中性粒淋巴细胞比值与成年人听力损失及听力阈值的关系:基于NHANES数据库的横断面研究

doi:10.6040/j.issn.1673-3770.0.2025.206

Abstract

Abstract: Objective To investigate the association between the neutrophil-to-lymphocyte ratio(NLR)and hearing loss, as well as the average thresholds of low-, speech-and high-frequency pure-tone average(PTA), in adults. It is based on data from the National Health and Nutrition Examination Survey from 2005-2010 and 2015-2018. Methods A cross-sectional study design was adopted to include data from the eligible adult population. Multiple logistic regression analysis was employed to evaluate the association between NLR and hearing loss. Multiple linear regression analysis was used to evaluate the association between NLR and low-frequency, speech-and high-frequency PTA. Smoothing curve fitting was employed to investigate the piecewise linear relationship between NLR and hearing loss, as well as low-frequency, speech and high-frequency PTA. Threshold effect analysis was then used to determine the inflection point. Results The analysis included 5,004 participants. After adjusting for confounding variables, the prevalence of hearing loss increased by 11%(OR=1.11,95%CI:1.02-1.21)for every one-unit increase in NLR, and this difference was statistically significant. NLR was positively correlated with low-frequency, speech, and high-frequency PTA(β=0.78 dB, 0.83 dB, 1.00 dB), and these differences were statistically significant. Smooth curve fitting and threshold effect analysis revealed a piecewise linear relationship between NLR and low-frequency and speech PTA, with an inflection point at 4.19. When NLR<4.19, NLR was positively correlated with low- frequency and speech PTA(β=1.15 dB, 1.16 dB), and the difference was statistically significant. When NLR ≥ 4.19, however, the difference was not statistically significant. Conclusion An increased NLR is associated with an increased prevalence of hearing loss and a higher hearing threshold in adults. This suggests that the inflammatory response may play an important role in the pathological process of hearing loss. As a potential biomarker for assessing risk, the NLR is exploratory and worthy of further verification in clinical studies.

Key words: Neutrophil lymphocyte ratio, Hearing loss, NHANES, Cross-sectional study

CLC Number:

R764.5

WANG Kaijian, WANG Wei, CHEN Xuesheng, FAN Chunsun, HE Yingying, HUANG Dongling, QIAN Cunhui, DING Shujun. Correlation between neutrophil-to-lymphocyte ratio with hearing loss and audiometric thresholds in adults: a cross-sectional study based on NHANES[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(2): 18-28.

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Correlation between neutrophil-to-lymphocyte ratio with hearing loss and audiometric thresholds in adults: a cross-sectional study based on NHANES

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