Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2025, Vol. 39 ›› Issue (1): 136-140.doi: 10.6040/j.issn.1673-3770.0.2023.250

• Review • Previous Articles    

Research progress on omalizumab targeted therapy for chronic sinusitis with nasal polyps

ZHANG Yunqiu, REN Xiumin, XU Ou, DONG Jinhui, WANG Jianxing   

  1. Department of Otorhinolaryngology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Heibei, China
  • Published:2025-01-17

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Abstract: Chronic rhinosinusitis with nasal polyps(CRSwNP)is a common chronic inflammatory disease with a complex etiology and incompletely understood pathogenesis. Some patients show persistent clinical manifestations, and it remains difficult to control symptoms after functional nasal endoscopic surgery and standardized treatment with high doses of nasal corticosteroids. Omalizumab is a novel recombinant humanized anti-IgE antibody that plays a crucial role in the targeted therapy of CRSwNP. Recent studies have demonstrated that omalizumab can effectively treat refractory CRSwNP in adults by blocking the signaling of the key cytokine IgE in type 2 inflammation. This article reviews the immune mechanism, treatment status, mechanism of action, clinical efficacy, and adverse reactions of omalizumab in the treatment of CRSwNP.

Key words: Chronic sinusitis with nasal polyps, Omalizumab, Immunoglobulin E, Targeted therapy

CLC Number: 

  • R765.4
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