JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2011, Vol. 25 ›› Issue (2): 16-.

• Articles • Previous Articles     Next Articles

Effect and significance of the TGF-β1/Smad4 signaling system in laryngeal squamous cell carcinoma

LI Zhi-zhang1, LI Qin2, GENG Yu-yan3, SHAO Yang1   

  1. 1. Taishan Medical College Graduate, Taian 271000, Shandong, China;
    2. Department of Otolaryngology & Head and Neck Surgery, The People′s Hospital of Linyi, Linyi 276000, Shandong, China;
    3. Department of Dermatology, The People′s Hospital of Mazhan, Yishui 276400, Shandong, China
  • Received:2010-12-05 Revised:2011-01-19 Online:2011-04-16 Published:2011-04-16

Abstract:

Objective     To explore the effect and significance of the TGF-β1 signaling system in laryngeal squamous cell carcinoma(LSCC). Methods    The immunohistochemical method was used to detect expression of TGF-β1, TβRII, and Smad4 in 44 cases of LSCC and 10 cases of normal laryngeal mucosa. Correlation between the results and LSCC progress and metastasis was analyzed. Results     The expression rate of TGF-β1 in the LSCC group was 68.2%, which was significantly different from the normal laryngeal mucosa group(30.0%, P<0.05), and the expression of TGF-β1 was associated with clinical stages and lymph node metastasis(P<0.05). The positive expression rate of TβRII and Smad-4 was 40.9%, 34.1% in the LSCC group  and  80.0%, 80.0% in the normal laryngeal mucosa group(P<0.05). There was a negative correlation between TβRII and clinical stages (P<0.05), but no correlation between TβRII and lymph node metastasis(P>0.05). There was a negative correlation between Smad4 and the clinical index(P<0.05),  including pathological differentiation, clinical stage and lymph node metastasis.  Conclusion    There is a significant correlation between the abnormal TGFβ1/Smad4 signaling system and LSCC progress. Low expression of Smad4 may accelerate lymph node metastasis of LSCC.

Key words: Laryngeal neoplasms; Carcinoma, squamous cell; Transforming growth factor -β1; Transforming growth factor-βreceptorII; Smad4;Immunohistochemistry

CLC Number: 

  • R739.65
[1] JIA Chuan-liang, WANG Li, CHEN Xiu-mei, SONG Xi-cheng. null [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(6): 83-83.
[2] LU Guo-wei, WANG Lin, SUN Yan, LI Wei, HUA Hui, GE Rui-feng. Detection of different subtypes of HPV DNA in 57 cases of laryngeal carcinoma in easter of the shandong province [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(6): 16-19.
[3] SUN Rui-jie, XU Feng-lei, LIU Da-yu, LEI Da-peng, PAN Xin-liang. Effect of CO2 laser surgery combined with interferon on recurrent juvenile laryngeal papillomatosis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(6): 23-25.
[4] CHEN Yong, XIE Xiu-fang, LIU Fang, JIANG Yi, LI Rui-yu. Treatment of laryngeal papilloma with bone marrow mesenchymal stem cells transfected with the IFN-γ gene [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(3): 24-27.
[5] ZHANG Shu-jia1, LI Pei-hua2, JIA Wen-bo1, XU Heng-guang1, BAO Feng-xiang1, LI Li1. 1. Expression and clinical significance of programmed cell death 5 (PDCD5) in laryngeal squamous cell carcinoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(2): 23-26.
[6] WU Gui-qing1, TIAN Jun2, SUN Jing1, CHEN Qi1. 1. Expression and significance of Tiam1 and MTA1in human laryngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(1): 41-43.
[7] LI Da-wei, DONG Pin, GAO Shang. Significance of apoptotic and proliferative indices and  P-glycoprotein expression in laryngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(4): 8-12.
[8] WU Hongliang1, GAO Yanyong1, YU Junxiong2, TAO Zanying3, LIU Qianghe1, HE Xiaosong1, GENG Wanping1. Effect of patient-controlled intravenous analgesia for endoscopic sinus surgery on plasma IL-6 and IL-10 [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(4): 44-47.
[9] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(4): 73-74.
[10] XU Hong-ming, DONG Pin, SUN Zhen-feng, WANG Guo-liang, WANG Fei. Preliminary study of animal models for laryngeal surgery [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(3): 15-.
[11] YI Hai-jin1, ZHANG Bao-quan2, WANG Chun-hong1, GUO Hong1, NI Fu-qiang1. Clinical analysis and treatment of recurrent laryngeal cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(3): 18-21.
[12] JIANG Shao-hong, SONG Xi-cheng, ZHANG Qing-quan, ZHU Yu-hong, SUN Yan, ZHANG Hua, WANG Qiang. Therapeutic effect of endoscopic sinus surgery on cyst of the  nasal sinus with an image navigation system [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(2): 60-62.
[13] SUN Yan, SONG Xi-cheng, ZHANG Qing-quan, ZHANG Hua, LIU Zhong-lu, WANG Qiang, JIANG Shao-hong, LIU Fei-fei. Application of image navigation in maxillary sinus surgery  for benign pathological bone lesions [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(2): 63-.
[14] ZENG Zhi-mei1, LIANG Yong-hui2, YANG Yi-fang2, DOU Xiao-qing2,LUO Bi-qiang2, ZHANG Li-wei2, CHEN Xian-ming2. Expression of macrophage migration inhibitory factor  in human carcinomas of the hypopharynx [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(1): 17-19.
[15] GAO Shang, DONG Pin, LI Da-Wei, SHEN Bin. Potential mechanism of Platelet derived growth factor-BB to  promote the proliferation and invasion of Hep2 cells [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(1): 20-23.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!