Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (6): 66-70.doi: 10.6040/j.issn.1673-3770.0.2024.073

• Clinical Research • Previous Articles    

Expression analysis of pepsin in vocal cord leukoplakia tissues

NIU Yanyan, GU Wei, JIN Xiaofeng, HUO Hong, YANG Dahai, CUI Tingting, WANG Jian   

  1. Department of Otolaryngology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
  • Published:2024-12-13

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Abstract: Objective To investigate the expression of pepsin in different pathological types of vocal cord leukoplakia tissues and to explore the relationship between vocal cord leukoplakia and laryngopharyngeal reflux(LPR), providing evidence for the prevention and treatment of vocal cord leukoplakia. Methods Clinical data of 71 patients with vocal cord leukoplakia were retrospectively analyzed. Immunohistochemical staining was used to analyze the expression of pepsin in vocal cord leukoplakia tissues. Multivariate analysis was performed to clarify the relationship between laryngopharyngeal reflux and vocal cord leukoplakia. Results Among the 71 patients, there were 63 males and 8 females. The age ranged from 40 to 75 years with a mean age of 58.6±8.6 years. The proportions of positive pepsin staining in the low-grade dysplasia group and the high-grade dysplasia group of vocal cord leukoplakia were 23.4%(11/47)and 75%(18/24), respectively, with statistical significance. After adjustment for possible risk factors such as age, gender, smoking and alcohol consumption, positive pepsin expression also increased the risk of high-grade dysplasia with an odds ratio of 9.64(95%CI:2.96-31.38). Conclusion Pepsin, as a biomarker of LPR, is an independent risk factor for high-grade dysplasia of vocal cord leukoplakia. LPR may be one of the potential risk factors for high-grade dysplasia of vocal cord leukoplakia.

Key words: Laryngopharyngeal reflux, Vocal cord leukoplakia, Low-grade dysplasia, High-grade dysplasia, Pepsin

CLC Number: 

  • R766.5
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