J Otolaryngol Ophthalmol Shandong Univ ›› 2013, Vol. 27 ›› Issue (1): 1-7.doi: 10.6040/j.issn.1673-3770.1.2012.015

• Articles •     Next Articles

Sexual behavior and HPV infection in squamous cell carcinoma of the oropharynx

Guojun Li1,2, MD, PhD, Xinliang Pan3, MD, PhD, Dapeng Lei3, MD, PhD, Xingming Chen4, MD, PhD,  Xiaohong Chen5, MD, PHD, Xicheng Song6, MD, PhD   

  1. 1. Department of Head and Neck Surgery; 2. Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, 77030; 3. Department of Otolaryngology & Head and Neck Surgery, Qilu Hospital of Shandong University;  Key Laboratory of Otolaryngology, Ministry of Health, P.R.China,  Jinan 250012,  China; 4. Department of Otolaryngology & Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China; 5. Department of Otolaryngology & Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; 6. Department of Otorhinolaryngology & Head and Neck Surgery, Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, China
  • Received:2012-12-12 Published:2013-02-16
  • Contact: Guojun Li, MD, PhD, Department of Head and Neck Surgery, Unit 1445, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030;Tel: (713) 792-0227

PDF (PC)

848

Abstract:

High risk human papillomavirus (HR HPV) infection is associated with a significant portion of squamous carcinoma of the head and neck, particularly for the oropharynx and for those lacking the other risk factors of tobacco and alcohol.  The link between HR HPV and carcionoma of the oropharynx have been suggested based on the identification of HR HPV in oropharyngeal tumors and association of HR HPV with the risk of oropharyngeal cancer from casecontrol epidemiologic studies. This review highlights the roles of sexual behavior characteristics in patients with oropharyngeal cancer compared with patients with non-oropharyngeal cancers at sites of oral cavity, larynx, and hypopharynx. Determining the behavioral risk factors for head and neck cancer is imperative for future cancer prevention efforts and for understanding the potential role of the HPV vaccine currently available.  This review also expands our understanding of the roles of sexual behavior as a risk factor for oropharyngeal cancer and its role as a marker of HPV exposure and emphasizes that HR HPV is sexually transmitted to the upper aerodigestive tract and that certain sexual behaviors increase the risk for HPV-associated oropharyngeal cancer.

Key words: High risk human papillomavirus, Squamous carcinoma of the head and neck, Sexual behavior

CLC Number: 

  • R739.6
[1] WU Jing, LIU Yehai. Targeted therapy for head and neck squamous cell carcinoma [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 97-102.
[2] SONG Xicheng. Application value of enhanced recovery after surgery in head and neck cancer surgery [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(5): 1-4.
[3] QI Min, LI Hong, WANG Qian, TU Cuifang, YANG Qintai, XU Huiqing. Preliminary application of enhanced recovery after surgery in the perioperative nursing in functional endoscopic sinus surgery [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(5): 13-18.
[4] WEI Dongmin, LI Wenming, QIAN Ye, LIU Dayu, LEI Dapeng, PAN Xinliang. Lateral neck dissection [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 115-115.
[5] LIU Feifei, WANG Xiwen. Giant cell reparative granuloma of temporal bone: a report of one case [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 108-109.
[6] LI Guobin, ZHANG Zhancheng, WANG Xinyan. Up-regulation of miR-200b may inhibit epithelial mesenchymal transition process to prevent the proliferation, migration, and invasion of human laryngeal cancer Hep-2 cells [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 53-57.
[7] YU Qianqian, GUAN Ge, ZHANG Niankai, LI Na, WEN Junfeng, LIU Tingting, LIAN Yuanyuan. Characteristics of respiratory epithelial adenomatoid hamartomas in the nasal olfactory cleft on computed tomography [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 76-81.
[8] LAN Yunying, YANG Yu, LI Hong. A report of 1 case of branchial fissure carcinoma and literature review [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 112-114.
[9] WANG Yuan, ZHOU Han, LIU Xiaojing, ZHANG Liqing, ZHAO Qing, FENG Jian, DONG Weida. Surgical strategies for nasal inverted papilloma and corresponding recurrence rates [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(2): 79-83.
[10] ZHAO Xiaoyan, WU Caiqin, REN Xiaoyong, WANG Zhenghui. A polysaccharide from hedyotis diffusa induces apoptosis and inhibits migration in Hep-2 cells [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(2): 84-87.
[11] LÜ Dan, LI Mingxia, MA Lanzhi, ZHANG Xinyuan, XIAO Hao, CHEN Fei, LIU Jun, LI Zhen. Neurofibromatosis of the head and neck involving the mediastinum: two cases report [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(1): 82-86.
[12] LI Qiaoli, LI Chao, WANG Wei, CAI Yongcong, SUN Ronghao, ZHOU Yuqiu, SHUI Chunyan, HUANG Lu, TU Jing. Primary squamous cell carcinoma of the parotid gland with recurrence and invasion of lateral skull base after radiotherapy and chemotherapy: one case report [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(1): 87-88.
[13] CHEN Hong, CAO Huiling, DOU Xin, GAO Xia. Small cell neuroendocrine carcinoma in the right nasal cavity: a report of one case and a literature review [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(1): 89-92.
[14] ZHANG Caixia, LIU Yangyun, JIANG Wen, LIU Gengxun, CAO Hang, CHEN Qiong, ZHANG Jishuai. Investigation of chemosensitization induced by nitric oxide on nasopharyngeal carcinoma CNE-2 cells. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(5): 72-78.
[15] ZHOU Yibo, GONG Xiaorong, YU Feng. Effects of miR-150 targeted to Nanog on proliferation and invasion of nasopharyngeal carcinoma side population cells. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(5): 79-84.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd