J Otolaryngol Ophthalmol Shandong Univ ›› 2013, Vol. 27 ›› Issue (6): 48-52.doi: 10.6040/j.issn.1673-3770.0.2013.165

• Articles • Previous Articles     Next Articles

Impact of persistent allergic rhinitis of different degrees on the lower airway

ZHANG Kai1, WANG Qiu-ping1, WU Kun-min1, WANG Zhi-yi1, ZHANG Yong1, JI Jun-feng1, CHENG You1, XIE Yan-qing2, ZHONG Nan-shan2   

  1. 1. Department of Otolaryngology and Head & Neck Surgery, School of Medicine, Nanjing University/Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002, China; 2. Guangzhou Institute of Respiratory Diseases, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China
  • Received:2013-06-05 Published:2013-12-16

Abstract:

Objective    To determine the characters and difference of the impact of persistent allergic rhinitis of different degrees on the lower airway. Methods    All patients enrolled in this study were categorized into three groups, the mild group(165 subjects), the moderate/severe group(101 subjects), and the normal control group(136 healthy subjects). Induced sputum differential cytology tests, measurements of exhaled nitric oxide concentration and methacholine bronchial provocation tests were performed. The character and difference in the lower airway among the three groups were compared. Results        ① The measurements of fractional exhaled nitric oxide concentration and the positive rate of fractional exhaled nitric oxide concentration of the moderate/severe group and the mild group both had significant statistical difference with the normal control group(39.07±24.29 vs 25.81±18.68 vs 9.01±10.01, P<0.01; 66.19% vs 33.33% vs 8.82%, P<0.01) ; ② Proportion and positive rate of eosinophils in induced sputum of the two rhinitis groups had no significantly statistical difference with each other(5.51±9.11% vs 4.02±7.10%; 40.59% vs 35.57%, P>0.05), but they both had significantly statistical difference with the normal control group(5.51±9.11% vs  0.48±1.28%, 4.02±7.10% vs 0.48±1.28%; 40.59% vs 1.47%, 35.57% vs 1.47%, P<0.01); ③ Positive rate of bronchial provocation test of the moderate/severe group had significantly statistical difference with the mild group and the normal control group(14.85% vs 4.24%,14.85% vs 1.23%, P<0.01), but the mild group had no significantly statistical difference with the normal control group(4.24% vs 1.23%, P>0.05). Conclusion    ① The disparity of the lower airway inflammation consists in perennial allergic rhinitis of different degrees; ② Our research demonstrates that the moderate/severe perennial allergic rhinitis exhibits superior lower airway abnormality, indicating that such patients have high-risk of suffering from asthma, in view of this condition, they should be paid sufficient attention to by otorhinolaryngologists and respiratory physicians.

Key words: Bronchial hyperresponsiveness, Fractional exhaled nitric oxide, Airway inflammation, Perennial allergic rhinitis, Induced sputum

CLC Number: 

  • R765.21
[1] WAN Wenjin, WANG Wen, CHENG Lei. A meta-analysis of subcutaneous immunotherapy and sublingual immunotherapy in the treatment of dust mite-allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 103-108.
[2] ZHU Xinhua. Clinical applicationof rush immunotherapy for allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 13-17.
[3] GUAN Kai, LI Lisha. Nasal irrigation and its role in the treatment of allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 22-27.
[4] SHI Li, ZHAO Li, ZHANG Hongping. Long-term anti-inflammatory treatment of allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 9-12.
[5] LIU Jing. Treatment of allergic rhinitis using syndrome differentiation based on the concept of “holism” in TCM. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 28-30.
[6] CHENG Lei, QIAN Junjun, TIAN Huiqin. Research progresses on allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 1-3.
[7] XU Yu, TAO Zezhang. Pharmacotherapeutic strategies for allergic rhinitis:Ithe importance of individualization and normalization. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 4-8.
[8] LIU Ying, YE Xiaojing, ZHAO Cunli, JI Qing, HUANG Qian. Preventive treatment for seasonal allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 37-40.
[9] XUE Jianrong, MA Jing, JIANG Xing, HU Zhibang. Clinical analysis of pediatric allergic rhinoconjunctivitis in the southern region of Jiangsu Province. [J]. J Otolaryngol Ophthalmol Shandong Univ, 2017, 31(3): 41-46.
[10] WU Zhongfei, HUAI De, GUI Xiaozhong, ZHAO Xin, ZHOU Wencheng, YUAN Yuan, TIAN Huiqin, LU Meiping, CHENG Lei. Detection and analysis of serum immunoglobulin E levels in healthy volunteers from Jiangsu and Anhui. [J]. J Otolaryngol Ophthalmol Shandong Univ, 2017, 31(3): 50-54.
[11] LI Lizhu, WU Qing, YI Xin, TIAN Li. Research progress on the animal model of allergic rhinitis in traditional Chinese medicine. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 60-63.
[12] SHA Jichao, ZHANG Ce, ZHU Dongdong. Immunocompetence of nasal epithelial cells in allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 55-59.
[13] XIANG Nan, ZHANG Qinxiu. Experience of professor Zhang Qinxiu in the treatment of perennial allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 100-102.
[14] ZHANG Ruxin. Prospect and progress of allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(4): 3-6.
[15] YAN Aihui, HAN Jiali. Clinical features and diagnosis of allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(4): 7-9.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!