m6A识别蛋白IGF2BPs家族在头颈肿瘤中的研究进展

doi:10.6040/j.issn.1673-3770.0.2024.240

Abstract

Abstract: RNA epigenetic modifications play a crucial role in tumor development, with N6-methyladenosine being the primary epigenetic modification found in all eukaryotic messenger RNAs. Recently discovered, the m6A reader family known as IGF2BPs targets GG(m6A)C sequences and enhances mRNA stability, thereby promoting tumor cell proliferation, invasion and migration, and contributing to tumorigenesis and development. This paper aims to review the involvement of IGF2BPs in head and neck tumors along with their underlying mechanisms, providing new insights for clinical molecular targeting therapy on IGF2BPs.

Key words: N6-methyladenos, Insulin-like growth factor-2 mRNA-binding protein 1, Head and neck squamous cell carcinoma, Nasopharyngeal carcinoma, Oral squamous cell carcinoma, Laryngeal squamous cell carcinoma, Hypopharyngeal cancer, Esophageal squamous-cell carcinoma, Thyroid cancer

CLC Number:

R762

YANG Ming, LIU Xuexia, ZHANG Hua. Progress of m6A recognition protein IGF2BPs in head and neck cancer[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 153-161.

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Progress of m6A recognition protein IGF2BPs in head and neck cancer

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[11]	ZHANG Yonghong, ZHANG Hui, WANG Caihua, YANG Xinxin, WU Yungang, ZHAO Yufeng, PANG Taizhong, LI Xiaoyu. Construction of an immune-associated gene prognostic model and screening of targeted molecular drugs for laryngeal squamous cell carcinoma based on the TCGA database [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 54-62.
[12]	ZHOU Yijing, ZOU Jianyin, YI Hongliang, WU Hongmin. Expression of TGFBI in head and neck squamous cell carcinoma and its clinical significance [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 85-95.
[13]	TU Qiaoling, LI Yufeng, PENG Jun. Advances in anti-PD-L1/PD-1 therapy and non-coding RNA regulation in nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 135-141.
[14]	YANG Yingling, GOU Haocheng, FENG Jun. Review of pyroptosis molecular mechanism and applications in head and neck squamous cell carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(4): 160-165.
[15]	SUO Anqi, YANG Xinxin. Research progress on the relationship between mitochondrial autophagy and squamous cell carcinoma of the head and neck [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(3): 111-117.