Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (4): 131-137.doi: 10.6040/j.issn.1673-3770.0.2018.446

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Effects of continuous positive airway pressure therapy on inflammatory markers in obstructive sleep apnea syndrome: a meta-analysis

CHEN Chun1, DING Jian1, XIE Jin2   

  1. Department of Otolaryngology & Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University, Shanghai 200080, China
  • Online:2019-07-20 Published:2019-07-22

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Abstract: Objective In recent years, the morbidity associated with obstructive sleep apnea syndrome(OSAS)has been increasing. It could be associated with inflammatory reactions and is a risk factor for coronary artery disease(CAD). Current evidence suggests that continuous positive airway pressure(CPAP)changes the levels of inflammatory markers. We analyzed the data from published studies using a systematic meta-analysis. Methods Study eligibility criteria included full-text English studies from PubMed, Embase, and Cochrane libraries, addressing the values of at least one of the inflammatory markers before and after CPAP treatment. We used the definition of OSA as an apnea-hypopnea index(AHI)of ≥5/h and reported values as means with standard deviations. Statistical results showed that the serum C-reactive protein(CRP)levels of OSAS patients before and after CPAP treatment were significantly different(Z= 4.55; P<0.000 01; SMD=0.86; 95%CI=0.49-1.23). There were no significant differences in tumor necrosis factor-α(TNFα)levels before and after CPAP treatment(Z=1.92; P=0.05; SMD=1.08; 95%CI=0.02-2.18). Results A total of 17 studies involving 895 OSA patients were included in the meta-analysis of CRP, and 10 studies involving 290 OSA patients on TNF-α were included. Conclusion CPAP therapy partially suppresses systemic inflammation in OSA patients, and substantial differences are present among the various inflammatory markers. CPAP has been proposed to be linked with the pathogenesis of systemic inflammation to prevent cardiovascular diseases.

Key words: Sleep apnea, Continuous Positive Airway Pressure, Inflammatory markers, C-reactive protein, Tumor necrosis factor-α

CLC Number: 

  • R766.7
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