JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Relationship between Eotaxin-1 expression and eosinophili infiltration in nasal polyps with fungal ball rhino-sinusitis

HONG Juan1, HUANG Jian-min2,LIN Guo-jing2   

  1. 1. Department of Otolaryngology, Affiliated First Hospital of Wenzhou Medical College,Wenzhou 325000, Zhejiang, China;2. Affiliated Union Hospital, Fujian Medical University, Fuzhou 350001, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2008-04-24 Published:2008-04-24
  • Contact: HONG Juan

Abstract: To explore the histopathological characteristics of nasal polyps with fungal ball rhino-sinusitis, and to determine the expression of Eotaxin-1 and its relationship with eosinophili infiltration. MethodsTwenty cases of nasal polyps with fungal ball rhino-sinusitis and fifteen cases of normal inferior turbinate mucosa were enrolled in this study. Immunohistochemical staining for Eotaxin-1 protein and HE staining for eosinophils were performed in two groups. Results① Lost epithelium and squamous metaplasia were usually observed in nasal polyps with fungal ball rhino-sinusitis. In the stroma there were a lot of lymphocyte, eosinophil and phagocyte infiltration, sometimes there were a lot of fibrocytes, also there were briskly capillary hyperplasia, but there were no fungi in the nasal mucous. ② Eotaxin-1 constitutively expressed in the inferior turbinate mucosa and highly expressed in nasal polyps with fungal ball rhino-sinusitis (P<0.05). Eotaxin-1 immuno-reactivity was mostly determined in the epithelium and vascular endothelial cells. Some eosinophils and phagocytes in the stroma were also identified as Eotaxin-1 positive cells; ③ Tissue eosinophilia in nasal polyps with fungal ball rhino-sinusitis was associated with the expression of Eotaxin-1 protein (P<0.05). ConclusionFungi are probably responsible for tissue eosinophilia by increasing the Eotaxin-1 protein in nasal polyps with fungal ball rhino-sinusitis. Eotaxin-1 antagonist may contribute to the treatment of nasal polyps with fungal ball rhino-sinusitis.

Key words: Nasal polyp, Eosinophil, Sinusitis, Eotaxin-1, Fungi

CLC Number: 

  • R765.21
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