JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2015, Vol. 29 ›› Issue (6): 71-73.doi: 10.6040/j.issn.1673-3770.0.2015.312

Previous Articles     Next Articles

Effect of glycosylated hemoglobin on dry eye in patients with type 2 diabetes mellitus

WANG Luping, WU Xinyi   

  1. Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2015-07-28 Online:2015-12-16 Published:2015-12-16

PDF (PC)

530

Abstract: Objective To evaluate the effect of glycosylated hemoglobin on dry eye in patients with type 2 diabetes mellitus. Methods A total of 140 patients with type 2 diabetes mellitus were collected and divided into two groups: poor in glucose control group (n=70) and good in glucose control group (n=70), according to the level of glycosylated hemoglobin A1c (HbA1c). All patients were inquired about dry eye svndrome and received the examinations as follows: Schirmer I test (SIt), tear break-up time (BUT) and corneal fluorescein staining (FL). Results The elderly and male patients of poor in glucose control group showed higher incidence of dry eye syndrome than that of good in glucose control group, showing a significant difference between two groups (P<0.05). The elderly patients of poor in glucose control group showed lesser SIt and faster BUT than controls (P<0.05); there were no differences among SIt, BUT in young and middle patients of two groups. HbA1c level was positively correlated with dry eye svndrome, and negatively correlated with SIt, BUT. Conclusion The HbA1c level was correlated with dry eye in elderly patients with type 2 diabetes mellitus. It has great clinical value by controlling the glycosylated hemoglobin levels on patients with type 2 diabetes mellitus.

Key words: Dry eye, Glycosylated hemoglobin A1c, Type 2 diabetes mellitus

CLC Number: 

  • R587.2
[1] 代庆红, 王忠东. 中国糖尿病的现状调查[J]. 中国医药指南, 2011, 9(13):206-208. DAI Qinghong, WANG Zhongdong. Current status of diabetes in China[J]. Guide Chin Med, 2011, 9(13):206-208.
[2] 朱姝, 贾卉. 2型糖尿病与干眼症的相关性分析[J]. 眼科研究, 2007, 25(8):602-604. ZHU Shu, JIA Hui. Analysis of correlation between type 2 diabetes mellitus and dry eye[J]. Chin Ophthalmol Res, 2007, 25(8):602-604.
[3] Xu K. Impaired epithelial wound healing and EGFR signaling pathways in the corneas of diabetic rats[J]. Invest Ophthalmol Vis Sci, 2011, 52(6):3301-3308.
[4] 朱奕睿, 陈蔚. 糖尿病相关干眼的研究进展[J]. 中华眼视光学与视觉科学杂志, 2014, 16(9):568-572. ZHU Yirui, CHEN Wei. Research progress on dry eye in diabetes mellitus[J]. Chin J Optom Ophthalmol Vis Sci, 2014, 16(9):568-572.
[5] 刘祖国.眼表疾病学[M].北京：人民卫生出版社，2003：288-289.
[6] 周秀敏, 胡蓉, 雷澄. 糖尿病性干眼的流行现状及危险因素的调查[J]. 中国临床护理, 2014, 6(1):69-71. ZHOU Xiumin, HU Rong, LEI Cheng. Epidemiologicalinvestigationandriskfactorsanalysisofdryeye withdiabetesmellitus[J]. ChinClinNurs, 2014, 6(1):69-71.
[7] 郑静, 姜世菊. 糖尿病患者合并干眼症及其与血糖水平的关系[J]. 检验医学与临床, 2014, 11(12):1653-1654. ZHENGJing, JIANGShiju. Thebloodsugarlevelsindiabeticpatientswithxerophthalmia[J]. LabMedClin, 2014, 11(12):1653-1654.
[8] Wu Y C. Elevated IGFBP3 levels in diabetic tears: a negative regulator of IGF-1 signaling in the corneal epithelium[J]. Ocul Surf, 2012, 10(2):100-107.
[9] Kim H J, Kim P K, Yoo H S, et al. Comparison of tear proteins between healthy and early diabetic retinopathy patients[J]. Clin Biochem, 2012, 45(1):60-67.
[10] Imam S, Elagin R B, Jaume J C. Diabetes-associated dry eye syndrome in a new humanized transgenic model of type 1 diabetes[J]. Molecular Vis, 2013, 19(10):1259-1267.
[1] YANG Xue, LI Ying. Impact of dry eye on corneal endothelial cell density and morphology [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 72-76.
[2] HU Jindong, LIU Xinquan. Research progress of dry eye animal model. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 109-113.
[3] JIANG Yang, LI Ying, WANG Zhonghai, JIN Yumei, LIU Xiaowei. Effect of the implantation of lacrimal plug for dry eyes after laser assisted in-situ keratomiLeusis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(2): 80-83.
[4] SHAO Na, ZHANG Han. Variation of visual acuity and fundus in type 2 diabetic patients after phacoemulsification surgery. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(1): 83-87.
[5] ZHANG Ju, WU Xin-yi. Effects of 01% cyclosporin eye drops in combination with sodium hyaluronate eye drops in the treatment of dry eye syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(1): 49-51.
[6] ZHU Wei1, MU Guo-ying2. Effect of different depth of corneal flap on dry eye syndrome after corneal refractive operation [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(5): 1-2.
[7] XIN Zhaoting1, YANG Shasha1,2, WU Xinyi1. Clinical analysis of risk factors of dry eye [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(4): 83-86.
[8] GUO Li1, YUAN Fang2, LI Bin1. Initial clinical observation of Smart Plug lacrimal plug in the treatment of aqueous tear deficiency dry eye [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(1): 63-66.
[9] CHEN Min, CAI Li-mei, CAI Fu-xu, WU Hui-ying. Prognosis of phacoemulsification in patients with dry eyes [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2009, 23(5): 61-63.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd