JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2015, Vol. 29 ›› Issue (5): 43-46.doi: 10.6040/j.issn.1673-3770.0.2015.290

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Valuation of the therapeutic effect of the nasal steroid hormone spray to detect EOS-CSF, IL-5 levels, EOS number of peripheral blood in allergic rhinitis patients

ZHANG Hui1, ZHENG Chengcai2, FENG Huiwei1, GUO Chenghao3   

  1. 1. Department of Otolaryngology & Head and Neck Surgery, The Second Hospital of Shandong Uuniversity, Jinan 250033, Shandong, China;
    2. Department of Otolaryngology, The Donggang Hospital of Rizhao City, Rizhao 276800, Shandong, China;
    3. The Medical School of Shandong University, Jinan 250012, Shandong, China
  • Received:2015-07-13 Revised:2015-09-21 Online:2015-10-16 Published:2015-10-16

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Abstract: Objective To detect the levels of eosinophil colony stimulating factor (EOS-CSF), interleukin-5(IL-5) and eosinophil(EOS) numbers in persistent moderately and severe allergic rhinitis patients'peripheral blood and to investigate the relationship between the levels of EOS-CSF and IL-5 and the clinic symptom of AR patients after using the Mometasone Furoate Aqueous Nasal Spray. Methods The levels of EOS-CSF and IL-5 in peripheral blood serum were detected by enzyme linked immunosorbent assay (ELISA). The number of EOS of fresh blood smear were observed by stained by Wright Giemsa method. The patients' nasal symptoms were evaluated by visual analogue scale. Results The levels of IL-5 and EOS-CSF and the EOS number in the AR group were significantly higher than in the normal control group.There was significant reduction of IL-5 and EOS-CSF in the patients after therapy. The data showed that the IL-5 level and EOS-CSF were positively correlated with EOS number. Conclusion Detection EOS-CSF, IL-5 and EOS number of peripheral blood in AR patients after treatment with nasal steroid hormone can be used to monitor the efficacy of treatment and provide guidance to adjust medication.

Key words: Allergic rhinitis, Interleukin 5, Eosinophil, Eosinophil colony stimulating factor

CLC Number: 

  • R765.4
[1] Brozek J L, Bousquet J, Baena-Cagnani C E, et al. Allergic rhinitis and its impact on asthma (ARIA) guidelines: 2010 Revision[J]. J Allergy Clin Immunol, 2010, 126(2):466-476.
[2] Seidman M D, Gurgel R K, Lin S Y, et al. Clinical practice guideline: allergic rhinitis[J]. Otolaryngol Head Neck Surg, 2015, 152(1 Suppl):S1-43.
[3] ZHAO J, BAI J, SHEN K, et al. Self-reported prevalence of childhood allergic diseases in three cities of China:a multicenter study[J]. BMC Public Health, 2010, 10(3):551-551.
[4] 欧阳昱晖,张罗,韩德民. 慢性嗜酸细胞性鼻及鼻窦炎[J].中国耳鼻咽喉头颈外科, 2010,17 (1):53-55. OUYANG Yuhui, ZHANG Luo, HAN Demin. Eosinophilic chronic rhinosinusitis[J]. Chin Arch Otolaryngol Head Neck Surgery, 2010, 17(1):53-55.
[5] 张辉,张大良,赵敬杰,等. 变应性鼻炎患者外周血嗜酸粒细胞一骨髓干细胞通路指标检测在激素治疗评价中的意义[J].中华耳鼻咽喉头颈外科杂志,2008,43(7):490-493. ZHANG Hui, ZHANG Daliang, ZHAO Jingjie, et al. Significance of the examination of path between eosinophils in peripheral blood and marrow stem cells for evaluating the effect of hormone therapy in patients with allergic rhinitis[J]. Chin J Otolaryngol Head Neck Surgery, 2008, 43(7):490-493.
[6] 张辉,张大良,郭成浩,等.变应性鼻炎患者外周血CD34和白介素5及嗜酸粒细胞的检测[J]. 中华耳鼻咽喉头颈外科杂志,2005,40(7):541-542. ZHANG Hui, ZHANG Daliang, GUO Chenghao, et al. detection of CD34, interleukin 5 and eosinophils in patients with allergic rhinitis in the peripheral blood[J]. Chin J Otolaryngol Head Neck Surgery, 2005, 40(7):541-542.
[7] 中华耳鼻咽喉科杂志编委会,中华医学会耳鼻咽喉科学分会. 变应性鼻炎的诊断和治疗指南[J].中华耳鼻咽喉头颈外科杂志,2009, 44(12):977-978. Editorial Board of Chinese Journal of Otorhinolaryngology, Chinese Medical Association of Otorhinolaryngology. Guidelines for the diagnosis and treatment of allergic rhinitis[J]. Chin J Otolaryngol Head Neck Surgery, 2009, 44(12):977-978.
[8] 施典羽,杨凯,敬光怀,等.布地奈德鼻喷剂对变应性鼻炎患者血中IL-5和IL-12的影响[J]. 安徽医学,2011,32(5):641-642. SHI Dianyu, YANG Kai, JING Guanghuai, et al. The effect of budesonide nasal spray on the IL-5 and IL-12 in the patients with allergic rhinitis[J]. Anhui Med, 2011, 32(5):641-642.
[9] Krouwels F H, Hol B E, Lutter R, et al. Histamine affects interleukin-4, interleukin-5, and interferon-gamma production by human T cell clones from the airways and blood[J]. Am J Resp Cell Mole Miol, 1998, 18(5):721.
[10] Sanderson C J. Interleukin-5, eosinophils, and disease[J]. Blood, 1992, 79(12):3101-3109.
[11] 燕志强,高盛宏,张俊,等.糖皮质激素对变应性鼻炎大鼠血清IL5、IL12、IL18含量变化的影响[J]. 解放军医学杂志,2009,34(10):1218-1220. YAN Zhiqiang, GAO Shenghong, ZHANG Jun, et al. Effect of glucocorticoid on the contents of IL-5, IL-12, IL-18 in allergic rhinitis rats[J]. Med J Chin PLA, 2009, 34(10):1218-1220.
[12] 韩德民.加强变应性鼻炎研究促进临床规范治疗[J].中华耳鼻咽喉头颈外科杂志,2006,41(7):481-482. HAN Demin. Strengthen the research of allergic rhinitis and promote the clinical standard treatment[J]. Chin J Otolaryngol Head Neck Surgery, 2006, 41(7):481-482.
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