JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2014, Vol. 28 ›› Issue (4): 77-80.doi: 10.6040/j.issn.1673-3770.0.2013.318

Previous Articles     Next Articles

Expression and significance of insulin-like growth factor-1 and extracellular-signal regulated kinase1/2 in human glomus jugular tumor

SHENG Hong-shen1, HE Yue1, HUANG De-liang2, HAN Dong-yi2, YANG Shi-ming2, DAI Pu2, WU Wen-ming2   

  1. 1. Department of Otolaryngology, Chengdu Military General Hospital, Chengdu 610083, Sichuan, China;
    2. Department of Otolaryngology & Head and Neck Surgery, General Hospital of PLA, Beijing 100853, China
  • Received:2013-11-10 Online:2014-08-16 Published:2014-08-16

PDF (PC)

307

Abstract: Objective To investigate the expressions and significance of insulin-like growth factor-1(IGF-1) and extracellular-signal regulated kinase1/2(ERK1/2) in human glomus jugular tumor. Methods Immunohistochemistry was used to detect the expressions of IGF-1, ERK1 and ERK2 in 33 cases of human glomus jugular tumor and 9 cases of normal adrenal medulla. Results The expressions of IGF-1were found in 26 cases of glomus jugular tumor in which the expressions located mostly in the cytoplasm of chief cells while some in the nucleus. The expressions of IGF-1 were found in 5 cases of adrenal medulla which located mostly in the cytoplasm. The expressions of ERK1 and ERK2 were found in 24 and 25 cases of glomus jugular tumor with similar distribution restricted in the cytoplasm of chief cells. The expression of ERK1 and ERK2 were found in 4 and 5 cases of adrenal medulla with the pattern restricted in the cytoplasm. Overall, the expression intensities for IGF-1, ERK1and ERK2 in glomus jugular tumor cases were higher than those in the adrenal medulla cases. Furthermore, the expression of IGF-1 was significantly correlated with those of ERK1 and ERK2(r=0.553, 0.601, P<0.05). Conclusion The overexpression of IGF-1 may play an important role in tumor genesis and development via ERK1/2 signal pathway through a paracrine or autocrine manner in human glomus jugular tumors.

Key words: Glomus jugular tumor, Insulin-like growth factor-1, Extracellular-signal regulated kinase1/2

CLC Number: 

  • R730.2
[1] Gallagher E J, LeRoith D. The proliferating role of insulin and insulin-like growth factors in cancer[J]. Trends Endocrinol Metab, 2010, 21(10):610-618.
[2] Li S L, Goko H, Xu Z D, et al. Expression of insulin-like growth factor (IGF)-Ⅱ in human prostate, breast, bladder, and paraganglioma tumors[J]. Cell Tissue Res, 1998, 291(3):469-479.
[3] Kontogeorgos G, Scheithauer B W, Kovacs K, et al. Growth factors and cytokines in paragangliomas and pheochromocytomas, with special reference to sustentacular cells[J]. Endocr Pathol, 2002, 13(3):197-206.
[4] 于萍, 步宏, 王华, 等. 免疫组化结果的图像分析与人工计数方法的对比研究[J]. 生物医学工程学杂志, 2003, 20(2):288-290.
[5] Pavelić J, Matijević T, Knezević J. Biological & physiological aspects of action of insulin-like growth factor peptide family[J]. Indian J Med Res, 2007, 125(4):511-522.
[6] Rosenzweig S A, Atreya H S. Defining the pathway to insulin-like growth factor system targeting in cancer[J]. Biochem Pharmacol, 2010, 80(8):1115-1124.
[7] McCubrey J A, Steelman L S, Chappell W H, et al. Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance[J]. Oncotarget, 2012, 3(10):1068-1111.
[8] Wei F, Yan J, Tang D. Extracellular signal-regulated kinases modulate DNA damage response-a contributing factor to using MEK inhibitors in cancer therapy[J]. Curr Med Chem, 2011, 18(35):5476-5482.
[9] Roberts P J, Der C J. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer[J]. Oncogene, 2007, 26(22):3291-3310.
[10] 赵萌, 刘月平, 刘世正, 等.食管鳞癌中ERK及其活化形式蛋白的表达及意义[J]. 临床与实验病理学杂志, 2011, 27(11):1173-1176.
[11] 谷艳娇, 包翠芬, 魏嘉, 等.ERK1/2和p-ERK1/2在肺癌组织中的表达及意义[J]. 中国组织化学与细胞化学, 2009, 18(3):328-331.
[12] Ebisuya M, Kondoh K, Nishida E. The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity[J]. J Cell Sci, 2005, 118(14):2997-3002.
[1] ZHANG Ying, CHEN Hongmei, WU Xinyi.. Delayed corneal wound healing is related to impaired IGF-1 expression in diabetic rats. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(6): 74-78.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd