Abstract: Objective To discuss the effects of continuous out-of-hospital administration on the quality of life in patients with laryngeal cancer. Methods From January 2016 to June 2017, 82 patients with laryngeal cancer were selected from No.2 Hospital of Yibin and divided randomly into control and intervention groups using a stratified randomization method. Patients in the control and intervention groups underwent routine out-of-hospital follow-up and continuous out-of-hospital administration, respectively. Finally, the scores of the self-ranking anxiety scale(SAS), self-ranking depression scale(SDS), adult dispositional hope scale(ADHS), normal health status scale(SF-36), quality-of-life questionnaire for cancer patients(QLQ-C30), and functional assessment of cancer therapy-head and neck(FACT-HN)were evaluated and compared. Results The incidences of anxiety and depression were significantly different between the control and intervention groups(anxiety: 42.1% vs. 15.9% with χ2=6.933, P=0.013; depression: 39.5% vs. 9.1% with χ2=10.573, P=0.001). The scores of the SAS, SDS, and ADHS had significant differences in the two groups based on dependent t-tests(SAS: 49.2±10.3 vs. 41.3±8.7 with t=3.77, P<0.001; SDS: 47.4±9.2 vs. 40.5±7.0 with t=3.85, P<0.001; ADHS: 27.1±7.8 vs. 34.7±6.9 with t=4.68, P<0.001). In the SF-36 scale, besides general health and vitality, the other six dimensions including physical functioning, role-physical, bodily pain, social functioning, role-emotional, and mental health in the intervention group were significantly higher than those in the control group(t=2.31, 2.54, 4.15, 2.66, 3.59, and 2.59, respectively; P=0.02, =0.01, <0.001, =0.01, <0.001, and =0.01, respectively). In the QLQ-C30 scale, significant differences in overall health status, five functioning scales(including body, cognition, role, emotions, and social function), and two single items(including insomnia and anorexia)were observed between the two groups(overall health status: t=2.42, P=0.02; five functioning scales: t=3.06, 3.95, 2.27, 2.23, and 0.01, respectively; P<0.001, <0.001, =0.03, =0.03, and =0.01, respectively; two single items: t=2.69 and 2.33, respectively; P=0.01 and 0.02, respectively). The total scores of FACT-HN and three dimensions(including social/family status, emotional well-being, and additional attention)were significantly different between the two groups(FACT-HN scores: 110.3±12.2 vs. 118.6±13.6, t=2.89, P=0.01; three dimensions: t=2.55, 3.07, and 2.14, respectively, P=0.01, <0.01, and =0.04, respectively). Conclusion Continuous out-of-hospital administration has certain positive significance in correcting psychological problems and promotes a sense of gain and quality of life in patients with laryngeal cancer.

Key words: Laryngeal neoplasms, Out-of-hospital administration, Emotions, Quality of life