Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (2): 51-56.doi: 10.6040/j.issn.1673-3770.0.2019.073

• Clinical Report • Previous Articles     Next Articles

Clinical analysis of endoscopic surgery for nasopharyngeal carcinoma

Lijuan ZHAO,Yan JIANG*(),Longgang YU,Liang CAI,Min CHEN,Jisheng ZHANG,Zhiyuan LI,Jianbao JU,Na LI   

  1. Department of Otorhinolaryngology Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Shandong Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Shandong Key Laboratory of Digital Medicine and Computer Assisted Surgery, Shandong College Collaborative Innovation Center of Digital Medicine in Clinical Treatment and Nutrition Health, Qingdao 266003, Shandong, China
  • Received:2019-02-20 Online:2019-03-20 Published:2019-03-28
  • Contact: Yan JIANG E-mail:jiangyanoto@163.com

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Abstract: Objective

To explore the clinical efficacy in patients who underwent endoscopic nasopharyngectomy for primary advanced nasopharyngeal carcinoma (NPC).

Methods

Clinical data of 35 patients with NPC admitted to the Department of Otorhinolaryngology Head and Neck Surgery and Nasal Skull Base Surgery of the Affiliated Hospital of Qingdao University from January 2010 to June 2018 were retrospectively reviewed. Twenty-one patients were male, and 14 were female. The median age was 52 years (range, 17-75 years). There were five cases of nasal obstruction, 13 cases of snot with blood, 4 cases of hearing loss and stuffy ear, 5 cases of neck mass, 3 cases of pharyngeal discomfort, and 5 cases of headache and diplopia. The TNM stages were: 5 cases were at stageⅠ, 12 cases were at stage Ⅱ, 12 cases were at stage Ⅲ, and 6 cases were at stage Ⅳ. NX 2 cases, N0 16 cases N1 9 cases, N2 7cases, N3 1 case. No patient was found to have distant metastasis. All patients underwent endoscopic resection of the lesions. Postoperatively, all patients were treated with radiotherapy or chemoradiotherapy. Using SPSS 22.0 software, Kaplan-Meier analysis and Log-rank test were done for the assessment of survival rate.

Results

The pathological types of the 35 patients were as follows: 22 patients had undifferentiated type of non-keratinized carcinoma, 5 patients had non-keratinized differentiated carcinoma, and 8 patients had squamous-cell carcinoma. The follow-up ranged from 3 to 95 months, with relapse observed in 3 cases (10.0%), survival in 31 cases (82.5%), and death in 4 cases (17.5%). The overall 1 year survival rate (SR), 3 year SR, 5 year SR were 95.23%, 95.23%, and 87.91%, respectively.

Conclusion

Patients who undergo endoscopic nasopharyngectomy for NPC have better long-term prognosis.

Key words: Nasopharyngeal neoplasms, Endoscopic surgical procedures, operative, Survival rate

CLC Number: 

  • R739.6

Table 1

Clinical analysis of nasopharyngeal carcinoma"

(n)
影响因素 Ⅰ+Ⅱ期
(n=17)		 Ⅲ+Ⅳ期
(n=18)		 总例数
(n=35)
性别
  男 8 13 21
  女 9 5 14
临床症状
  鼻塞 4 1 5
  涕中带血 8 5 13
  耳闷、听力下降 2 2 4
  颈部肿物 1 4 5
  咽部不适 2 1 3
  头痛、复视 0 5 5
病理类型
  非角化性癌未分化型 12 10 22
  非角化性癌分化型 3 2 5
  鳞状细胞癌 2 6 8
T分期
  Ⅰ+Ⅱ期 17 0 17
  Ⅲ+Ⅳ期 0 18 18
N分级
  NX-0 11 7 18
  N1-2 6 10 16
  N3 0 1 1
生存状态
  存活 16 15 31
  死亡 1 3 4
是否复发
  是 1 2 3
  否 16 16 32

Fig.1

Survival curve of nasopharyngeal carcinoma patients"

Fig.2

Survival curve of nasopharyngeal carcinoma patients with different stages"

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