JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2014, Vol. 28 ›› Issue (5): 7-9.doi: 10.6040/j.issn.1673-3770.0.2014.186

Previous Articles     Next Articles

Changes of blood pressure in severe OSAHS patients with hypertension before and after Uvulopalatopharyngoplasty

WANG Yu-zhi, L Ling-yan, QU Zhe, WANG Xing-jie, ZHOU Xuan-yan   

  1. Department of Otolaryngology & Head and Neck Surgery, Liaocheng Second People's Hospital, Linqing 252600, Shandong, China
  • Received:2014-05-30 Published:2014-10-16

PDF (PC)

529

Abstract: Objective To investigate changes of blood pressure in the patients with severe obstructive sleep apnea hypopnea syndome(OSAHS) complicated with hypertension between before and after uvulopalatopharyngoplasty (UPPP). Methods 32 Patients suffering from severe OSAHS with hypertension were enrolled. All of them have taken oral antihypertensive drugs for more than three years and the blood pressure was poorly controlled. All the 32 patients were treated with modified UPPP. The polysomnograpy(PSG) and 24-hour dynamic blood pressure were monitored before operation and six months after operation. The results were compared. Results ①Six months after modified UPPP, median of apnea/hypopnea index(AHI)/Apnea index(AI)/ microarousal index(MAI)were all decreased obviously( P<0.05). The average SaO2 and lowest SaO2 were higher significantly (all P<0.05).②Six months after modified UPPP, the 24-hour average systolic blood pressure(SBP)/diastolic blood pressure (DBP), daily and nightly average SBP/DBP all were decreased obviously(P<0.05). Conclusion UPPP is good at blood pressure control for the patients with severe OSAHS complicated with hypertension.

Key words: Sleep Apnea, Obstructive, Hypertension, Uvulopalatopharyngoplasty

CLC Number: 

  • R766.7
[1] 叶京英,李彦如,李鹏鲲,等.改良悬雍垂腭咽成形术长期疗效的主观评价[J]. 中国耳鼻咽喉头颈外科,2011,18(2)： 90-94. YE Jingying, LI Yanru, LI Pengkun, et al.Long-term outcome of Han-uvulopalatopharyngoplasty with uvula reserved[J].Chin Arch Otolaryngol Head Neck Surgery, 2011, 18(2)： 90-94.
[2] 黄飞翔.阻塞性睡眠呼吸暂停综合征与高血压的关系[J].中西医结合心脑血管病杂志,2007,5(8)： 718-719. HUANG Feixiang. The relationship between obstructive sleep apnea syndrome and hypertension[J].Chin J Integrative Med Cardio/Cerebrovascular Disease, 2007, 5(8)： 718-719.
[3] Lavie P, Herer P, Hoffstein V. Obstructive sleep apnoea syndrome as a risk factor for hypertension: population study[J]. BMJ, 2000, 320(7233):479-482.
[4] Pedrosa R P, Drager L F, Gonzaga C C, et al. Obstructive sleep apnea: the most common secondary cause of hypertension associated with resistant hypertension[J].Hypertension, 2011, 58(5)：811-817.
[5] Chobanian A V, Bakris G L, Black H R, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report[J]. JAMA, 2003, 289(19)：2560-2572.
[6] Duran-Cantolla J, Aizpuru F, Montserrat J M, et al. Continuous positive airway pressure as treatment for systemic hypertension in people with obstructive sleep apnoea: randomised controlled trial [J].BMJ, 2010, 341：c5991.
[7] Barnes M, McEvoy R D, Banks S, et al. Efficacy of positive airway pressure and oral appliance in mild to moderate obstructive sleep apnea[J]. Am J Respir Crit Care Med, 2004, 170(6)：656-664.
[8] 郑涛,张丽,田广永,等.悬雍垂腭咽成形术对阻塞性睡眠呼吸暂停低通气综合征患者难治性高血压的影响[J].中华耳鼻咽喉头颈外科杂志,2012,47(5)：383-386. ZHENG Tao, ZHANG Li, TIAN Guangyong, et al. Effect of uvulopalatopharyngoplasty on obstructive sleep apnea hypopnea syndrome in patients with resistant hypertension[J]. Chin J Otorhinolaryngol Head Neck Surgery, 2012,47(5)：383-386.
[1] MA Xin, DONG Lingkang, WU Hongmin, YI Hongliang, ZOU Jianyin. Modifications and applications of lateral expansion abduction suspension suture technique in the treatment of obstructive sleep apnea [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 81-88.
[2] WANG Guifang, LI Rengao, MA Qing. Effects of H-UPPP combined with radiofrequency ablation of tongue root with low temperature plasma on oxygen saturation and arterial oxygen partial pressure in patients with OSAHS [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 49-54.
[3] WANG Teng, YU Lin, LI Sui. The correlation between γ-glutamyl transferase and obstructive sleep apnea syndrome-related hypertension [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(6): 80-84.
[4] YUAN Yuqi, CAO Zine, NIU Xiaoxin, XIE Yushan, SU Yonglong, ZHU Simin, ZHANG Yitong, LIU Haiqin, REN Xiaoyong, SHI Yewen. Clinical significance of peripheral blood inflammatory markers in obstructive sleep apnea hypopnea syndrome with hypertension [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(6): 85-92.
[5] CHEN Shangli, QIN Tao, CHEN Xuan, CHEN Ruojin, TANG Zhi. Association between homocysteine concentration and the MTHFR C677T polymorphism and hypertension in patients with obstructive sleep apnea hypopnea syndrome [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(4): 126-133.
[6] HAN Jibo, DONG Jie, MING Wei, WANG Yan, LUO Zhihong. The utility of different values of average oxygen saturation and minimum oxygen saturation between different sleep stages for predicting the uvulopalatopharyngoplastysurgery effect [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 73-78.
[7] SHI Xiaoli, MU Hong. Multidisciplinary diagnosis and treatment of a child with severe obstructive sleep apnea syndrome complicated by pulmonary hypertension [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 116-119.
[8] JI Di, DENG Anchun. Meta-analysis of the effect of surgery for obstructive sleep apnea hypopnea syndrome on blood pressure [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(6): 92-98.
[9] . Analysis of the preoperative predictive factors of Uvulopalatopharyngoplasty [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(5): 145-151.
[10] ObjectiveTo analyze the association between the classification of blood pressure and retinal vessel diameter measured by spectral-domain optical coherence tomography(SD-OCT). MethodsThis was a cross-sectional study that included 103 patients(103 eyes)with hypertension. Based on the classification of hypertension, the subjects were divided into three groups: the isolated systolic hypertension(ISH)(34 eyes), isolated diastolic hypertension(IDH)(34 eyes), and systolic combined with diastolic hypertension(SDH)(35 eyes)groups. Retinal vessel diameters were measured by SD-OCT. The differences among the central retinal arteriolar equivalents(CRAEs), the central retinal venular equivalents(CRVEs), and the artery-to-vein ratios(AVRs)of the three groups were analyzed. Multivariate logistic regression was performed to evaluate the association between blood pressure and AVR. ResultsThere were significant differences among the CRAEs and AVRs of the three groups(F=4.543, 4.308; P=0.013, 0.016). The CRAE and AVR of the SDH group were the lowest; those of the IDH group were the highest. There were no significant differences among the CRVEs of the three groups(F=0.417, P=0.660). After correction for risk factors, such as gender and age, multivariate logistic regression showed that patients with high systolic blood pressure were more likely to have AVRs of < 0.7 (OR=1.080, P=0.015). ConclusionsAmong the three types of hypertension, SDH was associated with the lowest CRAE and AVR. High systolic pressure is a risk factor for AVRs of < 0.7.. Association between the classification of blood pressure and retinal vessel diameter measured by SD-OCTFENG Xue1, WANG Haiwei2, LI Wensi1, YANG Xintong1, SUN Cun1, ZHAO Yuan1, ZHAO Pengbo1, ZHANG Jianqiang1 1. Department of Ophthalmology, Beijing Moslem People's Hospital, Beijing 100054, China; 2. Department of Ophthalmology, Fuxing Hospital, Capital Medical University, Beijing 100038, ChinaAbstract: [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 64-68.
[11] LIU Bei, LÜ Bochang, ZHU Zhongqiao, SUN Jianhua. Protective effect of puerarin on the optic nerve in rats with chronic intraocular hypertension [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(6): 98-103.
[12] SU Jie, AI Xin, MA Chunmei, YANG Fuyu, HUANG Shuai. Relationship between acute intraocular hypertension and lateral geniculate neuron autophagy and apoptosis in rats [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 68-71.
[13] HUO Hong, LI Wuyi, WANG Jian, YANG Dahai, JIN Xiaofeng, TIAN Xu, NIU Yanyan.. Treatment of pharyngeal stenosis following uvulopalatopharyngoplasty with coblation. [J]. J Otolaryngol Ophthalmol Shandong Univ, 2017, 31(6): 58-61.
[14] LIU Wenjun, YU Xueying, LÜ Dan, CHEN Zhenggang, ZHANG Yanqing, MEI Xubin, YANG Ke. Correlation between obstructive sleep apnea hypopnea syndrome and upper airway measurements of different genders. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 54-59.
[15] . Modified UPPP with low-temperature plasma tongue volume reduction and selective nasal cavity expansion for moderate to severe OSAHS: short-term efficacy and safety evaluation. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(1): 50-54.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd