Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2025, Vol. 39 ›› Issue (4): 186-192.doi: 10.6040/j.issn.1673-3770.0.2024.297

• Review • Previous Articles     Next Articles

Research status and progress in diagnosis and treatment of laryngeal inflammatory myofibroblastic tumor

SHI Jinlian1, LI Jianxing1, HUANG Yousheng2, LIN Mingxuan3, LIU Lingyun1, LU Yongtian4   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, Longhua District Central Hospital, Shenzhen 518110, Guangdong, China2. Department of Pathology, Longhua District Central Hospital, Shenzhen 518110, Guangdong, China3. Department of Otolaryngology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, Guangdong, China4. Department of Otorhinolaryngology & Head and Neck Surgery, The Second People's Hospital, Shenzhen 518035, Guangdong, China
  • Online:2025-07-20 Published:2025-08-11

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Abstract: Inflammatory myofibroblastic tumor(IMT)is a rare mesenchymal neoplasm that occurs predominantly in the lung, with laryngeal involvement being relatively rare. Clinical manifestations of laryngeal IMT typically include hoarseness and breathing difficulties, which, due to their non-specific nature, often lead to misdiagnoses as other laryngeal conditions. Pathologically, laryngeal IMT is predominantly composed of inflammatory cells such as giant cells, plasma cells, and lymphocytes, together with spindle-shaped tumor cells that exhibit phenotypes of smooth muscle cells or myofibroblasts. These cells are interspersed with varying degrees of cell density and vascular distribution. The definitive diagnosis of laryngeal IMT is based on a combination of imaging studies, pathological evaluation, and immunohistochemical testing.Surgical excision remains the treatment of choice for laryngeal IMT. For cases where surgery is not feasible or there is recurrence or metastasis, targeted therapies, such as ALK inhibitors, have shown potential benefits. Tumor size, staging, and extent of surgical resection are important prognostic factors. This article reviews recent research advancements in the pathogenesis, clinical characteristics, diagnostic methods, and treatment strategies for laryngeal IMT, with the aim of improving the precision of diagnosis and effectiveness of treatments for this condition.

Key words: Inflammatory myofibroblastic tumor, Larynx, Etiology, Pathology, Treatment

CLC Number: 

  • R767.19
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