Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (5): 18-23.doi: 10.6040/j.issn.1673-3770.0.2022.180

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Clinical value of high-frequency ultrasound in the diagnosis of lymph node metastasis in hypopharyngeal squamous cell carcinoma

CHEN Dongyan, QIAN Ye, WEI Dongmin, LI Wenming, XIA Tongliang, LEI Dapeng, PAN Xinliang   

  1. Department of Otorhinolaryngology, Qilu Hospital of Shandong University/National Health Commission Key Laboratory of Otorhinolaryngology (Shandong University), Jinan 250012, Shandong, China
  • Published:2022-09-20

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Abstract: Objective To evaluate the clinical value of high-frequency ultrasound in the diagnosis of cervical lymph node metastasis in hypopharyngeal squamous cell carcinoma. Methods Forty-seven patients with hypopharyngeal cancer who underwent neck lymph node dissection in the Department of Otolaryngology in Qilu Hospital of Shandong University were recruited. The postoperative pathological results were used as the gold standard. The Kappa value was used to reflect consistency between the results of the three methods and the gold standard, and sensitivity and specificity were used to evaluate the diagnostic effect of the three methods; Pearson's chi-square test was used to compare the sensitivity and specificity of the three methods. Results A total of 47 patients with hypopharyngeal cancer, all of whom had no distant metastasis, were included in the study. Among the three methods, the consistency between ultrasound and pathological examination was highest(Kappa=0.718). According to the postoperative pathological examination results, the sensitivity of ultrasound in the diagnosis of cervical lymph node metastasis in hypopharyngeal cancer was highest(91.9%). The sensitivity was higher than that of palpation, and the difference was statistically significant. The sensitivity of ultrasound also tended to be higher than that of enhanced CT(78.9%), but the difference was not statistically significant. Palpation showed the highest specificity(94.74%), followed by ultrasound(78.95%)and enhanced CT(61.11%); however, the difference was not statistically significant. Conclusion High-frequency ultrasonography has high sensitivity and specificity in the diagnosis of cervical metastatic lymph nodes in hypopharyngeal carcinoma, which has important implications for clinical diagnosis. As it is non-invasive, portable, and repeatable, high-frequency ultrasound can be used as a common clinical examination method for cervical lymph node metastasis in hypopharyngeal carcinoma.

Key words: High-frequency ultrasound, Hypopharyngeal carcinoma, Lymph node metastasis, Enhanced CT, Palpation

CLC Number: 

  • R739.63
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