JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (6): 46-48.doi: 10.6040/j.issn.1673-3770.0.2017.290

Previous Articles     Next Articles

Expression of chemokine ligand 27 in secondary middle ear cholesteatoma.

ZHANG Menglu, LI Yongtuan.   

  1. Department of Otolaryngology &Head and Neck Surgery, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao 266000, Shandong, China
  • Received:2017-07-03 Online:2017-12-16 Published:2017-12-16

PDF (PC)

205

Abstract: Objective To explore the pathological expression of chemokine ligand 27(CCL27)and discuss its possible clinical significance in secondary middle ear cholesteatoma. Methods The SP immunohistochemical staining technique was applied to detect the expression of CCL27 in 30 samples of secondary middle ear cholesteatoma tissue and 30 samples of normal auricle skin. Results Of the secondary middle ear cholesteatoma tissue samples, 6.7% were positive for CCL27 expression, whereas 33.3% of the normal auricle skin samples were positive for CCL27 expression. CCL27 was expressed less commonly in the former, and there was a significant difference in the rate of expression between the two groups(P=0.021). Conclusion The lower expression of CCL27 may be correlated with the hyperproliferative nature of the secondary middle ear cholesteatoma epithelium. CCL27 may play a significant role in the development of secondary middle ear cholesteatoma.

Key words: Immunohistochemistry, CCL27, Secondary middle ear cholesteatoma

CLC Number: 

  • R764.21
[1] Habesoglu TE, Balak N, Habesoglu M, et al. Intracranial cholesteatoma: a case report and review[J]. J Emerg Med, 2007, 32(4): 375-379.
[2] Olszewska E, Wagner M, Bernal-Sprekelsen M, et al. Etiopathogenesis of cholesteatoma[J]. Eur Arch Otorhinolaryngol, 2004, 261(1): 6-24.
[3] Quaranta N, Cassano M, Quaranta A. Facial paralysis associated with cholesteatoma: a review of 13 cases[J]. Otol Neurotol, 2007, 28(3): 405-407.
[4] Migirov L, Bendet E, Kronenberg J. Cholesteatoma invasion into the internal auditory canal[J]. Eur Arch Otorhinolaryngol, 2009, 266(5): 657-662.
[5] Morales J, Homey B, Vicari AP, et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells[J]. Proc Natl Acad Sci U S A, 1999, 96(25): 14470-14475.
[6] Riis JL, Johansen C, Vestergaard C, et al. CCL27 expression is regulated by both p38 MAPK and IKKbeta signalling pathways[J]. Cytokine, 2011, 56(3): 699-707.
[7] Homey B, Alenius H, Muller A, et al. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation[J]. Nat Med, 2002, 8(2): 157-165.
[8] Inokuma D, Abe R, Fujita Y, et al. CTACK/CCL27 accelerates skin regeneration via accumulation of bone marrow-derived keratinocytes[J]. Stem Cells, 2006, 24(12): 2810-2816.
[9] Pivarcsi A, Muller A, Hippe A, et al. Tumor immune escape by the loss of homeostatic chemokine expression[J]. Proc Natl Acad Sci U S A, 2007, 104(48): 19055-19060.
[1] LI Hao, LI Yanzhong, WANG Yan. Hypoxia inducible factor-1 alpha and vascular endothelial growth factor expression in the soft palate of [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(2): 43-47.
[2] AN Yongming, MU Wenli, TIAN Yanxun, LI Wei, WU Yanqiao. The significance of Maspin and Ets1 in laryngeal squamous carcinoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 91-94.
[3] LI Fu, ZHAO Shuyou. Expression of tumor suppressor in lung cancer 1 in laryngeal squamous cell carcinoma and its significance [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(6): 36-38.
[4] WEI Xi-jian1, YIN Rui-lan2, GUO Xing3. Expression of a proliferation-inducing ligand in laryngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(1): 14-16.
[5] XU Zhen1, YU Hai-ling1, LIU Bing2. Expression and significance of aquaporin-4 in nasal polyps [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(1): 48-50.
[6] CHEN Zhi-xi1, LIU Yang-yun2, ZHOU Wen-fang1, ZHANG Jin-ping1, LUO Xu-yong1, YE Xue-meng1, XIONG Qi-bin1, LIU Huo-wang3. Diagnosis, treatment and biocharacteristics of myoepithelial Carcinoma in head and neck [J]. J Otolaryngol Ophthalmol Shandong Univ, 2013, 27(6): 22-25.
[7] L Feng， LI Yong-tuan. Expression and significance of CyclinD1 in middle ear cholesteatoma [J]. J Otolaryngol Ophthalmol Shandong Univ, 2013, 27(2): 13-15.
[8] QIAN Ye, LEI Da-peng, JIN Tong, LIU Da-yu, XU Feng-lei, PAN Xin-liang. Expression of Slit2 and its correlation with lymphatic vessel density in hypopharyngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(5): 12-15.
[9] SHEN Bin, DONG Pin, YING Xin-jiang, GAO Shang, LI Da-wei. Expressions and implication of ABCG2 and NF-κB p65 in hypopharyngeal cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(4): 17-20.
[10] BAI Yong1， LI Na2， ZHAO Shen-lin1， ZHANG Min1. Effect of Azithromycin on NF-kBp65 and IL-8 in nasal mucosa of chronic sinusitis after endoscopic sinus surgery [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(3): 40-44.
[11] WU Gui-qing1, TIAN Jun2, SUN Jing1, CHEN Qi1. 1. Expression and significance of Tiam1 and MTA1in human laryngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(1): 41-43.
[12] CAI Zhi， ZHENG Shi-xin， GAO Chong-yang. Follicular Dendritic Cell Sarcoma of Tonsil: a case report and review [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(1): 55-57.
[13] ZOU Ji-dong, XU Wei, L Zheng-hua, CAO Hong-yuan. Correlation between maspin and p53 proteins in laryngeal carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(6): 16-18.
[14] LI Zhi-zhang1, LI Qin2, GENG Yu-yan3， SHAO Yang1. Effect and significance of the TGF-β1/Smad4 signaling system in laryngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(2): 16-.
[15] . Expression of the KAI1 gene in laryngeal carcinoma and metastasis lymph nodes [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(2): 11-13.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd