Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (5): 70-74.doi: 10.6040/j.issn.1673-3770.0.2021.043

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Study on the value of tumor abnormal protein in clinical diagnosis of laryngeal carcinoma

LI Yanjie1, JIA Jian2, YANG Ping2, WAN Baoluo1   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, The People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China;
    2. Department of Otolaryngology, People's Hospital of Xixian, Xixian 464300, Henan, China
  • Published:2021-09-29

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Abstract: Objective Detection of tumor abnormal protein in patients with laryngeal cancer and healthy people was conducted to analyze the clinical value of tumor abnormal protein in the diagnosis of laryngeal cancer. Methods A total of 95 patients with laryngeal cancer diagnosed in pathology department, People's Hospital from September 2017 to September 2019 were selected as the experimental group, while 95 healthy patients were selected as the control group. All subjects were tested for tumor abnormal protein to explore its application value in the clinical diagnosis of patients with laryngeal cancer. Results The positive rate of tumor abnormal protein in patients with laryngeal cancer was 83.16%, which was higher than that in healthy people(15.79%), and the difference was statistically significant(P<0.001).The positive expression rate of TAP in peripheral blood of patients with lymph node metastasis and stage Ⅲ+Ⅳ laryngeal cancer was higher, and the difference was statistically significant(P<0.05).There was no significant difference in the expression level of abnormal tumor protein in peripheral blood of laryngeal cancer patients with different genders and ages(P>0.05). Conclusion The expression of tumor abnormal protein in peripheral blood of patients with laryngeal cancer has high sensitivity, and tumor abnormal protein has high application value in the clinical diagnosis of laryngeal cancer.

Key words: Tumor abnormal protein, Laryngeal cancer, The value of research

CLC Number: 

  • R739.65
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