JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (1): 103-106.doi: 10.6040/j.issn.1673-3770.0.2016.201

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The aqueous levels of TNF-α and IP-10 in different kinds of glaucoma and their correlation.

  

  1. Department of Ophthalmology, 1. Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China;2. Xinhua Hospital Chongming Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, 202150, China
  • Received:2016-05-06 Online:2017-02-16 Published:2017-02-16

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Abstract: Objective To investigate the aqueous levels of tumor necrosis factor-α( TNF-α)and interferon-inducible protein-10( IP-10)in glaucoma and the correlation of them. Methods A total of 27 glaucoma patients were recruited and set as the glaucoma group, and another 28 cataract patients with normal intraocular pressure were also selected as the control group. Aqueous fluid of those patients were collected, and the detection of the concentrations of TNF-αand IP-10 was carried out using the cytometric bead array. The outcomes were further analyzed by SPSS 13.0. Results The mean concentrations of TNF-α and IP-10 in eyes with glaucoma were 2.57±0.82 pg/mL and 990.15±766.84 pg/mL respectively, significantly higher than those of eyes with cataract(P=0.003). In subgroup analysis, the concentration of TNF-α in eyes with acute angle closure glaucoma(AACG)was higher than eyes with chronic angle closure glaucoma(CACG); The concentration of IP-10 in the AACG group was higher than that in the CACG and the control group. Besides, the level of IP-10 was positively correlated with the level of TNF-α(r=0.841, P<0.001). Conclusion TNF-α and IP-10 may play important role in the pathogenesis of glaucoma, and different pathogenesis may lead to different level of inflammatory response. The level of IP-10 was positively correlated with TNF-α.

Key words: Glaucoma, Cytokines, Tumor necrosis factor-α, Interferon-inducible protein-10

CLC Number: 

  • R775.3
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