免疫抑制对非感染性葡萄膜炎的治疗作用及对细胞因子的影响

doi:10.6040/j.issn.1673-3770.0.2015.259

Abstract

Abstract: Objective To explore the effect of immunosuppressive treatment on noninfectious uveitis and to analyse its influence on cytokines. Methods A total of 57 patients with non-infectious uveitis treated in July 2012 to October 2012 were enrolled in this study. Based on different immunosuppressant drug ingredients, they were divided into the experimental group(hormones) and the control group(hormone preparations). Results ① The immunoglobulin Ig-A, G and C3, 4 were significantly higher in the experimental group than in the control group; ③ The greatest impact on cytokines is glucocorticoid, followed by anti-metabolites drugs, alkylating agent, T cell inhibitors, and biological preparations. Conclusion The effect of non-infectious uveitis with immune inhibitors, can effectively improve disease cure rate, of which the effect of glucocorticoid best, therefore, glucocorticoid is a wide range of drugs in the treatment of infective uveitis.

Key words: Immunosuppressive, Glucocorticoid hormone, Cytokines, Noninfectious uveitis

CLC Number:

R773

WANG Zengzhi. Immunosuppressive treatment for non-infectious uveitis and its effect on cytokines[J].JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(6): 64-67.

References

[1] 于晋懿,卢弘.非感染性葡萄膜炎的免疫抑制治疗[J].眼科新进展,2014,34(7):695-700. YU Jinyi, LU Hong. Immunosuppressive therapy for noninfectious uveitis[J]. Rec Adva Ophthalmol, 2014, 34(7):695-700.
[2] 卢弘,余烁.非感染性葡萄膜炎的临床治疗指南及当前实际治疗模式的研究启示[J].中华眼科医学杂志:电子版,2013,3(5):263-267. LU Hong, YU Shuo. The practice guideline of non-infectious uveitis and the revelation of current studies on actual treatment modalities[J]. Chin J Ophthalmol Med Electr Ed, 2013, 3(5):263-267.
[3] Markomichelakis N, Dilieha E, Masselos S, et al. A single infliximab infusion is corticosteroids for acute panuveitis attacks in Behcet's disease: a comparative 4-week study[J]. Rheumatol(Oxford), 2011, 50(3):593-597.
[4] 孙晓茹,毕宏生,郭俊国.青蒿素及其衍生物免疫抑制作用在防治葡萄膜炎中的前景[J].国际眼科杂志,2012,12(6):1078-1080. SUN Xiaoru, BI Hongsheng, GUO Junguo. Prospect of immunosuppression of Artemisinin and its derivatives in uveitis control[J]. Inter Eye Sci, 2012, 12(6):1078-1080.
[5] Matsuda J, Kaburaki T, Kobayashi S, et al. Treatment of recurrent anterior uveitis with infliximab in patient with ankylosing spondylitis [J]. Jpn J Ophthalmol, 2013, 57(1):104-107.
[6] 刘晓菊.自身免疫性葡萄膜炎的免疫疗法研究进展[J].北方药学,2011,8(4):29-30. LIU Xiaoju. Research progress of autoimmune uveitis immunotherapy[J]. Beifang Yaoxue, 2011, 8(4):29-30.
[7] Artornsombudh P, Gevorgyan O, Payal A, et al. Infliximab treatment of patients with birdshot retinochoroidopathy[J]. Ophthalmology, 2013, 120(3):588-592.
[8] 刘雪霞.葡萄膜炎的病因及治疗进展[J].中华眼科医学杂志:电子版,2014,12(1):39-42. LIU Xuexia. Progress in the etiology and treatment of uveitis[J]. Chin J Ophthalmol Med Electr Ed, 2014, 12(1):39-42.
[9] 任亚琳,王增智,王艳丽,等.环孢霉素A对葡萄膜炎中IL-17⁺细胞的作用机制[J].国际眼科杂志,2012,12(6):1054-1055. REN Yalin, WANG Zengzhi, WANG Yanli, et al. Study on the mechanisms of CsA on the IL-17⁺cells in the uveitis patients[J]. Inter Eye Sci, 2012, 12(6):1054-1055.
[10] Van Dartel S A, Fransen J, Kierit W, et al. Difference in the risk of serious infections in patients with rheumatoid arthritis treated with adalimumab, infliximab and etanercept: results from the Dutch Rheumatoid Arthritis monitoring(KREAM) registry[J]. Ann Rheum Dis, 2013, 72(6):895-900.
[11] 温鑫.CD4⁺T细胞与非感染性葡萄膜炎[J].眼科研究,2010,28(6):560-564. WEN Xin. CD4⁺T cell and non-infectious uveitis[J]. Chin Ophthal Res, 2010, 28(6):560-564.
[12] 张莲,毕宏生,郭俊国.抗TNF生物制剂在葡萄膜炎临床治疗中的应用进展[J].眼科新进展,2014,34(12):1187-1189, 1196. ZHANG Lian, BI Hongsheng, GUO Junguo. Application progress of anti-TNF biologic agents for uveitis[J]. Rec Adv Ophthalmol, 2014, 34(12):1187-1189, 1196.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

Comments

Recommended 0

No Suggested Reading articles found!

Immunosuppressive treatment for non-infectious uveitis and its effect on cytokines

PDF (PC)

Abstract

Cite this article

share this article

References

Related Articles 4

Metrics

Comments

Recommended 0

[1]	. The aqueous levels of TNF-α and IP-10 in different kinds of glaucoma and their correlation. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(1): 103-106.
[2]	LIU Ye, SUN Dianshui, YIN Jinjun, XIA Ming, XU Ying, SUN Jianhua. Vestibular function damage mechanisms in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(6): 14-17.
[3]	ZHANG Gehua, LI Wenting. Drug treatment strategy for allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(4): 10-14.
[4]	ZHANG Qing-zhao1, SHIMADA Takashi2, CHENG Lei1. Effect of lysed Enterococcus faecalis FK-23 (LFK) on serum IL-12 in allergic rhinitis mice [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(3): 7-9.