Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (6): 30-38.doi: 10.6040/j.issn.1673-3770.0.2024.075

• Research Progress • Previous Articles    

Diagnosis and treatment of gastroesophageal airway reflux disease: based on related consensus and guidelines from 2020 to 2024

HU Zhiwei1, CHEN Dong1, YANG Dong2, WU Jimin1   

  1. 1. Department of Gastroesophageal Surgery, Rocket Force Characteristic Medical Center, Beijing 100088, China2. Department of Surgery, 96608 Hospital of the People's Liberation Army, Hanzhong 723100, Shaanxi, China
  • Published:2024-12-13

PDF (PC)

171

Abstract: In recent years, airway diseases caused by gastroesophageal reflux have become a clinical hotspot in disciplines such as gastroenterology, otolaryngology, respiratory and gastrointestinal surgery, and new clinical evidence has been obtained. Consensus and guidelines related to gastroesophageal airway reflux diseases have been frequently released in recent years. These consensus and guidelines represent the latest progress in clinical research and treatment of reflux related disease. This review interprets the main consensus and guidelines related to reflux in recent years, and outlines the pathogenesis, clinical manifestations, diagnosis, and treatment strategies of gastroesophageal airway reflux disease.

Key words: Gastroesophageal airway reflux disease, Gastroesophageal reflux disease, Laryngopharyngeal reflux disease, Endoscopy, Reflux monitoring, Fundoplication

CLC Number: 

  • R573
[1] 中国医师协会外科医师分会胃食管反流病专业委员会. 胃食管反流病外科诊疗共识(2019版)[J]. 中华胃食管反流病电子杂志, 2019, 6(1): 3-9. doi:10.3877/cma.j.issn.2095-8765.2019.01.003 Chinese Committee of Gasstroesphageal Reflux Disease. Consensus on Surgical diagnosis and treatment of gastroesophageal reflux disease[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2019, 6(1): 3-9. doi:10.3877/cma.j.issn.2095-8765.2019.01.003
[2] 胡志伟, 吴继敏, 汪忠镐. 胃食管气道反流性疾病的诊断学概述[J]. 中国医学文摘(耳鼻咽喉科学), 2018, 33(1): 47-52, 42. doi:10.19617/j.issn1001-1307.2018.01.047 HU Zhiwei, WU Jimin, WANG Zhonggao. Diagnostics of gastroesophageal reflux disease[J]. Chinese Medical Digest(Otorhinolaryngology), 2018, 33(1): 47-52, 42. doi:10.19617/j.issn1001-1307.2018.01.047
[3] 中华耳鼻咽喉头颈外科杂志编辑委员会咽喉组, 中华医学会耳鼻咽喉头颈外科学分会咽喉学组, 中华医学会耳鼻咽喉头颈外科学分会嗓音学组. 咽喉反流性疾病诊断与治疗专家共识(2022年,修订版)[J]. 中华耳鼻咽喉头颈外科杂志, 2022, 57(10):1149-1172. doi:10.3760/cma.j.cn115330-20220711-00428
[4] Katz PO, Dunbar KB, Schnoll-Sussman FH, et al. ACG clinical guideline for the diagnosis and management of gastroesophageal reflux disease[J]. Am J Gastroenterol, 2022, 117(1): 27-56. doi:10.14309/ajg.0000000000001538
[5] Gyawali CP, Yadlapati R, Fass R, et al. Updates to the modern diagnosis of GERD: Lyon consensus 2.0[J]. Gut, 2024, 73(2): 361-371. doi:10.1136/gutjnl-2023-330616
[6] Hu ZW, Wu JM, Wang ZG, et al. Chinese consensus on multidisciplinary diagnosis and treatment of gastroesophageal reflux disease 2022[J]. Gastroenterol Endosc, 2023, 1(2): 33-86. doi:10.1016/j.gande.2023.01.001
[7] 吴玮, 王刚, 徐小杭, 等. 胃食管气道反流性疾病提出的依据及意义[J]. 中国医学文摘(耳鼻咽喉科学), 2018, 33(1): 14-17. doi:10.19617/j.issn1001-1307.2018.01.014 WU Wei, WANG Gang, XU Xiaohang, et al. Evidence and significance of gastroesophago-airway reflux disease[J]. Chinese Medical Digest(Otorhinolaryngology), 2018, 33(1): 14-17. doi:10.19617/j.issn1001-1307.2018.01.014
[8] Lechien JR, Vaezi MF, Chan WW, et al. The Dubai definition and diagnostic criteria of laryngopharyngeal reflux: the IFOS consensus[J]. Laryngoscope, 2024, 134(4): 1614-1624. doi:10.1002/lary.31134
[9] Krause AJ, Yadlapati R. Review article: diagnosis and management of laryngopharyngeal reflux[J]. Aliment Pharmacol Ther, 2024, 59(5): 616-631. doi:10.1111/apt.17858
[10] Sawada A, Sifrim D, Fujiwara Y. Esophageal reflux hypersensitivity: a comprehensive review[J]. Gut Liver, 2023, 17(6): 831-842. doi:10.5009/gnl220373
[11] Lu GW, Ding X, Xu W. Association between laryngopharyngeal reflux and vocal fold leukoplakia[J]. ORL J Otorhinolaryngol Relat Spec, 2021, 83(3): 159-166. doi:10.1159/000512527
[12] 黄辉强. 质子泵抑制剂对治疗声带白斑的疗效观察[J]. 中国医学文摘(耳鼻咽喉科学), 2021, 36(6): 126-127. doi:10.19617/j.issn1001-1307.2021.06.126 HUANG Huiqiang. Effect of proton pump inhibitors on leukoplakia of vocal cord[J]. Chinese Medical Digest(Otorhinolaryngology), 2021, 36(6): 126-127. doi:10.19617/j.issn1001-1307.2021.06.126
[13] 王宏艳, 王三春, 滕博, 等. 阻塞性睡眠呼吸暂停综合征与咽喉反流性疾病相关研究进展[J]. 山东大学耳鼻喉眼学报, 2020, 34(4): 134-138. doi:10.6040/j.issn.1673-3770.0.2019.565 WANG Hongyan, WANG Sanchun, TENG Bo, et al. Advances in the study of obstructive sleep apnea syndrome and laryngopharyngeal reflux disease[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 134-138. doi:10.6040/j.issn.1673-3770.0.2019.565
[14] 吴彦桥, 梁芳芳. 咽喉反流性鼻炎的临床初步研究[J]. 临床耳鼻咽喉头颈外科杂志, 2016, 30(3): 200-202. doi:10.13201/j.issn.1001-1781.2016.03.007 WU Yanqiao, LIANG Fangfang. Clinical pilot study on the rhinitis due to laryngopharyngeal reflux[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2016, 30(3): 200-202. doi:10.13201/j.issn.1001-1781.2016.03.007
[15] Kamal AN, Dhar SI, Bock JM, et al. Best practices in treatment of laryngopharyngeal reflux disease: a multidisciplinary modified Delphi study[J]. Dig Dis Sci, 2023, 68(4): 1125-1138. doi:10.1007/s10620-022-07672-9
[16] 李建房, 赵新涛. 纤维喉镜用于食管检查209例[J]. 山东大学耳鼻喉眼学报, 2012, 26(2): 74-75, 79. doi:10.6040/j.issn.1673-3770.2012.02.026 LI Jianfang, ZHAO Xintao. Fiberoptic laryngoscopy to examine the esophagus in 209 cases[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2012, 26(2): 74-75, 79. doi:10.6040/j.issn.1673-3770.2012.02.026
[17] 王菁, 邴雪, 陈宇帆, 等. 胃镜结合窄带成像技术提高下咽及喉部病变检出率的研究[J]. 现代消化及介入诊疗, 2023, 28(3): 287-290. doi: 10.3969/j.issn.1672-2159.2023.03.003 WANG Jing, BING Xue, CHEN Yufan, et al. A study on gastroscopy combining with narrow band imaging to improve the detection rate of hypopharyngeal and laryngeal lesions[J]. Modern Interventional Diagnosis and Treatment in Gastroenterology, 2023, 28(3): 287-290. doi: 10.3969/j.issn.1672-2159.2023.03.003
[18] 陈尔东, 王明涛, 李雪松, 等. 胃镜检查过程中咽喉部检查的诊断价值[J]. 中华消化内镜杂志, 2007, 24(6): 463-464. doi:10.3760/cma.j.issn.1007-5232.2007.06.027 CHEN Erdong, WANG Mingtao, LI Xuesong, et al. Diagnostic value of throat examination during gastroscopy[J]. Chinese Journal of Digestive Endoscopy, 2007, 24(6): 463-464. doi:10.3760/cma.j.issn.1007-5232.2007.06.027
[19] Xiao YL, Wu JCY, Lu CL, et al. Clinical practice guidelines for esophageal ambulatory reflux monitoring in Chinese adults[J]. J Gastroenterol Hepatol, 2022, 37(5): 812-822. doi:10.1111/jgh.15785
[20] Jung HK, Tae CH, Song KH, et al. 2020 Seoul consensus on the diagnosis and management of gastroesophageal reflux disease[J]. J Neurogastroenterol Motil, 2021, 27(4): 453-481. doi:10.5056/jnm21077
[21] Chen YY, Wang CC, Lin YC, et al. Validation of pharyngeal acid reflux episodes using hypopharyngeal multichannel intraluminal impedance-pH[J]. J Neurogastroenterol Motil, 2023, 29(1): 49-57. doi:10.5056/jnm22047
[22] 王磊, 王刚, 吴玮, 等. 口咽、食管同步Dx-pH检测研究咽喉反流性疾病[J]. 山东大学耳鼻喉眼学报, 2019, 33(5): 101-106. doi:10.6040/j.issn.1673-3770.0.2019.114 WANG Lei, WANG Gang, WU Wei, et al. Simultaneous Dx-pH monitoring of the oropharynx and esophagus for laryngopharyngeal reflux disease research[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 101-106. doi:10.6040/j.issn.1673-3770.0.2019.114
[23] Lechien JR, Chan WW, Akst LM, et al. Normative ambulatory reflux monitoring metrics for laryngopharyngeal reflux: a systematic review of 720 healthy individuals[J]. Otolaryngol Head Neck Surg, 2022, 166(5): 802-819. doi:10.1177/01945998211029831
[24] Wang G, Wang L, Sun ZZ, et al. A comparison between W score and RYAN score in diagnosing laryngopharyngeal reflux disease[J]. J Voice, 2023, 8: S0892-S1997(23)00174-1. doi:10.1016/j.jvoice.2023.06.001
[25] Hungin AP, Yadlapati R, Anastasiou F, et al. Management advice for patients with reflux-like symptoms: an evidence-based consensus[J]. Eur J Gastroenterol Hepatol, 2024, 36(1): 13-25. doi:10.1097/MEG.0000000000002682
[26] 曾宪廷, 王广科, 孙占伟, 等. 伴咽喉反流的难治性鼻窦炎术后应用质子泵抑制剂的疗效观察[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 189-194. doi:10.6040/j.issn.1673-3770.0.2021.512 ZENG Xianting, WANG Guangke, SUN Zhanwei, et al. Postoperative efficacy of proton pump inhibitor in the treatment of difficult-to-treat rhinosinusitis with laryngopharyngeal reflux[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 189-194. doi:10.6040/j.issn.1673-3770.0.2021.512
[27] 贾岩峰, 杨春伟, 宋富春, 等. CO2激光联合质子泵抑制剂治疗复发性声带突肉芽肿的疗效观察[J]. 山东大学耳鼻喉眼学报, 2016, 30(5): 106-109. doi:10.6040/j.issn.1673-3770.0.2016.073 JIA Yanfeng, YANG Chunwei, SONG Fuchun, et al. Efficacy of CO2 laser combined with proton pump inhibitors in the treatment of recurrent vocal process granuloma[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2016, 30(5): 106-109. doi:10.6040/j.issn.1673-3770.0.2016.073
[28] 中华医学会消化病学分会. 2020年中国胃食管反流病专家共识[J]. 中华消化杂志, 2020, 40(10): 649-663. doi:10.3760/cma.j.cn311367-20200918-00558
[29] Iwakiri K, Fujiwara Y, Manabe N, et al. Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2021[J]. J Gastroenterol, 2022, 57(4): 267-285. doi:10.1007/s00535-022-01861-z
[30] Simadibrata DM, Lesmana E, Fass R. A systematic review and meta-analysis of the efficacy of vonoprazan for proton pump inhibitor-resistant gastroesophageal reflux disease[J]. J Gastroenterol Hepatol, 2024, 39(5): 796-805. doi:10.1111/jgh.16475
[31] Stefanidis D, Hope WW, Kohn GP, et al. Guidelines for surgical treatment of gastroesophageal reflux disease[J]. Surg Endosc, 2010, 24(11): 2647-2669. doi:10.1007/s00464-010-1267-8
[32] Slater BJ, Dirks RC, McKinley SK, et al. SAGES guidelines for the surgical treatment of gastroesophageal reflux(GERD)[J]. Surg Endosc, 2021, 35(9): 4903-4917. doi:10.1007/s00464-021-08625-5
[33] 胡志伟, 汪忠镐, 张美光, 等. 美国胃肠道和内镜外科医师协会胃食管反流病外科治疗指南解读:从2010到2021[J]. 中华普通外科杂志, 2022, 37(2): 152-156. doi:10.3760/cma.j.cn113855-20210905-00538 HU Zhiwei, WANG Zhonggao, ZHANG Meiguang, et al. Interpretation of American association of gastrointestinal and endoscopic surgeons' guidelines for surgical treatment of gastroesophageal reflux disease: from 2010 to 2021[J]. Chinese Journal of General Surgery, 2022, 37(2): 152-156. doi:10.3760/cma.j.cn113855-20210905-00538
[34] Lechien JR, Dapri G, Dequanter D, et al. Surgical treatment for laryngopharyngeal reflux disease: a systematic review[J]. JAMA Otolaryngol Head Neck Surg, 2019, 145(7): 655-666. doi:10.1001/jamaoto.2019.0315
[35] Morice D, Elhassan HA, Myint-Wilks L, et al. Laryngopharyngeal reflux: is laparoscopic fundoplication an effective treatment?[J]. Ann R Coll Surg Engl, 2022, 104(2): 79-87. doi:10.1308/rcsann.2021.0046
[36] Tustumi F, Bernardo WM, Mariano da Rocha JR, et al. Anti-reflux surgery for controlling respiratory symptoms of gastro-esophageal reflux disease: a systematic review and meta-analysis[J]. Asian J Surg, 2021, 44(1): 2-10. doi:10.1016/j.asjsur.2020.04.017
[37] 陈冬, 肖飞, 胡志伟, 等. 慢性咳嗽合并胃食管反流病和/或食管裂孔疝抗反流手术的疗效分析[J]. 中华胃食管反流病电子杂志, 2021, 8(1): 9-15. doi:10.3877/cma.j.issn.2095-8765.2021.01.002 CHEN Dong, XIAO Fei, HU Zhiwei, et al. Analysis of the effectiveness of anti-reflux surgery for chronic cough combined with gastroesophageal reflux disease and/or hiatal hernia[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2021, 8(1): 9-15. doi:10.3877/cma.j.issn.2095-8765.2021.01.002
[38] 胡志伟, 汪忠镐, 吴继敏, 等. 胃食管反流性喉痉挛的综合诊治: 附64例报道[J]. 医学研究与教育, 2018, 35(4): 11-18. doi:10.3969/j.issn.1674-490X.2018.04.003 HU Zhiwei, WANG Zhonggao, WU Jimin, et al. Comprehensive diagnosis and treatment of gastroesophageal reflux laryngospasm(Report of 64 cases)[J]. Medical Research and Education, 2018, 35(4): 11-18. doi:10.3969/j.issn.1674-490X.2018.04.003
[39] 胡志伟, 汪忠镐, 吴继敏, 等. 胃食管反流病合并食管裂孔疝及哮喘症状的腹腔镜外科治疗[J]. 中华疝和腹壁外科杂志(电子版), 2014, 8(5): 396-402. doi:10.3877/cma.j.issn.1674-392X.2014.05.001 HU Zhiwei, WANG Zhonggao, WU Jimin, et al. The effectiveness of laparoscopic surgery for gastroesophageal reflux disease complicated with hiatal hernia and asthmatic symptoms[J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2014, 8(5): 396-402. doi:10.3877/cma.j.issn.1674-392X.2014.05.001
[40] Hu ZW, Wang ZG, Zhang Y, et al. A preliminary investigation of anti-reflux intervention for gastroesophageal reflux related childhood-to-adult persistent asthma[J]. Ann Surg Innov Res, 2014, 8: 3. doi:10.1186/1750-1164-8-3
[41] 王峰, 吴继敏, 汪忠镐, 等. 单中心腹腔镜食管裂孔疝修补术992例[J]. 中华普通外科杂志, 2016, 31(9): 732-735. doi:10.3760/cma.j.issn.1007-631X.2016.09.012 WANG Feng, WU Jimin, WANG Zhonggao, et al. Laparoscopic repair for hiatal hernia: report of 992 cases in a single center[J]. Chinese Journal of General Surgery, 2016, 31(9): 732-735. doi:10.3760/cma.j.issn.1007-631X.2016.09.012
[42] Zhuang QJ, Tan ND, Chen SF, et al. Magnetic sphincter augmentation in treating refractory gastroesophageal reflux disease: a systematic review and meta-analysis[J]. J Dig Dis, 2021, 22(12): 695-705. doi:10.1111/1751-2980.13063]
[43] Ward MA, Ebrahim A, Kopita J, et al. Magnetic sphincter augmentation is an effective treatment for atypical symptoms caused by gastroesophageal reflux disease[J]. Surg Endosc, 2020, 34(11): 4909-4915. doi:10.1007/s00464-019-07278-9
[44] 李志刚. 磁性括约肌增强器治疗胃食管反流的中国经验[J]. 临床外科杂志, 2021, 29(8): 704-706. doi:10.3969/j.issn.1005-6483.2021.08.002 LI Zhigang. China's experience in treating gastroesophageal reflux with magnetic sphincter enhancer[J]. Journal of Clinical Surgery, 2021, 29(8): 704-706. doi:10.3969/j.issn.1005-6483.2021.08.002
[1] ZHENG Lu, CHENG Jie, OUYANG Hong, CHI Huaming, DU Jingdong. Intractable nosebleed due to haemophilia A: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 86-90.
[2] LI Meichen, CHEN Hailing, LI Yang, MA Dengdian. Mucocele of inferior turbinate: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 91-94.
[3] LI Hongjin, WANG Jian, LAI Yubin, XU Min, XUE Tao, CHEN Fuquan, ZHA Dingjun, CHEN Xiaodong. Evaluation of different surgical methods in the treatment of maxillary cysts [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 33-37.
[4] TANG Qiushuang, BAI Xinghua. Analysis of the association between the stomach and five orifices through gastroesophageal reflux disease [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 102-108.
[5] LIU Jiaxin, JIANG Ye, SONG Daoliang. Endoscopic transnasal fenestration for maxillary bone cysts: a report of nine cases and a review of the literature [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(2): 84-88.
[6] QIN Ming, SUN Zhanwei, WANG Weiwei, LI Shichao, WU Tianyi, WANG Guangke. Efficacy of alkaline isotonic saline in laryngopharyngeal reflux symptom-positive or finding score-positive patients with chronic rhinosinusitis following endoscopic sinus surgery [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 147-153.
[7] ZENG Xianting, WANG Guangke, SUN Zhanwei, WU Tianyi, LI Shichao, WANG Weiwei. Postoperative efficacy of proton pump inhibitor in the treatment of difficult-to-treat rhinosinusitis with laryngopharyngeal reflux [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 189-194.
[8] ZHANG Min, LIU Yongliang, SONG Daoliang, HAN Xuefeng, FENG Xinrong, ZHAO Yunpei. A comparative study on the treatment of severe chronic hypertrophic rhinitis by modified inferior turbinate plasty under nasal endoscopy and low-temperature plasma ablation with fracture displacement of the inferior turbinate [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(6): 83-88.
[9] WANG Xuechang, WANG Tao, REN Xin, ZHAO Mingjun. Analysis of the clinical efficacy of endoscopy-assisted intraoral removal of an elongated styloid process without tonsillectomy [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(4): 17-21.
[10] SUN Xiaohan, LI Na, CHEN Kaixuan, CHEN Min, YAN Shu, CHE Fei. Application of the ROE scale to the evaluation of the quality of life of patients with external nose deformity and nasal septum deviation before and after surgery [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(3): 87-91.
[11] LIANG Huimin, WANG Liqin, WAN Wenjin, SHI Sailei, YUAN Jing, SHEN Yujie, ZHANG Jiacheng, MAO Zefan, NI Jingzi, PAN Yiwen, CHEN Zhibin, CHENG Lei. COVID-19 prevention and control scheme in an ENT endoscopy unit in China [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(2): 88-92.
[12] XIE Shuhua, YANG Zhumei, LIU Huiru, DONG Jing. Value of NLR, LMR, and PLR in predicting chronic sinusitis recurrence after endoscopic sinus surgery [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(1): 54-57.
[13] Lei WANG,Gang WANG,Wei WU,Hongdan LIU,Bingxin XU,Xin LI,Haolun HAN,Baowei LI,Ruiying DING,Lianyong LI. Simultaneous Dx-pH monitoring of the oropharynx and esophagus for laryngopharyngeal reflux disease research [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 101-106.
[14] Haiying WANG. Clinical analysis of 43 cases of nasal septum correction by a two-line method of decompression using a nasal endoscope [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 166-168.
[15] Feiyan LU,Yongtian LU,Junwei ZHOU,Yuan LIU. Applied anatomy of endoscopic resection of the petrous apex through the transcanal infracochlear approach [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 62-68.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd