JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (1): 103-106.doi: 10.6040/j.issn.1673-3770.0.2016.201

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The aqueous levels of TNF-α and IP-10 in different kinds of glaucoma and their correlation.

  

  1. Department of Ophthalmology, 1. Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China;2. Xinhua Hospital Chongming Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, 202150, China
  • Received:2016-05-06 Online:2017-02-16 Published:2017-02-16

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Abstract: Objective To investigate the aqueous levels of tumor necrosis factor-α( TNF-α)and interferon-inducible protein-10( IP-10)in glaucoma and the correlation of them. Methods A total of 27 glaucoma patients were recruited and set as the glaucoma group, and another 28 cataract patients with normal intraocular pressure were also selected as the control group. Aqueous fluid of those patients were collected, and the detection of the concentrations of TNF-αand IP-10 was carried out using the cytometric bead array. The outcomes were further analyzed by SPSS 13.0. Results The mean concentrations of TNF-α and IP-10 in eyes with glaucoma were 2.57±0.82 pg/mL and 990.15±766.84 pg/mL respectively, significantly higher than those of eyes with cataract(P=0.003). In subgroup analysis, the concentration of TNF-α in eyes with acute angle closure glaucoma(AACG)was higher than eyes with chronic angle closure glaucoma(CACG); The concentration of IP-10 in the AACG group was higher than that in the CACG and the control group. Besides, the level of IP-10 was positively correlated with the level of TNF-α(r=0.841, P<0.001). Conclusion TNF-α and IP-10 may play important role in the pathogenesis of glaucoma, and different pathogenesis may lead to different level of inflammatory response. The level of IP-10 was positively correlated with TNF-α.

Key words: Glaucoma, Cytokines, Tumor necrosis factor-α, Interferon-inducible protein-10

CLC Number: 

  • R775.3
[1] Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020[J]. Br J Ophthalmol, 2006, 90(3):262-267.
[2] Sommer A. Intraocular pressure and glaucoma[J]. Am J Ophthalmol, 1989, 107(2):186-188.
[3] Tezel G, Wax MB. The immune system and glaucoma[J]. Curr Opin Ophthalmol, 2004, 15(2):80-84.
[4] Li G, Luna C, Liton PB, et al. Sustained stress response after oxidative stress in trabecular meshwork cells[J]. Mol Vis, 2007, 13:2282-2288.
[5] Nakabayashi M. Review of the ischemia hypothesis for ocular hypertension other than congenital glaucoma and closed-angle glaucoma[J]. Ophthalmologica, 2004, 218(5):344-349.
[6] Helbig H, Schlotzer-Schrehardt U, Noske W, et al. Anterior-chamber hypoxia and iris vasculopathy in pseudoexfoliation syndrome[J]. Ger J Ophthalmol, 1994, 3(3):148-153.
[7] Yu AL, Fuchshofer R, Kampik A, et al. Effects of oxidative stress in trabecular meshwork cells are reduced by prostaglandin analogues[J]. Invest Ophthalmol Vis Sci, 2008, 49(11):4872-4880.
[8] Chua J, Vania M, Cheung CM, et al. Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes[J]. Mol Vis, 2012, 18:431-438.
[9] Borkenstein A, Faschinger C, Maier R, et al. Measurement of tumor necrosis factor-alpha, interleukin-6, Fas ligand, interleukin-1α, and interleukin-1β in the aqueous humor of patients with open angle glaucoma using multiplex bead analysis[J]. Mol Vis, 2013, 19:2306-2311.
[10] Yang J, Patil RV, Yu H, et al. T cell subsets and sIL-2R/IL-2 levels in patients with glaucoma[J]. Am J Ophthalmol, 2001, 131(4):421-426.
[11] Hautala N, Glumoff V, Hautala T, et al. IL-2 may possess neuroprotective properties in glaucomatous optic neuropathy[J]. Acta Ophthalmol, 2012, 90(3):e246-247.
[12] Gramlich OW, Beck S, Boehm N, et al. Enhanced insight into the autoimmune component of glaucoma: IgG autoantibody accumulation and pro-inflammatory conditions in human glaucomatous retina[J]. PLoS One, 2013, 8(2):e57557.
[13] Agarwal R, Agarwal P. Glaucomatous neurodegeneration: an eye on tumor necrosis factor-alpha[J]. Indian J Ophthalmol. 2012, 60(4):255-261.
[14] Yang Z, Quigley HA, Pease ME, et al. Changes in gene expression in experimental glaucoma and optic nerve transection: the equilibrium between protective and detrimental mechanisms[J]. Invest Ophthalmol Vis Sci, 2007, 48(12):5539-5548.
[15] Fuchs C, Forster V, Balse E, et al. Retinal-cell-conditioned medium prevents TNF-α-induced apoptosis of purified ganglion cells[J]. Invest Ophthalmol Vis Sci, 2005, 46(8):2983-2991.
[16] Tezel G, Wax MB. Increased production of tumor necrosis factor-alpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells[J]. J Neurosci, 2000, 20(23):8693-8700.
[17] Dong N, Xu B, Chu L, et al. Study of 27 aqueous humor cytokines in type 2 diabetic patients with or without macular edema[J]. PLoS One, 2015, 10(4):e0125329.
[18] Sakurada Y, Nakamura Y, Yoneyama S, et al. Aqueous humor cytokine levels in patients with polypoidal choroidal vasculopathy and neovascular age-related macular degeneration[J]. Ophthalmic Res, 2015, 53(1):2-7.
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