Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (6): 45-50.doi: 10.6040/j.issn.1673-3770.0.2022.220

• 临床研究 • Previous Articles    

Effect of brimonidine tartrate 0.2% on visual quality after phaco and extended depth of focus intraocular lens implantation with dysphotopsia under mesopic condition

YU Tengfei1, LI Yansong1, LIU Zhen1, ZHOU Weiwei1, ZHU Yan2, ZHU Yuguang2   

  1. 1. School of Clinical Medicine, Weifang Medical University, Weifang 261053, Shandong, China;
    2. Eye Center, Affiliated Hospital of Weifang Medical University, Weifang 261053, Shandong, China
  • Published:2022-12-07

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Abstract: Objective To investigate the effect of brimonidine tartrate 0.2% ophthalmic solution on visual quality after phaco and extended depth of focus intraocular lens(EDOF IOL)implantation with dysphotopsia under mesopic conditions. Methods This prospective non-randomized study enrolled 21 eyes with dysphotopsia from 21 age-related cataract patients who underwent phacoemulsification and EDOF IOL implantatiosn. The pseudophakic eye was topically administered bromonidine tartrate 0.2% at 1 month follow-up after EDOF IOL implantation. Before and 2 hours, 4 hours after brimonidine tartrate drops was administered topically. Under mesopic conditions, OPD-Scan III was used to measure the objective visual quality, including the strehl ratio(SR), higher-order aberrations(HOA), spherical aberration(SA), coma and trefoil aberration. Intraocular pressure(IOP)was further measured with a non-contact tonometer. The pupil size was evaluated under mesopic conditions. Uncorrected distance visual acuity(UDVA)and the best corrected distance visual acuity(CDVA)were measured using a high-contrast projected logMAR chart. The Visual Functioning-14(VF-14)scale was used to assess visual functioning and vision-related functional impairment. Results Significant differences were observed in ocular HOA, SA and Trefoil, as well as in optical quality parameters(all P<0.05)after brimonidine tartrate 0.2% administration compared to baseline,. The visual quality improved and reached its optimum value 2 h after 0.2% brimonidine 0.2% administration, which lasted beyond 4 h after administration. The ocular Coma after administration did not significantly differ(P=0.570). Significant differences were observed in the mesopic pupil size at 2 and 4 hours after brimonidine administration compared with baseline(P<0.001). The mesopic pupil size reached its minimum value 2 h after brimonidine administration. IOP reduction was observed at 2 and 4 hours after brimonidine administration, showing significant differences compared with the baseline IOP(P<0.001). UDVA and CDVA did not significantly differ after brimonidine administration(P=0.051,P=0.063). The VF-14 scale demonstrated that symptoms of glare or halos could be eliminated after brimonidine administration in 67% of pseudophakic eyes, and was alleviated in 24% and did not improve in 5%. Conclusion Brimonidine tartrate 0.2% ophthalmic solution exerts an antimydriatic effect under mesopic conditions in patients with EDOF IOL implantation. Brimonidine tartrate 0.2% may be applied to improve night visual quality in pseudophakic eyes through reducing ocular HOA, SA and Trefoil, increasing SR, and alleviating symptoms of glare or halos in pseudophakic eyes.

Key words: Extended depth of focus intraocular lens, Visual quality, Brimonidine tartrate, Dysphotopsia

CLC Number: 

  • R776.1
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