J Otolaryngol Ophthalmol Shandong Univ ›› 2013, Vol. 27 ›› Issue (1): 1-7.doi: 10.6040/j.issn.1673-3770.1.2012.015

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Sexual behavior and HPV infection in squamous cell carcinoma of the oropharynx

Guojun Li1,2, MD, PhD, Xinliang Pan3, MD, PhD, Dapeng Lei3, MD, PhD, Xingming Chen4, MD, PhD,  Xiaohong Chen5, MD, PHD, Xicheng Song6, MD, PhD   

  1. 1. Department of Head and Neck Surgery; 2. Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, 77030; 3. Department of Otolaryngology & Head and Neck Surgery, Qilu Hospital of Shandong University;  Key Laboratory of Otolaryngology, Ministry of Health, P.R.China,  Jinan 250012,  China; 4. Department of Otolaryngology & Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China; 5. Department of Otolaryngology & Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; 6. Department of Otorhinolaryngology & Head and Neck Surgery, Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, China
  • Received:2012-12-12 Published:2013-02-16
  • Contact: Guojun Li, MD, PhD, Department of Head and Neck Surgery, Unit 1445, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030;Tel: (713) 792-0227

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Abstract:

High risk human papillomavirus (HR HPV) infection is associated with a significant portion of squamous carcinoma of the head and neck, particularly for the oropharynx and for those lacking the other risk factors of tobacco and alcohol.  The link between HR HPV and carcionoma of the oropharynx have been suggested based on the identification of HR HPV in oropharyngeal tumors and association of HR HPV with the risk of oropharyngeal cancer from casecontrol epidemiologic studies. This review highlights the roles of sexual behavior characteristics in patients with oropharyngeal cancer compared with patients with non-oropharyngeal cancers at sites of oral cavity, larynx, and hypopharynx. Determining the behavioral risk factors for head and neck cancer is imperative for future cancer prevention efforts and for understanding the potential role of the HPV vaccine currently available.  This review also expands our understanding of the roles of sexual behavior as a risk factor for oropharyngeal cancer and its role as a marker of HPV exposure and emphasizes that HR HPV is sexually transmitted to the upper aerodigestive tract and that certain sexual behaviors increase the risk for HPV-associated oropharyngeal cancer.

Key words: High risk human papillomavirus, Squamous carcinoma of the head and neck, Sexual behavior

CLC Number: 

  • R739.6
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