Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2025, Vol. 39 ›› Issue (4): 42-48.doi: 10.6040/j.issn.1673-3770.0.2023.447

• Clinical Research • Previous Articles     Next Articles

Construction of a decision tree algorithm to predict the risk of radiation oral mucositis in nasopharyngeal carcinoma patients after radiotherapy

XU Fei, ZHU Guangxi, WANG Kexin   

  1. Radiotherapy room in oncology department, Shengjing Hospital of China Medical University, Shenyang 110022, Liaoning, China
  • Online:2025-07-20 Published:2025-08-11

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Abstract: Objective To construct a decision tree model for predicting the risk of radiation oral mucositis(ROM)in nasopharyngeal cancer patients after radiotherapy. Methods One hundred nasopharyngeal cancer patients admitted to the hospital from January 2022 to June 2023 were prospectively selected as study subjects, and the patients were categorized into <3 ROM(n=81)and ≥3 ROM(n=19)according to whether or not ≥3 ROM occurred. Risk factors for the occurrence of grade ≥3 ROM after radiotherapy in nasopharyngeal cancer patients were analyzed using univariate and multivariate logistic regression, and an associated decision tree prediction model was established. Results The incidence of ROM after radiotherapy in 100 nasopharyngeal cancer patients was 96.0%. Univariate and multifactorial logistic regression analyses showed that smoking, concurrent chemotherapy, albumin level <35 g/L, and oral pH <7.0 were independent risk factors for the occurrence of grade ≥3 ROM after radiotherapy in nasopharyngeal carcinoma patients, whereas the use of oral mucosal protectants was a protective factor(P<0.05). The results of the accuracy validation of the decision tree model constructed using it showed that the area under the working characteristic curve(ROC)(AUC)of its subjects was 0.924(95%CI: 0.901~0.946). Conclusion There are more influencing factors for the occurrence of grade ≥3 ROM after radiotherapy in nasopharyngeal cancer patients, and the decision tree model constructed based on the influencing factors has good predictive ability for the risk of grade ≥3 ROM after radiotherapy in nasopharyngeal cancer patients.

Key words: Nasopharyngeal cancer, Radiotherapy, Radiation oral mucositis, Decision tree

CLC Number: 

  • R739.6
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