Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (6): 23-29.doi: 10.6040/j.issn.1673-3770.0.2023.489

• Research Progress • Previous Articles    

Role of pharyngeal reflux in common respiratory diseases

ZHANG Li, ZHANG Mengru, Alimire Aierken, QIU Zhongmin   

  1. Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China
  • Published:2024-12-13

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Abstract: Laryngopharyngeal reflux(LPR)is an extraesophageal manifestation of gastroesophageal reflux disease(GERD), involving multiple disciplines, with variable and nonspecific clinical presentations, and its exact pathogenesis remains unclear. The gastrointestinal tract(stomach, oesophagus, etc.)is adjacent to the respiratory tract, sharing a common foregut embryonic origin and vagal innervation. The two are closely linked by the oesophago-tracheobronchial or tracheobronchial-esophageal reflex and influence each other. LPR is a potential precipitating factor for upper and lower airway inflammation and is associated with several respiratory diseases(e.g. chronic cough, chronic rhinosinusitis, asthma, obstructive sleep apnoea-hypopnoea syndrome, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis). In clinical practice, the management of patients with respiratory diseases associated with LPR should consider a combination of therapeutic approaches to provide individualized treatment plans for patients. This article provides an overview of the role of LPR in common respiratory diseases.

Key words: Laryngopharyngeal reflux, Gastroesophageal reflux, Vagal nerve, Respiratory tract, Anti-reflux

CLC Number: 

  • R766.5
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