Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (1): 48-54.doi: 10.6040/j.issn.1673-3770.0.2021.260

Previous Articles     Next Articles

Hearing loss in children after bacterial meningitis: a systematic review and meta-analysis

LIU Shanshan1, HAN Shujing2, WANG Xiaoxu1, LI Yanhong1, NI Xin1,2, ZHANG Jie1   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, National Center for Children's Health China / Beijing Children's Hospital, Capital Medical University, Beijing 100045, China;
    2. National Center for Children's Health China / Beijing Children's Hospital, Capital Medical University / Beijing Pediatric Research Institute / Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head & Neck Surgery, Beijing 100045, China
  • Published:2022-02-22

PDF (PC)

122

Abstract: Objective To systematically evaluate the risk factors for hearing loss after bacterial meningitis in children. Methods Electronic databases including PubMed, EMbase, Web of Science, CNKI, Sinomed, Wanfang data, and VIP were searched from inception to September 20, 2021 to gather studies published on hearing loss in children after bacterial meningitis. Two authors independently assessed the quality of the studies using the NOS Scale, and a meta-analysis was performed using Stata 16.0 software. Results Twelve studies(3 cohort and 9 case-control studies)measured hearing in a total of 2041 children with bacterial meningitis among whom 301 children suffered sensorineural hearing loss. Meta-analysis was performed for a total of 4 risk factors. Results showed that Streptococcus pneumoniae infection ［OR=2.70, 95%CI(1.89, 3.87), P<0.001］ and seizures ［OR=2.31, 95%CI(1.29, 4.14), P=0.005］ were risk factors for hearing loss after bacterial meningitis; age ≤ 1 year old ［OR=1.00, 95%CI(0.34, 2.97), P=0.998］ and sex ［OR=1.06, 95%CI(0.70, 1.58), P=0.794］ were not associated with hearing loss. Conclusion Current evidence shows that Streptococcus pneumoniae infection and seizures are risk factors for hearing loss after bacterial meningitis. For children with the above risk factors, special attention should be paid to their hearing, and follow-up should be strengthened.

Key words: Children, Bacterial meningitis, Hearing, Risk factors, Meta-analysis

CLC Number: 

  • R764.43+1
[1] de Jonge RCJ, Sanders MS, Terwee CB, et al. Independent validation of an existing model enables prediction of hearing loss after childhood bacterial meningitis[J]. PLoS One, 2013, 8(3): e58707. doi:10.1371/journal.pone.0058707.
[2] Fortnum HM. Hearing impairment after bacterial meningitis: a review[J]. Arch Dis Child, 1992, 67(9): 1128-1133. doi:10.1136/adc.67.9.1128.
[3] Koomen I, Grobbee DE, Roord JJ, et al. Hearing loss at school age in survivors of bacterial meningitis: assessment, incidence, and prediction[J]. PEDIATRICS, 2003, 112(5): 1049-1053. doi:10.1542/peds.112.5.1049.
[4] Wells GA. The newcastle-ottawa scale(NOS)for assessing the quality of non-randomised studies in meta-analyses[C]. 2014.
[5] Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis[J]. Stat Med, 2002, 21(11): 1539-1558. doi:10.1002/sim.1186.
[6] Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses[J]. BMJ, 2003, 327(7414): 557-560. doi:10.1136/bmj.327.7414.557.
[7] Copas J, Shi JQ. Meta-analysis, funnel plots and sensitivity analysis[J]. Biostatistics, 2000, 1(3): 247-262. doi:10.1093/biostatistics/1.3.247.
[8] Richner B, Hof E, Prader A. Hearing impairment following therapy of Haemophilus influenzae meningitis[J]. Helv Paediatr Acta, 1979, 34(5): 443-447. PMID: 316810.
[9] Ozdamar O, Kraus N, Stein L. Auditory brainstem responses in infants recovering from bacterial meningitis. Audiologic evaluation[J]. Arch Otolaryngol Chic Ill, 1983, 109(1): 13-18. doi:10.1001/archotol.1983.00800150017003.
[10] Dodge PR, Davis H, Feigin RD, et al. Prospective evaluation of hearing impairment as a sequela of acute bacterial meningitis[J]. N Engl J Med, 1984, 311(14): 869-874. doi:10.1056/nejm198410043111401.
[11] McIntyre P, Jepson R, Leeder S, et al. A population based study[J]. Med J Aust, 1993, 159(11/12): 766-772. doi:10.5694/j.1326-5377.1993.tb141344.x.
[12] Kapoor RK, Kumar R, Misra PK, et al. Brainstem auditory evoked response(BAER)in childhood bacterial meningitis[J]. Indian J Pediatr, 1996, 63(2): 217-225. doi:10.1007/BF02845247.
[13] Yeat SW, Mukari SZ, Said H, et al. Post meningitic sensori-neural hearing loss in children - alterations in hearing level[J]. Med J Malaysia, 1997, 52(3): 285-290. PMID: 10968099.
[14] Richardson MP, Reid A, Tarlow MJ, et al. Hearing loss during bacterial meningitis[J]. Arch Dis Child, 1997, 76(2): 134-138. doi:10.1136/adc.76.2.134.
[15] Woolley AL, Kirk KA, Neumann AM Jr, et al. Risk factors for hearing loss from meningitis in children[J]. Arch Otolaryngol Head Neck Surg, 1999, 125(5): 509. doi:10.1001/archotol.125.5.509.
[16] Cherian B, Singh T, Chacko B, et al. Sensorineural hearing loss following acute bacterial meningitis in non-neonates[J]. Indian J Pediatr, 2002, 69(11): 951-955. doi:10.1007/BF02726011.
[17] Kutz JW, Simon LM, Chennupati SK, et al. Clinical predictors for hearing loss in children with bacterial meningitis[J]. Arch Otolaryngol Head Neck Surg, 2006, 132(9): 941. doi:10.1001/archotol.132.9.941.
[18] Karanja BW, Oburra HO, Masinde P, et al. Risk factors for hearing loss in children following bacterial meningitis in a tertiary referral hospital[J]. Int J Otolaryngol, 2013, 2013: 1-9. doi:10.1155/2013/354725.
[19] Lucas MJ, Brouwer MC, van de Beek D. Neurological sequelae of bacterial meningitis[J]. J Infect, 2016, 73(1): 18-27. doi:10.1016/j.jinf.2016.04.009.
[20] Davis LE. Acute bacterial meningitis[J]. Continuum(Minneap Minn), 2018, 24(5): 1264-1283. doi:10.1212/con.0000000000000660.
[21] Eisenhut M. Evidence supporting the hypothesis that inflammation-induced vasospasm is involved in the pathogenesis of acquired sensorineural hearing loss[J]. Int J Otolaryngol, 2019, 2019: 4367240. doi:10.1155/2019/4367240.
[22] Prager O, Friedman A, Nebenzahl YM. Role of neural barriers in the pathogenesis and outcome of Streptococcus pneumoniae meningitis[J]. Exp Ther Med, 2017, 13(3): 799-809. doi:10.3892/etm.2017.4082.
[23] 魏馨雨, 杨方园, 杨军, 等. 耳源性细菌性迷路炎研究进展[J]. 山东大学耳鼻喉眼学报, 2020,34(5): 102-107. doi: 10.6040/j.issn.1673-3770.1.2020.067. WEI Xinyu, YANG Fangyuan, YANG Jun, et al. The progress of otogenic bacterial labyrinthitis research[J]. J Otolaryngol Ophthalmol Shandong Univ, 2020,34(5): 102-107. doi: 10.6040/j.issn.1673-3770.1.2020.067.
[24] Perny M, Solyga M, Grandgirard D, et al. Streptococcus pneumoniae-induced ototoxicity in organ of Corti explant cultures[J]. Hear Res, 2017, 350: 100-109. doi:10.1016/j.heares.2017.04.012.
[25] Nieto H, Dearden J, Dale S, et al. Paediatric hearing loss[J]. BMJ, 2017, 356: j803. doi:10.1136/bmj.j803.
[26] 龚树生, 熊伟. 疑难病例人工耳蜗植入[J]. 山东大学耳鼻喉眼学报, 2017,31(5): 4-9. doi: 10.6040/j.issn.1673-3770.1.2017.034. GONG Shusheng, XIONG Wei. Cochlear implantation in intractable cases[J]. J Otolaryngol Ophthalmol Shandong Univ, 2017,31(5): 4-9. doi: 10.6040/j.issn.1673-3770.1.2017.034.
[27] Klein M, Koedel U, Kastenbauer S, et al. Nitrogen and oxygen molecules in meningitis-associated labyrinthitis and hearing impairment[J]. Infection, 2008, 36(1): 2-14. doi:10.1007/s15010-007-7153-1.
[28] Eisenberg LS, Luxford WM, Becker TS, et al. Electrical stimulation of the auditory system in children deafened by meningitis[J]. Otolaryngol Head Neck Surg, 1984, 92(6): 700-705. doi:10.1177/019459988409200619.
[29] Axon PR, Temple RH, Saeed SR, et al. Cochlear ossification after meningitis[J]. Am J Otol, 1998, 19(6):724-729. doi: 10.1016/S0196-0709(98)90048-5.
[30] Worse L, Cayé-Thomasen P, Thomas Brandt C, et al. Factors associated with the occurrence of hearing loss after pneumococcal meningitis[J]. Clin Infect Dis, 2010, 51(8): 917-924. doi:10.1086/656409.
[31] Skinner LJ, Beurg M, Mitchell TJ, et al. Intracochlear perfusion of pneumolysin, a pneumococcal protein, rapidly abolishes auditory potentials in the Guinea pig cochlea[J]. Acta Oto-Laryngol, 2004, 124(9): 1000-1007. doi:10.1080/00016480410017125.
[32] Winter AJ, Comis SD, Osborne MP, et al. A role for pneumolysin but not neuraminidase in the hearing loss and cochlear damage induced by experimental pneumococcal meningitis in Guinea pigs[J]. Infect Immun, 1997, 65(11): 4411-4418. doi:10.1128/iai.65.11.4411-4418.1997.
[33] Pomeroy SL, Holmes SJ, Dodge PR, et al. Seizures and other neurologic sequelae of bacterial meningitis in children[J]. N Engl J Med, 1990, 323(24): 1651-1657. doi:10.1056/nejm199012133232402.
[34] Arditi M, Mason EO, Bradley JS, et al. Three-year multicenter surveillance of pneumococcal meningitis in children: clinical characteristics, and outcome related to penicillin susceptibility and dexamethasone use[J]. Pediatrics, 1998, 102(5): 1087-1097. doi:10.1542/peds.102.5.1087.
[35] Namani SA, Kuchar E, Koci R, et al. Early symptomatic and late seizures in Kosovar children with bacterial meningitis[J]. Childs Nerv Syst, 2011, 27(11): 1967-1971. doi:10.1007/s00381-011-1480-3.
[36] Fortnum H, Davis A. Hearing impairment in children after bacterial meningitis: incidence and resource implications[J]. Br J Audiol, 1993, 27(1): 43-52. doi:10.3109/03005369309077889.
[37] 陈曦, 刘耘, 郑艳, 等. 儿童细菌性脑膜炎致听觉损伤的临床特点[J]. 中华实用儿科临床杂志, 2013,28(24):1875-1877. doi: 10.3760/cma.j.issn.2095-428X.2013.24.011. CHEN Xi, LIU Yun, ZHENG Yan, et al. Clinical features of hearing damages caused by bacterial meningitis in children[J]. Chin J Appl Clin Pediatr, 2013,28(24):1875-1877. doi: 10.3760/cma.j.issn.2095-428X.2013.24.011.
[1] YANG Yang, WANG Xiaoxu, ZHANG Jie. Progress on diagnosis and treatment of middle ear cholesteatoma in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 1-6.
[2] GAO Xinzhong, LING Zongtong, SHEN Ling, LIU Pingfang, LIN Xin,XU Yangyang. Analysis of the efficacy of balloon eustachian tuboplasty combined with adenoidectomy in the treatment of otitis media with effusion in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 7-12.
[3] MA Ning, CHEN Min, LIU Wei, YANG Yang, SHAO Jianbo, HAO Jinsheng, LIU Bing, ZHANG Xiao, DUAN Xiaomin, ZHANG Qifeng, ZHANG Jie. Clinical characteristics and management of pediatric temporal bone fractures [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 13-19.
[4] PAN Linlin, FANG Xuhua, ZHAI Feng, GUI Yiding, BIAN Zhouliang, CHEN Jie. The correlation between arterial blood gas analysis and hearing screening results in neonates [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 20-24.
[5] HU Chunyan, DANG Panhong, ZHANG Rui, FAN Mengyun. Analysis of audiological and imaging characteristics of 149 children with unilateral sensorineural hearing loss [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 31-36.
[6] DANG Panhong, ZHANG Rui, HU Chunyan, WANG Jie, FAN Mengyun. Clinical analysis of facial nerve decompression via an external transmastoid-subtemporal labyrinth approach in eight children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 37-42.
[7] NI Kun, SUN Shibing, LI Xiaoyan. Application of 1 000 Hz acoustic immittance in hearing screenings of high-risk newborns [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 43-47.
[8] JIAO Xuemei, YANG Yang, LI Chunfeng, ZHANG Xiaolin. Effect of tympanic membrane insertion on the function of eustachian tube in children with secretory otitis media [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 60-63.
[9] WANG Pengpeng, GE Wentong, TANG Lixing, YANG Xiaojian, ZHANG Wei, XIAO Xiao, HAN Yang. Four cases of open rhinoplasty approach for congenital nasal dermoid and sinus cysts in children and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 64-69.
[10] LI Menghui, ZHI Lili, QI Kaiwen, WANG Shanshan, GAO Qian, BU Meiling,. Clinical research of subcutaneous immunotherapy on children with allergic asthma caused by dust mites and combined with mold allergen [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 75-80.
[11] CHEN Kun, LU Hui, HUANG Qi, LI Lei, MENG Guozhen, YANG Jun, HOU Dongming. Clinical diagnosis and treatment of congenital nasal sinus mass in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 81-85.
[12] SHI Xiaoli, MU Hong. Multidisciplinary diagnosis and treatment of a child with severe obstructive sleep apnea syndrome complicated by pulmonary hypertension [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 116-119.
[13] ZHAO Xinghe, FAN Mingyue, DOU Xunwu, JIA Guangbiao. Primary large B-cell lymphoma of tonsil in children: a case report and document review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 120-124.
[14] PAN Linlin, KONG LingyiOverview,ZHAI Feng, CHEN JieGuidance. Research progress on auditory risk factors and hearing screening methods among neonates [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 131-137.
[15] YUAN Chenyang, LIU YanOverview,FANG ZhenshengGuidance. Advances on the effect of OSAHS on pulmonary function in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 143-148.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd