血小板与淋巴细胞比值对喉癌复发的预测价值

doi:10.6040/j.issn.1673-3770.1.2019.018

Abstract

Abstract: Objective

To evaluate the impact of preoperative platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR) and derived NLR (dNLR) on the prognosis in patients with laryngeal squamous cell carcinoma.

Methods

The clinical data of 473 patients with laryngeal squamous cell carcinoma who underwent primary surgery in the First Affiliated Hospital of Nanjing Medical University were analyzed retrospectively. According to preoperative PLR, NLR and dNLR, the receiver operating characteristic curve (ROC) for diagnosing tumor recurrence was drawn to determine PLR, NLR and dNLR thresholds, and then the patients were divided into the lower groups and the higher groups. Kaplan-Meier analysis and COX risk model were used to analyze the relationship between PLR, NLR, dNLR, and other clinicopathological parameters and recurrence of laryngeal squamous cell carcinoma.

Results

The area under the ROC curve (AUC) of PLR, NLR and dNLR for the diagnosis of tumor recurrence were 0.683, 0.720 and 0.696, respectively. Univariate analysis showed that PLR, NLR, dNLR, tumor classification, TNM stages, pathological differentiation, invasion of thyroid cartilage plate, lymph nodes metastasis, age and coagulation were associated with recurrence in patients with laryngeal squamous cell carcinoma; In COX regression model, a higher PLR, tumor classification and age were identified as independent risk factors for the recurrence of laryngeal squamous cell carcinoma (P<0.001; P=0.033; P=0.030).

Conclusion

Laryngeal squamous cell carcinoma patients with high preoperative dNLR are more likely to relapse. Preoperative PLR is a more valuable prognostic factor than NLR and dNLR for recurrence of laryngeal squamous cell carcinoma. It could be a clinically biomarker for the prognosis of laryngeal squamous cell carcinoma.

Key words: Laryngeal neoplasms, squamous cell, Platelet-lymphocyte ratio, Neutrophil-lymphocyte ratio, Recurrence, Prognosis

CLC Number:

R767

Huijun CHEN,Shenghua SONG,Han ZHOU,Weida DONG,Mingzhe QIAO,Xi CHEN,Jin XU,Ziping LIN,Guangqian XING. Preoperative platelet-lymphocyte ratio is an independent prognostic factor for laryngeal squamous cell carcinoma[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(3): 106-110.

Figures/Tables 6

Fig.1

Fig.2

Fig.3

Fig.4

Table 1

Kaplan-Meier survival analysis: a study of differences between different groups at the end of recurrence of laryngeal squamous cell carcinoma"

变量

平均值（月）

CI（月）

3年生存率（%）

χ 2

dNLR

低

高

93.988

67.571

90.167~97.810

60.724~74.419

78.164

59.864

49.165

<0.001

NLR

低

高

96.185

72.316

92.107~100.262

66.675~77.958

78.039

64.762

43.232

<0.001

PLR

低

高

94.284

72.035

90.176~98.392

66.185~77.885

75.800

66.304

39.036

<0.001

分型

非声门型

声门型

67.656

90.374

59.090~76.222

86.639~94.109

54.286

75.543

28.447

<0.001

分期

I+II

III+IV

90.823

70.084

87.098~94.549

62.052~78.116

77.778

52.672

26.108

<0.001

病理分化

低分化

中+高分化

64.908

87.606

52.291~77.525

83.940~91.272

47.541

74.272

14.723

<0.001

甲状软骨板累及

无

有

86.757

65.196

83.144~90.371

48.735~81.656

72.789

43.750

11.992

0.001

淋巴结转移

无

有

88.984

61.431

85.359~92.609

50.596~72.266

74.631

47.761

28.793

<0.001

年龄

＜60岁

≥60岁

90.846

81.306

85.451~96.242

76.620~85.991

77.325

67.110

6.256

0.012

凝血功能

正常

异常

88.411

74.446

84.610~92.212

65.512~83.379

77.839

51.430

11.685

0.001

Table 1

Table 2

References 14

1	黄选兆, 汪吉宝, 孔维佳. 实用耳鼻咽喉头颈外科学[M]. 北京: 人民卫生出版社，2008:488.
2	FengJF, HuangY, ChenQX. Preoperative platelet lymphocyte ratio (PLR) is superior to neutrophil lymphocyte ratio (NLR) as a predictive factor in patients with esophageal squamous cell carcinoma[J]. World J Surg Oncol, 2014, 12: 58. doi:10.1186/1477-7819-12-58. doi: 10.1186/1477-7819-12-58
3	IshizukaM, NagataH, TakagiK, et al. Combination of platelet count and neutrophil to lymphocyte ratio is a useful predictor of postoperative survival in patients with colorectal cancer[J]. Br J Cancer, 2013, 109(2): 401-407. doi:10.1038/bjc.2013.350. doi: 10.1038/bjc.2013.350
4	RussoA, FranchinaT, RicciardiGRR, et al. Baseline neutrophilia, derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), and outcome in non small cell lung cancer (NSCLC) treated with Nivolumab or Docetaxel[J]. J Cell Physiol, 2018, 233(10): 6337-6343. doi:10.1002/jcp.26609. doi: 10.1002/jcp.26609
5	KangMY, JeongCW, KwakC, et al. Preoperative neutrophil-lymphocyte ratio can significantly predict mortality outcomes in patients with non-muscle invasive bladder cancer undergoing transurethral resection of bladder tumor[J]. Oncotarget, 2017, 8(8): 12891-12901. doi:10. 18632/oncotarget.14179. doi: 10. 18632/oncotarget.14179
6	SabrkhanyS, GriffioenAW, Oude EgbrinkMG. The role of blood platelets in tumor angiogenesis[J]. Biochim Biophys Acta, 2011, 1815(2): 189-196. doi:10.1016/j.bbcan. 2010.12.001. doi: 10.1016/j.bbcan. 2010.12.001
7	MantovaniA, AllavenaP, SicaA, et al. Cancer-related inflammation[J]. Nature, 2008, 454(7203): 436-444. doi:10.1038/nature07205. doi: 10.1038/nature07205
8	GrenaderT, NashS, PlotkinY, et al. Derived neutrophil lymphocyte ratio may predict benefit from cisplatin in the advanced biliary cancer: the ABC-02 and BT-22 studies[J]. Ann Oncol, 2015, 26(9): 1910-1916. doi:10.1093/annonc/mdv253. doi: 10.1093/annonc/mdv253
9	KucharczykJ, SullivanC, LuJ, et al. Prognostic and predictive value of pretreatment derived neutrophil-to-lymphocyte ratio in non-small-cell lung cancer patients treated with an immune checkpoint inhibitor[J]. JCT, 2018, 9(1): 23-34. doi:10.4236/jct.2018.91004. doi: 10.4236/jct.2018.91004
10	DiricanA, KucukzeybekBB, AlacaciogluA, et al. Do the derived neutrophil to lymphocyte ratio and the neutrophil to lymphocyte ratio predict prognosis in breast cancer?[J]. Int J Clin Oncol, 2015, 20(1): 70-81. doi:10.1007/s10147-014-0672-8. doi: 10.1007/s10147-014-0672-8
11	EthierJL, DesautelsD, TempletonA, et al. Prognostic role of neutrophil-to-lymphocyte ratio in breast cancer: a systematic review and meta-analysis[J]. Breast Cancer Res, 2017, 19(1): 2. doi:10.1186/s13058-016-0794-1. doi: 10.1186/s13058-016-0794-1
12	ChenL, ZhangF, ShengXG, et al. Peripheral platelet/lymphocyte ratio predicts lymph node metastasis and acts as a superior prognostic factor for cervical cancer when combined with neutrophil: lymphocyte[J]. Medicine (Baltimore), 2016, 95(32): e4381. doi:10.1097/MD. 000-0000000004381. doi: 10.1097/MD. 000-0000000004381
13	JainS, HarrisJ, WareJ. Platelets: linking hemostasis and cancer[J]. Arterioscler Thromb Vasc Biol, 2010, 30(12): 2362-2367. doi:10.1161/ATVBAHA.110.207514. doi: 10.1161/ATVBAHA.110.207514
14	SuzukiK, AiuraK, UedaM, et al. The influence of platelets on the promotion of invasion by tumor cells and inhibition by antiplatelet agents[J]. Pancreas, 2004, 29(2): 132-140.

Related Articles 15

[1]	MIAO Hongli, ZHANG Yanchun, HAO Linna, TANG Le, HE Yingnan. Clinical features and prognostic analysis of active ocular toxoplasmosis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 82-89.
[2]	PENG Zhonghua, CHEN Zhu, YUAN Luohua, YU Shaolan, MA Yuling. Primary high-grade non-intestinal-type adenocarcinoma of the nasal cavity: a case report and review of the literature [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 95-98.
[3]	LI Zan, LU Qi, SHEN Weidong, HOU Zhaohui, WU Nan. Clinical diagnosis and treatment features of 18 cases of necrotizing otitis externa [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 17-22.
[4]	LIU Yuzhu, CHEN Yao, YUAN Tiejun, LI Chunsen, LI Bo. Larynx fibrosarcoma: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 133-137.
[5]	LIU Nanxian, YANG Zeyin, HAN Lin, ZHANG Aiying, ZHAO Yuliang, XUE Jing, SUN Yijun, SHAO Yongliang. Significance of video-EEG in the diagnosis of recurrent vertigo in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 20-25.
[6]	WANG Wenqing, ZHANG Dan, ZHU Mengdi, WANG Luyang, YANG Peipei, SUN Sisi, ZHANG Qiumin, ZHOU Hui. Changes of clinical and histopathological characteristics in recurrent chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 46-53.
[7]	LI Ting, ZHAO Chong, WU Xian. The relationship between miR-34a expression in nasal mucosa tissue and postoperative recurrence in patients with chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 20-25.
[8]	LI Meichen, CHEN Hailing, LI Yang, MA Dengdian. Mucocele of inferior turbinate: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 91-94.
[9]	YANG Kaiyan, TANG Fengzhu, QIN Qicai, LI Xuxiang, FENG Dayi, NONG Fengjing, YANG Qiuyun. Expression of abnormal spindle-like microcephaly associated protein in nasopharyngeal carcinoma and its clinical significance [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 18-25.
[10]	WANG Kaijian, CHEN Xuesheng, WANG Wei. A meta-analysis of the correlation between platelet-lymphocyte ratio and prognosis of laryngeal squamous cell carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 67-73.
[11]	LIU Nan, PANG Mingjie. Review of factors influencing the prognosis of endoscopic dacryocystorhinostomy [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 149-155.
[12]	WU Bo, HUANG Tiande, YAN Bin, CHEN Yi, TANG Yong. Correlation between the anxiety-depression state and idiopathic tinnitus prognosis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(4): 46-52.
[13]	SUN Yongqiang, SONG Zhongyi, WANG Chunfang, LI Xiao, FU Ying, PAN Xinliang. Prognosis and influencing factors in sudden deafness patients with acoustic stapedius reflex threshold [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 7-14.
[14]	HAN Feiyan, WANG Ying. Clinical analysis of 13 cases of neurilemmomas in the nasal cavity and paranasal sinuses [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 21-25.
[15]	LV Ping, LI Dandan, SONG Wei, HONG Liu. Nasolacrimal duct recanalization under nasal endoscopy for neonatal dacryocystitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 71-74.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

Comments

Recommended 0

No Suggested Reading articles found!

变量	HR	HR（CI）	B	P
分型	0.640	0.424~0.964	-0.447	0.033
PLR	2.011	1.378~2.936	0.699	＜0.001
年龄	1.537	1.043~2.265	0.430	0.030

Preoperative platelet-lymphocyte ratio is an independent prognostic factor for laryngeal squamous cell carcinoma

RichHTML

PDF (PC)

Abstract

Cite this article

share this article

Figures/Tables 6

References 14

Related Articles 15

Metrics

Comments

Recommended 0