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    16 December 2012 Volume 26 Issue 6
      
    Articles
    Obstructive sleep apnea hypopena syndrome caused by laryngeal diseases
    LI Shu-hua, SHI Hong-jin, DONG Wei-dong, WU Da-hai
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  1-3. 
    Abstract ( 1136 )   Save
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    Objective To explore the etiology, manifestation and therapy of obstructive sleep apnea hypopnea syndrome caused by laryngeal diseases(OSAHSLD). Methods 13 patients with OSAHSLD were included in the study. The etiology, manifestation and therapy were reviewed. Results The 13 OSAHSLD patients, diagnosed by plysomnography, obtained good curative effect after the laryngeal lesions were removed. The laryngeal diseases consisted of bilateral vocal cords paralysis(6 cases), laryngeal papillary epithelioma(1 case), epiglottis neurilemmoma(1 case), huge epiglottis cyst(3 cases), and epiglottis softening(2 cases). The body mass indexes were normal in all the patients, and moderate dyspnea was noted in the patients with bilateral paralysis of vocal cords. Conclusion The OSAHS can be induced by laryngeal disease, in which tumor/cyst of epiglottis and paralysis of bilateral vocal cords are common etiology. OSAHSLD can be cured if the primary laryngeal diseases are removed.

    Correlation of neck circumference with sleepingrespiratory parameters and dimensions of upper airway in obstructive sleep apnea hypopnea syndrome patients
    YANG Ge-fei, LI Shu-hua, WU Da-hai
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  4-7. 
    Abstract ( 1092 )   PDF (1250KB) ( 1052 )   Save
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    Objective To analyze the correlation of neck circumference (NC) with sleepingrespiratory parameters and dimensions of upper airway in the patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods 61 OSAHS patients diagnosed by polysomnogaphy (PSG) were included in this study. With CT scanning, the velopharyngeal and glossopharyngeal crosssectional area, dimensions of upper airway and the area ratio of pharynx/neck were measured. NC, body mass index (BMI), height and weight were collected. The correlation between NC and the other parameters were analyzed. Results In 61 OSAHS patients, NC was positively correlated with BMI (r=0.623, P<0.01), and positively correlated with T90 and ODI, respectively (r=0.284, P<0.05; r=0.260, P<0.05). NC was negatively correlated with LSaO2 (r=-0.317, P<0.05), as well as two area ratios of pharynx/neck (r=-0.258, P<0.05; r=-0.276, P<0.05). Finally, NC was positively correlated with the front diameter of velopharyngeal region and the back diameter of glossopharygeal region (r=0.293, P<0.05; r=0.290, P<0.05). Conclusion The increasing NC can scale down the crosssectional area of upper airway and aggravate airway obstruction, hypertrophy of soft palate, and hyoxemia. NC is a good predictor for the development of OSAHS.

    Relationship between Friedman OSA staging and ZPPP plus GAHM
    SUN Xiao-qiang1, YI Hong-liang2, CAO Zhen-yu2, ZHANG Yu-jun2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  8-9. 
    Abstract ( 1837 )   PDF (1023KB) ( 2748 )   Save
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    Objective To explore the relationship between Friedman OSA staging and genioglossus advancement and hyoid suspension(GAHM) plus Z-palatopharyngoplasty(ZPPP). Methods 26 patients with severe OSAHS (AHI>40)were performed GAHM plus ZPPP. The obstructive sites were identified in both oropharynx and hypopharynx. The follow up lasted at least 6 months postoperatively. The Chi square test was used to compare the preoperative and postoperative results. Results Satistying clinic results for the patients with Friedman OSA stages Ⅱ were 100%, while the overall success rate of Friedman OSA stages Ⅲ was 22.2%. Conclusion ZPPP plus GAHM is an effective method for patients with Friedman OSA stages Ⅱ.

    Ventilation expansion techniques in surgical treatment of obstructive sleep apnea hypopnea syndrome
    TAN Jie, YANG Jian-guo, WANG De-sheng, LIU Jian-zhi, HU Xiao-hua, HUANG Jian-min
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  10-12. 
    Abstract ( 1290 )   PDF (989KB) ( 1427 )   Save
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    Objective To explore the significance of nasal cavity expansion in the treatment of obstructive sleep apnea hypopnea syndrome (OSAHS). Methods Based on the theory of nasal cavity ventilation expansion techniques, fifty OSAHS patients with nasal structural abnormalities underwent the nasal cavity ventilation expansion surgery. Results Nasal blockage and lethargy were effectively reduced and the lowest oxygen saturation increased after the surgery. However, AHI had a marginally significant difference from that before the operation, it was still high and not dropped to the normal level. Conclusion We can confirm the efficacy of the nasal cavity ventilation expansion techniques in the treatment of OSAHS.

    Application of ropivacaine in uvulopalatopharyngoplasty
    CHEN Xiao-dong1, YANG Hong-fei2, ZHU Li-xin1, YAN Zhi-song1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  13-15. 
    Abstract ( 1032 )   PDF (1348KB) ( 1292 )   Save
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    Objective To evaluate the safety and effectiveness of ropivacaine mesylate in uvulopalatopharyngoplasty (UPPP). Methods Based on the concentration of ropivacaine applied in the operation, 80 UPPP patients were divided randomly into group A (0.15% ropivacaine), B (0.3% ropivacaine), C (0.6% ropivacaine) or D (no ropivacaine but placebo). Each group consisted of 20 cases. Under general anesthesia, 4Ml of corresponding ropivacaine mesylate were injected into the lower part of palatoglossal arch, while upper and middle parts of palatoglossal arch and upper part of palatopharyngeal arch were infiltrated with 2ml ropivacaine, respectively. For the group D, no ropivacaine but normal saline were applied. Postoperative blood oxygen saturation, breathing, blood pressure and electrocardiogram were monitored , as well as visual analogue scale score (VAS), Ramsay sedation score, use of analgesics at 2,4,6,12,24 and 48hours after the operation. Results VAS score of group A was lower than that of group D at 6th hours after the operation(P<0.05); VAS score of Group B and C were lower than that of group D at 48th hours(P<0.05); Ramsay sedation scores of the four groups were not significantly different; The usage of analgesics in group A, B and C all were lower than group D(P<0.05). In three patients in group C and four in group D, swallowing disorder were noted. No difference of sideeffects among the four groups were significant. Conclusion Ropivacaine shows satisfying pain control and safety in uvulopalatopharyngoplasty, esp. 0.3% ropivacaine.

    Detection of different subtypes of HPV DNA in 57 cases of laryngeal carcinoma in easter of the shandong province
    LU Guo-wei, WANG Lin, SUN Yan, LI Wei, HUA Hui, GE Rui-feng
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  16-19. 
    Abstract ( 1108 )   PDF (1068KB) ( 1464 )   Save
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    Objective To investigate the role of human papillomavirus (HPV) in development of laryngeal squamous cell carcinoma by detecting expression of HPV DNA and its different subtypes in easter of the Shandong province. Methods Fifty-seven patients with laryngeal carcinoma treated in our department were enrolled, and, in the same period, eight patients with papilloma of the larynx served as the control group. HPV subtypes were detected in both groups with a DNA chip technology combining polymerase chain reaction (PCR) with DNA reverse point hybrid. Results Only 4(7.02%)were positive in 57 cases of laryngeal carcinoma specimens, and the positive rate was lower than that in laryngeal papilloma(6/8, 75%)(χ2=24.906,P<0.01). Respectively comparing the expression of highrisk HPV16 and low-risk HPV43 subtypes between the both groups, we did not find significant difference (χ2=5.611,0.143,P>0.05); expressions of lowrisk HPV11 and HPV6 in laryngeal papilloma were higher than those in laryngeal carcinoma (χ2= 8.611,14.702,P<0.05). Conclusion The rate of HPV infection is low among laryngeal carcinoma patients in easter of the Shandong province. Low-risk HPV6 and HPV11 may be closely related with the occurrence of laryngeal papilloma.

    Intratumoral FOXP3 expression and tumor stromal FOXP3positive lymphocyte invasion in esophagus cancer of the neck and their association with clinicopathologic parameters
    ZHAO Miao-qing1, XIA Ming2, LIN Xiao-yan1, LIU Ying1, XU Feng-lei2, QIN Ye-jun1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  20-22. 
    Abstract ( 1068 )   PDF (1323KB) ( 1572 )   Save
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    Objective To investigate the expression of FOXP3 in cancer cells and FOXP3positive lymphocyte invasion in the tumor stroma separately, and to evaluate their clinical values in predicting the prognosis of esophagus cancer of the neck. Methods Envision immunohistochemistry and doubleimmunostaining method were used to detect the expression of Foxp3 and FOXP3positive lymphocyte invasion in 42 specimens of esophagus cancer of the neck and 30 specimens adjacent to carcinoma. Results The positive rate of FOXP3 protein in parenchyma was 42.9% (18/42)in esophagus cancer of the neck and 6.67%(2/30)in tissues adjacent to carcinoma(χ2=10.324, P<0.01). The positive rate of FOXP3positive lymphocytes in mesenchyma was 38.1%(16/42)in cancer tissues and 13.33%(4/30)in tissues adjacent to carcinoma(χ2=15.376, P<0.01). In parenchyma of esophagus cancer of the neck, the expression of FOXP3 protein in the patients with lymph nodes metastasis was positively higher than the patients without(P<0.05). And, the expression in stage Ⅲ orⅣ was all positively higher than that in stages Ⅰor Ⅱ(P<0.05). In cancer’s mesenchyma, the expression rate of FOXP3positive lymphocytes in the patients with lymph node metastasis was positively higher than those without(P<0.05). Conclusion The abnormal expression of FOXP3 protein in cancer’s parenchyma and FOXP3positive lymphocytes infiltration in cancer’s mesenchyma may be closely related to metastasis of esophagus cancer of the neck. It could facilitate the immune escape of esophagus cancer of the neck. FOXP3 may be a potential marker to evaluate metastasis of esophagus cancer of the neck.

    Effect of CO2 laser surgery combined with interferon on recurrent juvenile laryngeal papillomatosis
    SUN Rui-jie, XU Feng-lei, LIU Da-yu, LEI Da-peng, PAN Xin-liang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  23-25. 
    Abstract ( 1066 )   PDF (991KB) ( 1274 )   Save
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    Objective To evaluate the clinical effect of CO2 laser microsurgery through suspension laryngoscope combined with human leukocyte interferon on children with recurrent laryngeal papilloma. Methods Clinical data of 61 recurrent laryngeal papilloma patients, treated in E.N.T. Department of Qilu Hospital from 2004 to 2009, were reviewed. All the patients underwent CO2 laser microsurgery through suspension laryngoscope. According to the postoperative medication, the patients were further divided into group A (no interferon) or group B (with interferon). The number of anatomical sites involved by papilloma were counted before and after the treatment. Results Before the operation, the number of anatomical sites involved by papilloma before operationin both groups were 1 to 8 with the average of 3.45±1.86 in group A and 3.53±1.67 in group B. After the treatment, the number of sites turned into 1 to 4 in group A and 1 to 3 in group B with the average value of 2.09±0.87 and 3.53±1.67, respectively(P<0.05). Conclusion CO2 laser microsurgery, with or without interferon treatment, can delay the recurrence of laryngeal papilloma. However, The number of sites involved by papilloma decreases significantly in the microsurgery combined with interferon treatment.

    Efficacy of pingyangmycin local injection and CO2 laser in the treatment of pharyngeal and laryngeal hemangioma
    WANG Hong-ming1, XUE Wei-shuang2, HE Rui-yan3, JIANG Xue-jun1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  26-27. 
    Abstract ( 1200 )   PDF (1138KB) ( 1531 )   Save
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    Objective To investigate the efficacy of Pingyangmycin local injection and CO2 laser in the treatment of pharyngeal and laryngeal hemangiomas. Methods 25 cases of pharyngeal and laryngeal hemangioma were divided into two groups: Pingyangmycin treatment group (Group A, 16 cases) and CO2 laser treatment group (Group B, 9 cases). Results The cure rate was 81.3% (10/13) in group A and 88.9%(1/9) in group B without serious complication. Conclusion Both Pingyangmycin local injection and CO2 laser surgery are effective therapeutic methods for pharyngeal and laryngeal hemangioma, and individualized treatment could improve the effect.

    Laryngeal schwannoma: A report of 3 cases and literature review
    PENG Li-li, LI Jin-rang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  29-30. 
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    Objective To explore the diagnosis and optimal management of laryngeal Schwannoma. Methods The clinical data of 3 laryngeal Schwannoma cases,from August 2000 to July 2011, were analyzed retrospectively. In addition, the literatures about this disease were reviewed. Results There were 2 female and one male patients, and their ages were 9, 3 and 59 years old, respectively. The lesions were located in the subglottic area, vestibular fold and laryngeal surface of the epiglottis, respectively. The tumors were removed through laryngofissure approach in one case and trans-oral CO2 laser-assisted laryngeal microsurgery in 2 cases. No recurrence was found in 6-month follow up. Conclusion Laryngeal Schwannoma is a rare benign neurogenic tumor of the larynx. Surgical resection is the most effective treatment.

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    ZHENG Li-you
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  31-33. 
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    Primary small-vessel vasculitis firstly diagnosed in ENT: 2 cases report and literature review
    LIU Yu-tao, ZHU Xiao-ning, ZHONG Yan-xia
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  34-35. 
    Abstract ( 1204 )   PDF (1009KB) ( 1055 )   Save
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    Objective To explore the pathogenesis, pathology, clinical manifestation and diagnosis of primary small-vessel vasculitis. Methods We analysed the clinical data of 2 cases with otological symptoms as the first complain and reviewed the literatures of primary smallvessel vasculitis. Results 2 primary small-vessel vasculitis cases presented different manifestations. They were diagnosed by diverse methods and cured with satisfactory outcome. Conclusion They clinical manifestations of primary smallvessel vasculitis are complicated and diverse. It’s easy to be misdiagnosed, especially when the knowledge on otological symptoms caused by vasculitis was poorly understood. The primary symptoms may consist of earache, ear fullness, otorrhea and hearing loss. Early diagnosis and treatment are vital to improve prognosis. Comprehensive analysis is helpful to prevent misdiagnosis of this disease.

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    LI Qi-fang,LI Xu
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  36-37. 
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    Effects of nasal cavity ventilational function by septoplasty with and without partial inferior turbinatomy
    ZHANG Jia-xiong, ZOU Wen-tao, CAI Xiao-jing, QIAN Bei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  38-39. 
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    Objective To study effects of nasal cavity ventilational function by septoplasty with and without partial inferior turbinatomy. Methods 109 patients with nasal septum deviation with or without rhinitis-rhinosinusitis were operated from January 2010 to December 2011. 48 patients were operated with septoplasty without partial inferior turbinatomy from January 2010 to December 2010 (group A), while other 61 patients were operated by septoplasty with partial inferior turbinatomy from January 2011 to December 2011 (group B). Results All 109 patients who accepted endoscopic-assisted correction of the nasal septum deviation with or without partial inferior turbinatomy succeeded in the operations without any severe complications. Nasal airflow was flowing more freely in the group B than in the group A, and visual analogue scale of group A was superior to that of group A. Conclusion Septoplasty with partial inferior turbinatomy is better than septoplasty without partial inferior turbinatomy in improving nasal cavity ventilational function.

    Relationship between anatomic abnormality of the nasal cavity and the nasal sinus and chronic sinusitis
    LIU BO1, ZHANG Zhen-hua2, GAO Ai-min3
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  41-43. 
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    Objective To explore the relationship of anatomic abnormality in the nasal cavity and the nasal sinus with chronic sinusitis. Methods 450 patients were divided into the sinusitis group and the control group ( normal group without sinusitis). Prevalence of different anatomic abnormality such as pneumation and paradoxical curvature of the middle turbinate, agger nasi cell, upper nasal septal deviation, haller’s cell, uncinate process hypertrophy and uncinate process shift were calculated and analyzed by computed tomography. Result The prevalence of anatomic abnormality between the two groups was differently significant (P<0.01). Conclusion Anatomic abnormality in the nasal cavity and the nasal sinus may be related to chronic sinusitis.
    Analysis on characteristics of allergic sensitization in childhood and adult patients with allergic rhinitis
    YAO Ling-qing1, QIU Jian-he1, CHAO Chang-jiang1, MAO Jian-jun1, QIAN Jun-yong2, XUE Jian-rong2, ZHOU Hui-juan2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  44-47. 
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    Objective To investigate positive allergens and sex distribution in childhood and adult patients with allergic rhinitis(AR) in Changzhou City, Jiangsu Province. Methods A total of 4383 cases (aged between 3-75 years) with allergic symptoms and signs underwent skin prick test (SPT)with 16 kinds of standardized allergens. The samples were stratified on childhood and adult groups to analysis the distributive characteristics of allergens responsible for each group. The childhood subjects were further stratified on 3 groups (3-5-year-old, 6-14-year-old, 15-17-year-old) for analysis. Results 1063 cases (78.9%) had the positive reaction in the childhood group, including 717 (67.5%) cases of males and 346 (32.5%) cases of females. 1687 cases (55.6%) had the positive reaction in the adult group, including 715 (42.4%) cases of males and 972 (57.6%) cases of females. Dermatophagoides farinae and Dermatophagodies pteronyssinus had the highest positive ratio (92.9%, 90.8% and 81.0%, 78.9%) in both groups, the 3rd to 5th followed were cat hair (7.2%), cockroach (6.9%) and Humulus L.(5.8%) in the childhood group, cockroach (14.2%), Humulus L.(13.0%), and shrimp (6.4%) in the adult group. There were significantly higher sensitivities to positive ratio of SPT, male and female positive ratio of SPT, positive ratio of Dermatophagoides farinae, Dermatophagodies pteronyssinus, cockroach, Humulus L. and cat hair, positive ratio of single dust mite, male and female positive ratio of single dust mite, and the ratio of class +++, ++++ and ++ in the dust mite position between the childhood group and the adult group (P<0.05). And there were no significantly high sensitivities to the three groups in childhood according to the items above expect positive ratio of SPT between the 6-14-year-old group and the 3-5-year-old group (P<0.05), and the 6-14-year-old and 15-17-year-old groups (P<0.05). Conclusion There are significantly high sensitivity to the main allergens between childhood and adult AR patients in the region. In childhood group, the number of male is higher than that of female in the positive ratio of SPT and the single Dust mite. It suggests that the minors would be more suitable for specific immunotherapy.
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    HAN Hao-lun, WU Wei, WANG Hong-nan, LI Bao-wei, DING Rui-ying
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  48-49. 
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    WANG Cui-qing, LI Bin
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  50-50. 
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    KONG Yong-gang, CHEN Shi-ming, XU Yu, DENG Yu-qin, XU Yong, TAO Ze-zhang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  51-53. 
    Abstract ( 1030 )   PDF (1022KB) ( 1440 )   Save
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    JIN Min1, WANG Chun-ling1, CAI Xiao-lan2, ZHANG Li1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  54-57. 
    Abstract ( 1178 )   PDF (1006KB) ( 1465 )   Save
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    QIN Fei, CAO Bao-gang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  58-58. 
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    KANG Sha-sha, JIN Tong, WEI Dong-min, QIAN Ye, SUN Rui-jie, XIA Ming, LIU Da-yu, XU Feng-lei, LEI Da-peng, PAN Xin-liang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  59-61. 
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    Objective By analyzing the clinical characteristic of foreign body in the trachea and bronchus, to provide reliable information for diagnosis, treatment, and reduce postoperative complications. Methods From January 2001 to December 2011,the clinical data of 1076 cases of suspected foreign body in the trachea and bronchus were reviewed. Among them, 900 cases were confirmed by rigid bronchoscopy under the general anesthesia. The foreign bodies were removed via transoral bronchoscopy in 885 cases, tracheotomy in 10 cases, and thoracotomy in 5 cases. Results There were 817 plant foreign bodies, 24 animal foreign bodies, and 59 metal or plastic foreign bodies. 333 foreign bodies located in the left main bronchus, 397 in the right main bronchus , 77 in the trachea, 16 in the subglottic area. After the operation, there were one pulmonary infection, 1 pneumothorax and mediastinal emphysema, and 3 heart failure cases. 845 patients came within Shandong province, while the other 55 cases didn’t. Conclusion To prevent postoperative complications and guarantee the success of treatment, timely diagnosis and immediate bronchoscopy are crucial for the tracheobronchial foreign body patients.

    Evaluation of MSCT three-dimensional reconstruction in diagnosis of tracheobronchial foreign body
    WANG Bo-tao, SHENG Ying, YAN Jing, HOU Jin, ZHU Kang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  62-63. 
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    Objective To evaluate the value of multi-slice CT(MSCT) three-dimensional reconstruction and Chest X-ray in the differential diagnosis of pediatric tracheobronchial foreign body. Methods 300 cases of suspected trachea-bronchial foreign bodies were reviewed to evaluate the diagnostic value of MSCT three-dimensional reconstruction and Chest X-ray. Results Sensitivity and specificity of MSCT three-dimensional reconstructiong were 100% and 90.3%, with its Youden index at 0.903. However, sensitivity and specificity of normal Chest Xray were 68.9% and 74.2%, with the Youden index at 0.431. Conclusion MSCT three-dimensional reconstruction can improve the accuracy of diagnosis of tracheobronchial foreign body in children.

    Changes of the chamber angle before and after operation for glaucoma secondary to intumescent cataract observed by anterior segment OCT.
    CHEN Kai1, HAN Xu-guang2, LIU Jian2, XU Xiang-hui2, ZHANG Yu-guang2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  65-66. 
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    Objective To observe the changes of chamber angle before and after operation for glaucoma secondary to intumescent cataract. Methods Anterior segment OCT was used to observe angle changes before and after operation in 21 patients (21 eyes) with glaucoma secondary to intumescent cataract who accepted cataract phacoemulsification. Result All indicators of chamber angle were significantly improved and intraocular pressure was reduced after surgery. Conclusion OCT is an objective, accurate, and convenient inspection, and phacoemulsification is an effective treatment method for glaucoma secondary to intumescent cataract.
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    LIU Jie-hui1, LI Jian-ping2, ZHENG Min2, ZHU Wei2, WANG Jian-min1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  67-68. 
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    Clinical observation of combination of traditional Chinese medicine and western medicine for ocular myasthenia gravis
    LIU Lai-fu1, ZHANG Qiang1, YU Li1, WEI De-you1,ZHAO Yan1,BAO Le-wei2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  69-69. 
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    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  70-70. 
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    Current advances of improvement of hypoxia in tumor microenvironment
    XU Ou1,2, LI Xiao-ming1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  71-74. 
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    Although the therapeutic strategy of head and neck squamous cell carcinoma (HNSCC) has been refineed and the life quality of patient has been improved, the overall fiveyear survival rate remains almost unchanged. Both resistance and recurrence are pending problems on therapy of HNSCC. Hypoxic microenvironment in tumor is closely related with the resistance and recurrence. On the other hand, if the effective approaches to improve the hypoxic microenvironment in tumor had been taken, the therapeutic effect would be increased in HNSCC.
    Overview of secretory otitis media treated by combination of traditional Chinese medicine and western medicine
    WANG Lei, YAN Dao-nan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  75-77. 
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    For secretory otitis media (SOM), clinical physicians used to apply the combination of Traditional Chinese Medicine and Western Medicine according to the disease origin of Lung, Liver and Gallbladder, Spleen and Stomach, as well as the pathological nature of stasis. Nasal drip, inflation in the Eustachian tube, tympanum paracentesis, and tube indwelling in tympanic cavity were added to accompany the comprehensive treatment. So, this paper reviewed the general situation of SOM from the perspective of combination of Traditional Chinese Medicine (TCM) and Western Medicine (WM).
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    ZHANG Hua, ZHANG Li-jing, SONG Xi-cheng, ZHANG Qing-quan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  78-82. 
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    JIA Chuan-liang, WANG Li, CHEN Xiu-mei, SONG Xi-cheng
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  83-83. 
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    Ischemic ophthalmopathy induced by disorders of cerebral circulation in 3 cases
    HOU Yan-li, ZHAO Lu, WANG Yan-ling
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(6):  83-88. 
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    ZHANG Xiao-yan, WANG Zhi-qun, ZHANG Yang, SUN Xu-guang
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