JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Correlation between aquaporin-5 expression and curative results of nasal polyp operations

CAO Ying-chun1,　SHI Xue-yan1,　LI Jian-dong1,　WANG Zong-feng1,　LI Xin-gong2   

  1. 1. Department of Otorhinolaryngology; 2. Department of Pathology, Dongying People′s Hospital, Dongying 257091, Shandong, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2008-10-16 Published:2008-10-16
  • Contact: CAO Ying-chun

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Abstract: To observe the distribution and expression of aquaporin-5(AQP5) in recurrent nasal polyps and cured ones and to explore the relationship between AQP5 in nasal polyps and the curative results of nasal polyp operations. MethodsEndoscopic sinus surgery was performed on 63 patients with nasal polyps who were followed up for 6 months. After the operations, nasal padding materials were removed at 48 hours, hormones were used for 1 to 2 months, saline was used for flushing the nostrils once daily for 1 to 3 months and the nasal cavity was cleaned up under nasal endoscopy once a week for 1 month, and then once every two weeks for 3 to 6months. AQP5 expression was determined by immunohistochemistry in the recurrent nasal polyp group and the cured group. ResultsThe expression of AQP-5 positive cells was statistically significantly decreased in the recurrent nasal polyp group compared with the cured group(P＜0.05). ConclusionsOverexpression of AQP5 may influence the recurrence of nasal polyps and it might be used as an index for prognosis of nasal polyps after the operations.

Key words: Endoscopy, Aquaporins, Nsal polyps, Immunohistochemistry

CLC Number: 

  • R765.24
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