JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

• Articles • Previous Articles     Next Articles

Expression of TRAIL and Survivin proteins in the carcinogenesis and development of laryngeal carcinoma

WU Kai, MA Mao-qiang， WANG Chun-hai, ZHANG Yong   

  1. Department of Patholgy, Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011, Shandong, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-04-24 Published:2007-04-24
  • Contact: WU Kai

PDF (PC)

1479

Abstract: Objective: To explore the correlation between the expressions of TRAIL and Survivin proteins and the pathologic features of laryngeal epithelial lesions. Methods: Immunohistochemistry was used to determine the expressions of TRAIL and Survivin proteins in normal mucosa and displasia and invasive carcinoma tissues of 48 cases of laryngeal carcinoma. Results: The expression of Survivin protein progressively increased, whereas that of TRAIL protein gradually decreased in a route of normal mucosa and displasia and invasive carcinoma tissues. The expression of TRAIL protein in laryngeal invasive carcinoma was negatively correlated with that of Survivin protein (r=-0.510, P<0.01). Conclusions: The expressions of TRAIL and Survivin proteins are significantly related to the genesis and progression of laryngeal carcinoma.

Key words: Laryngeal neoplasms, Pathology, Immunohistochemistry, Tumor necrosis factor related apoptosis inducing ligand, Survivin

CLC Number: 

  • R739.65
[1] BAI Yong, YIN Yingchun, HAN Xuefeng, YIN Zhaofu, LI Xuezhong. Clinical analysis of low-grade myofibroblastic sarcoma of the head and neck [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 58-61.
[2] LI Hao, LI Yanzhong, WANG Yan. Hypoxia inducible factor-1 alpha and vascular endothelial growth factor expression in the soft palate of [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(2): 43-47.
[3] ZHANG Menglu, LI Yongtuan.. Expression of chemokine ligand 27 in secondary middle ear cholesteatoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(6): 46-48.
[4] FU Yugui, WANG Hailan, SUN Dechong, YANG Peizhen, CHEN Yanlin, CHEN Zhipeng. Total laryngectomy with partial preservation of the cricoid cartilage ring. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 73-75.
[5] AN Yongming, MU Wenli, TIAN Yanxun, LI Wei, WU Yanqiao. The significance of Maspin and Ets1 in laryngeal squamous carcinoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 91-94.
[6] ZENG Wanting, CHEN Yanren, TAN Yun, LI Te, ZHANG Min, GUAN Liqian, CHEN Jichuan, JI Changyou, LIU Rongrong. Histopathologic analysis of 81 cases of parotid malignant tumor. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(6): 104-106.
[7] LÜ Dan, YANG Hui, YIN Rui, GU Deying, ZHENG Yitao. The middle ear cerumen gland tumor of three cases and review of the literature [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(6): 8-12.
[8] LI Fu, ZHAO Shuyou. Expression of tumor suppressor in lung cancer 1 in laryngeal squamous cell carcinoma and its significance [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(6): 36-38.
[9] YAN Yu, ZHU Jiang. Advances in the diagnosis of early laryngeal carcinoma and precancerous laryngeal lesions. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(4): 80-85.
[10] YU Hai-yang, ZHANG Zeng, DIAO Xiu-li, WANG Wei-guo. A case of ceruminoma in right external auditory canal [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(5): 101-102.
[11] LIU Shu-jun, DAI Xiu-yu, LIU Shao-yi, WANG Wen-ting, LI Yuan-bin. Expression of survivin in animal model of posterior capsule opacification [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(4): 81-84.
[12] WEI Xi-jian1, YIN Rui-lan2, GUO Xing3. Expression of a proliferation-inducing ligand in laryngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(1): 14-16.
[13] XU Zhen1, YU Hai-ling1, LIU Bing2. Expression and significance of aquaporin-4 in nasal polyps [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(1): 48-50.
[14] CHEN Zhi-xi1, LIU Yang-yun2, ZHOU Wen-fang1, ZHANG Jin-ping1, LUO Xu-yong1, YE Xue-meng1, XIONG Qi-bin1, LIU Huo-wang3. Diagnosis, treatment and biocharacteristics of myoepithelial Carcinoma in head and neck [J]. J Otolaryngol Ophthalmol Shandong Univ, 2013, 27(6): 22-25.
[15] L Feng， LI Yong-tuan. Expression and significance of CyclinD1 in middle ear cholesteatoma [J]. J Otolaryngol Ophthalmol Shandong Univ, 2013, 27(2): 13-15.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd