Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 189-194.doi: 10.6040/j.issn.1673-3770.0.2021.512

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Postoperative efficacy of proton pump inhibitor in the treatment of difficult-to-treat rhinosinusitis with laryngopharyngeal reflux

ZENG Xianting, WANG Guangke, SUN Zhanwei, WU Tianyi, LI Shichao, WANG Weiwei   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Henan Provincial People's Hospital/People's Hospital of Henan University, Henan Provincial People's Hospital, Zhengzhou 540000, Henan, China
  • Published:2022-06-15

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Abstract: Objective To explore the clinical effect of proton pump inhibitor(PPI)after the operation for difficult-to-treat rhinosinusitis(DTRS)with laryngopharyngeal reflux(LPR). Methods A total of 42 patients with DTRS with LPR were collected, of which 21 patients were given standard PPI treatment for 8 weeks plus routine perioperative treatment(experimental group), and 21 patients were given routine perioperative treatment(control group). The general information, peripheral blood eosinophil count, VAS score, peripheral blood IgE, Lund-Kennedy nasal endoscopy score, Lund-Mackay CT score, reflux symptom index scale(RSI)and reflux sign score(RFS)were compared between the two groups. The nasal endoscopic score, sinus CT score, VAS score, RSI and RFS scores of both groups were collected at the 1st, 3rd, 6th and 12th month after operation. Differences between the throat symptom score and objective examination results of both groups were analyzed, and the postoperative clinical effect of PPI therapy on DTRS with LPR was evaluated. Results After 1 year continuous follow-up, RFS, RSI, endoscopic score, sinus CT score and VAS scores were significantly lower compared with the control group ［(2.57±1.54)points vs.(3.57±1.60)points,P=0.045<0.05;(2.86±1.59)points vs.(4.62±1.77)points,P=0.002<0.05;(3.43±1.93)points vs.(5.43±3.11)points, P=0.017;(1.00±0.78)points vs(2.10±1.09)points, P=0.018<0.05;(0.67±0.66)points vs.(1.24±0.83)points,P=0.001<0.05］ Conclusion PPI after operation for DTRS with LPR can obviously improve nasal symptoms, improve quality of life and reduce the symptoms and signs related to throat reflux, which can be used as an individualized treatment for these patients.

Key words: Difficult-to-treat rhinosinusitis, Proton pump inhibitors, Laryngopharyngeal reflux, Individualized treatment, Endoscopy, Follow-up

CLC Number: 

  • R765.4+1
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