JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2014, Vol. 28 ›› Issue (5): 23-26.doi: 10.6040/j.issn.1673-3770.0.2014.045

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Intratympanic steroids to treat refractory sudden sensorineural hearing loss(52 cases report)

YAN Xiao-ling, MAO Min, ZHAI Jin-ming, CHEN Guan-gui, ZHANG Jian-guo, LIU Qi-ming, XUE Jin-ping   

  1. Department of Otolaryngology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, Guangdong, China
  • Received:2014-02-08 Published:2014-10-16

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Abstract: Objective To investigate the effect of intratympanic steroids as a salvage method to treat the patients with refractory sudden sensorineural hearing loss who did not respond to initial primary systemic steroid therapy. Methods Reviews were performed for 96 patients hospitalized between 2010 and 2013. Among them, 52 patients accepted intratympanic steroids injection, and the remaining 44 patients who refused intratympanic treatment were served as the control group. Mean air conduction at four frequencies (0.5, 1, 2, and 4 kHz) were monitored. Hearing results was compared before and 1 month after the treatment. Results Hearing improvement was defined as more than 10 dB in pure tone average(PTA). The hearing improvement was 30.8%(16 cases) in the intratympanic group but 6.8%(3 cases) in the control (P<0.01). Conclusion Intratympanic steroid injection is an effective therapy for sudden sensorineural hearing loss patients who are refractory to primary systemic steroid therapy.

Key words: Sudden sensorineural hearing loss, Salvage treatment, Intratympanic, Dexamethasone

CLC Number: 

  • R764.43
[1] Khaimook W, Jantarapattana K.Therapy of idiopathic sudden sensorineural hearing loss with intratympanic steroid injection[J]. J Med Assoc Thai, 2011, 94(12):1495-1499.
[2] Filipo R, Covelli E, Balsamo G, et al. Intratympanic prednisolone therapy for sudden sensorineural hearing loss: a new protocol[J]. Acta Otolaryngol, 2010, 130(11):1209-1213.
[3] Hughes G B, Freedman M A, Haberkamp T J, et al. Sudden sensorineural hearing loss[J]. Otolaryngol Clin North Am, 1996, 29(3):393-405.
[4] Lazarini P R, Camargo A C. Idiopathic sudden sensorineural hearing loss: etiopathogenic aspects[J]. Braz J Otorhinolaryngol, 2006, 72(4):554-561.
[5] Wang Y W, Ren J H, Lu Y D, et al. Evaluation of intratympanic dexamethasone for treatment of refractory sudden sensorineural hearing loss[J]. J Zhejiang Univ Sci B, 2012, 13(3):203-208.
[6] Lee J D, Park M K, Lee C K, et al. Intratympanic steroids in severe to profound sudden sensorineural hearing loss as salvage treatment[J]. Clin Exp Otorhinolaryngol, 2010, 3(3):122-125.
[7] Silverstein H, Choo D, Rosenberg S I, et al. Intratympanic steroid treatment of inner ear disease and tinnitus (preliminary report)[J]. Ear Nose Throat J, 1996, 75(8):468-471, 474, 476 passim.
[8] Xenellis J, Papadimitriou N, Nikolopoulos T, et al. Intratympanic steroid treatment in idiopathic sudden sensorineural hearing loss: a control study[J]. Otolaryngol Head Neck Surg, 2006, 134(6):940-945.
[9] Ho H G, Lin H C, Shu M T, et al. Effectiveness of intratympanic dexamethasone injection in sudden-deafness patients as salvage treatment[J]. Laryngoscope, 2004, 114(7):1184-1189.
[10] Choung Y H, Park K, Shin Y R, et al. Intratympanic dexamethasone injection for refractory sudden sensorineural hearing loss[J]. Laryngoscope, 2006, 116(5):747-752.
[11] Hong S M, Park C H, Lee J H. Hearing outcomes of daily intratympanic dexamethasone alone as a primary treatment modality for ISSHL[J]. Otolaryngol Head Neck Surg, 2009, 141(5):579-583.
[12] Baysal E, Tun O, Baglam T, et al. Systemic steroid versus combined systemic and intratympanic steroid treatment for sudden sensorineural hearing loss[J]. J Craniofac Surg, 2013, 24(2):432-434.
[13] Wen Y H, Chen P R, Wu H P. Prognostic factors of profound idiopathic sudden sensorineural hearing loss[J]. Eur Arch Otorhinolaryngol, 2014, 271(6):1423-1429.
[14] Moon I S, Lee J D, Kim J, et al. Intratympanic dexamethasone is an effective method as a salvage treatment in refractory sudden hearing loss[J]. Otol Neurotol, 2011, 32(9):1432-1436.
[15] Erdur O, Kayhan F T, Cirik A A. Effectiveness of intratympanic dexamethasone for refractory sudden sensorineural hearing loss[J]. Eur Arch Otorhinolaryngol, 2014, 271(6):1431-1436.
[16] Salt A N, Ma Y. Quantification of solute entry into cochlear perilymph through the round window membrane[J]. Hear Res, 2001, 154(1-2):88-97.
[17] Saijo S, Kimura R S. Distribution of HRP in the inner ear after injection into the middle ear cavity[J]. Acta Otolaryngol, 1984, 97(5-6):593-610.
[18] She W, Dai Y, Du X, et al. Hearing evaluation of intratympanic methylprednisolone perfusion for refractory sudden sensorineural hearing loss[J]. Otolaryngol Head Neck Surg, 2010, 142(2):266-271.
[19] Ferri E, Frisina A, Fasson A C, et al. Intratympanic steroid treatment for idiopathic sudden sensorineural hearing loss after failure of intravenous therapy[J]. ISRN Otolaryngol, 2012, 19:647271.
[20] Tsai Y J, Liang J G, Wu W B, et al. Intratympanic injection with dexamethasone for sudden sensorineural hearing loss[J]. J Laryngol Otol, 2011, 125(2):133-137.
[21] Alatas N. Use of intratympanic dexamethasone for the therapy of low frequency hearing loss[J]. Eur Arch Otorhinolaryngol, 2009, 266(8):1205-1212.
[22] Sha S H, Taylor R, Forge A, et al. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals[J]. Hear Res, 2001, 155(1-2):1-8.
[23] Parnes L S, Sun A H, Freeman D J. Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application[J]. Laryngoscope, 1999, 109(7 Pt 2):1-17.
[24] Bird P A, Begg E J, Zhang M, et al. Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph[J]. Otol Neurotol, 2007, 28(8):1124-1130.
[25] Kakehata S, Sasaki A, Oji K, et al. Comparison of intratympanic and intravenous dexamethasone treatment on sudden sensorineural hearing losswith diabetes[J]. Otol Neurotol, 2006, 27(5):604-608.
[26] Li L, Ren J, Yin T, et al. Intratympanic dexamethasone perfusion versus injection for treatment of refractory sudden sensorineural hearing loss[J]. Eur Arch Otorhinolaryngol, 2013, 270(3):861-867.
[27] Chou Y F, Chen P R, Kuo I J, et al. Comparison of intermittent intratympanic steroid injection and near-continual transtympanic steroid perfusion as salvage treatments for sudden sensorineural hearing loss[J]. Laryngoscope, 2013, 123(9):2264-2269.
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