis revealed that age, sex, precipitating factors, affected ear, concomitant symptoms, and WRS were not significantly correlated(P=0.693, P=0.208,P=0.079, P=0.335, P=0.331)), and the differences were not statistically significant. However, time from onset to the first visit, degree of hearing damage, and type of hearing curve were identified as important factors that influenced improvement in WRS(P=0.010, P=0.033, P=0.026). Conclusion Administration of postauricular ganglioside combined with intratympanic methylprednisolone resulted in a 41.38% improvement in WRS for patients with refractory sudden deafness. Improvement in WRS was also influenced by the time from onset to the first visit, degree of hearing impairment, and type of hearing curve. The improvement in WRS was significantly worse in those with a longer time from onset to first visit than in those with a shorter duration; however, it was significantly better in those with low-frequency hearing loss than in those with flat and high-frequency hearing loss after treatment with the aforementioned methods. The severity of hearing impairment negatively impacted improvement in WRS.

Key words: Refractory idiopathic sudden sensorineural hearing loss, Intratympanic and postauricular injection, Word recognition score, Pure-tone average

CLC Number: 

  • R764.5
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