Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (1): 35-39.doi: 10.6040/j.issn.1673-3770.0.2020.133

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Clinical characteristics and prognosis of sudden sensorineural hearing loss in post-irradiated nasopharyngeal carcinoma survivors: a report of 18 cases

TAN Yufang, YI Tianhua   

  1. Department of Otolaryngology and Head and Neck Surgery, the First Affiliated Hospital of Shaoyang University, Shaoyang 422001, Hunan, China
  • Published:2021-02-01

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Abstract: Objective The aim of this study is to analyze the clinical characteristics and prognosis of sudden sensorineural hearing loss(SSNHL)in post-irradiated nasopharyngeal carcinoma(NPC)survivors. Methods Medical records of 18 SSNHL patients diagnosed with NPC(NPC group)between January 2014 and May 2019 were reviewed and analyzed, including age, sex, side, treatment delay time, accompanying symptoms, hearing loss severity, audiogram pattern, interval between SSNHL and NPC, and post-treatment hearing outcome. Results Eighteen patients had unilateral hearing loss, including 10 right ears(55.56%)and 8 left ears(44.44%); the sex distribution comprised of 15 males(83.33%)and 3 females(16.67%); 11 ears(61.11%)were accompanied with tinnitus and 10 ears(55.56%)were accompanied with vertigo; 10 patients(55.56%)exhibited total deafness-type hearing loss, and 12 patients(66.67%)suffered severe or profound hearing loss. The rates of complete recovery, significant recovery, partial recovery, and no recovery after treatment, 1 month post-treatment, and 3 months post-treatment were 5.56%, 11.11%, 16.67%, 66.67%, 5.56%, 16.67%, 16.67%, 61.11%, and 5.56%, 11.11%, 22.22%, and 61.11%, respectively. No statistical difference was observed between the three groups(P>0.05). Hearing gains and contralateral hearing gains were 12.22±5.16 dB HL, 3.61±2.33 dB HL, 13.89±6.88 dB HL, 4.44±2.15 dB HL, 13.33±6.02 dB HL, and 3.89±2.58 dB HL, respectively, and hearing gains were higher than the contralateral hearing gains(P<0.05). Conclusion In this study, post-irradiated NPC survivors with SSNHL demonstrated a severe hearing loss with a high rate of accompanying vertigo, and most audiograms revealed total deafness. Although hearing recovery is poor, active treatment can still improve the hearing prognosis and can even be curative.

Key words: Nasopharyngeal carcinoma, Sudden sensorineural hearing loss, Radiotherapy, Clinical characteristics, Prognosis, Hearing loss

CLC Number: 

  • R739.6
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