Abstract: Objective To observe the clinical efficacy of anti-refleux therapy in patients with pharyngealforeign body sensation complicated with laryngopharyngeal reflux. Methods A total of 104 patients were selected as study subjects, who had self-rating foreign-body sensation score>3 points, disease course≥1 months, and received continuous anti-reflux treatment for more than 8 weeks due to reflux symptom index(RSI)>13 points and reflux clinical presentation syndrome(RFS)>7 points after scoring. The rates of all reflux syndromes and signs of reflux clinical symptoms were analyzed, and clinical efficacy was evaluated. Results Of the 104 patients, most had reflux symptom hawking behavior(92/104,88.46%), with primary reflux signs being posterior commissurehypertrophy(97/104,93.27%), Erythema/congestion(89/104,85.57%), intra-throat sticky secretions(87/104,83.65%), ventriculuslaryngis obstruction(73/104,70.19%)and so on. After anti-reflux treatment, 61 were effective, with effective rate of 58.65%. Compared with treatment before, there was significant difference in RSI(t=1.975,P<0.05)but no significant difference was observed in RFS (t=1.258,P>0.05)after treatment. Conclusion Anti-reflux treatment is effective to patients with pharyngealforeign body sensation complicated with laryngopharyngeal reflux. As to patients with pharyngealforeign body sensation, laryngopharyngeal reflux should be considered if long-term treatment shows no significant efficacy.

Key words: Laryngopharyngeal reflux, Pharyngeal foreign body sensation, Reflux symptom index, Reflux clinical presentation syndrome