Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (5): 93-97.doi: 10.6040/j.issn.1673-3770.0.2020.466

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Advancements of HIF-1α and VEGF in middle ear cholesteatoma

FAN Huijuan1,ZHANG Haili2   

  1. 1. Department of Clinical Medicine, The First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, China;
    2. Department of Otorhinolaryngology & Head and Neck Surgery, The First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, China
  • Published:2021-09-29

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Abstract: Cholesteatoma of the middle ear is an aggressive disease mainly composed of keratin fragments, keratinized squamous epithelium and its surrounding connective tissue. It is influenced by many factors and its pathogenesis is unclear.With the progress of science and technology, researchers began to study the pathogenesis of middle ear cholesteatoma from the aspect of molecular biology.hypoxia-inducible factor 1 alpha(HIF - 1α)and vascular endothelial growth factor(VEGF)have a variety of biological functions, they may play important roles in the middle ear cholesteatoma.In this review, we summarized the biological characteristics of HIF-1α and VEGF, and their possible roles in proliferation, apoptosis, immune response and aggressive growth of middle ear cholesteatoma, so as to provide the possibility for understanding the role of HIF-1α and VEGF in the pathogenesis of cholesteatoma and the non-surgical treatment and drug development of middle ear cholesteatoma

Key words: Hypoxia-inducible factor 1 alpha, Vascular endothelial growth factor, Middle ear, Cholesteatoma

CLC Number: 

  • R764.21
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