Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (3): 124-128.doi: 10.6040/j.issn.1673-3770.1.2019.026

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Detection and clinical application of nasal nitric oxide

Zhiwen CHEN,Lei CHENG()   

  1. Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Received:2019-04-25 Revised:2019-05-05 Online:2019-05-20 Published:2019-08-07
  • Contact: Lei CHENG E-mail:chenglei@jsph.org.cn

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Abstract:

Nitric oxide (NO) is synthesized from arginine by the enzyme family NO synthases. NO is an endogenous modulator of airway function. NO from the nose can constitute a nasal defensive barrier, and keep the sinuses relatively sterile. The most commonly clinical detection of nasal nitricc oxide (nNO) is to directly collect NO with a nasal plug probe placed in the anterior nostril. nNO has been used for the screening diagnosis of cystic fibrosis and primary ciliary dyskinesia. However, nNO is related to many influences such as the plugged extent of the sinus. Dynamic monitoring nNO before and after treatment, and combination with frictional exhaled nitric oxide (FeNO）examination to early detect eosinophilic inflmmation in the upper and lower airways are more clinically valuable.

Key words: Nitric oxide, Nasal nitric oxide, Frictional exhaled nitric oxide, Detection, Clinical application

CLC Number: 

  • R765
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