Abstract:

Objective To evaluate the clinical effect of CO2 laser microsurgery through suspension laryngoscope combined with human leukocyte interferon on children with recurrent laryngeal papilloma. Methods Clinical data of 61 recurrent laryngeal papilloma patients, treated in E.N.T. Department of Qilu Hospital from 2004 to 2009, were reviewed. All the patients underwent CO2 laser microsurgery through suspension laryngoscope. According to the postoperative medication, the patients were further divided into group A (no interferon) or group B (with interferon). The number of anatomical sites involved by papilloma were counted before and after the treatment. Results Before the operation, the number of anatomical sites involved by papilloma before operationin both groups were 1 to 8 with the average of 3.45±1.86 in group A and 3.53±1.67 in group B. After the treatment, the number of sites turned into 1 to 4 in group A and 1 to 3 in group B with the average value of 2.09±0.87 and 3.53±1.67, respectively(P＜0.05). Conclusion CO2 laser microsurgery, with or without interferon treatment, can delay the recurrence of laryngeal papilloma. However, The number of sites involved by papilloma decreases significantly in the microsurgery combined with interferon treatment.

Key words: Papilloma; Laryngoscopy; Laser; Interferon