JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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A quantitative analysis of NF-kB in laryngeal carcinoma

SUN Yu-cai1，HU Guo-hua2，ZHU Jiang2   

  1. 1. Department of Otolaryngology, Affiliated Hospital of Jining Medical College,Jining 272100;2. Department of Otolaryngology, Affiliated First Hospital of Chongqing Medical University, Chongqing 400016
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-04-24 Published:2007-04-24
  • Contact: SUN Yu-cai

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Abstract: Objective: To explore the significance of the quantitative analysis of NF-kB in laryngeal carcinoma tissues. Methods: The quantitative analysis of the protein content and the DNA binding activity of NF-kB was examined by the Western blot method and electrophoretic mobility shift assay (EMSA) method in 20 cases of laryngeal carcinoma tissues and 10 cases of normal pericarcinoma tissues. Results: The protein content and the DNA binding activity of NF-kB in laryngeal carcinoma tissues were higher than those in pericarcinoma normal tissues（P<0.05）. Conclusion: The NF-kB might play an important role in the occurrence and development of laryngeal carcinoma and offers a new target of laryngeal carcinoma treatment.

Key words: Laryngeal neoplasms, Nuclear transcription factor kappa B, Western blot, Electrophoretic mobility shift assay (EMSA)

CLC Number: 

  • R739.65
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