Abstract: Objective To explore the improvements of olfaction and quality of life(QOL)of the chronic rhinosinusitis(CRS)patients(with / without nasal polyps)with olfactory disorders. Methods 44 CRS patients with olfactory disorders were involved in this study and accepted CT scanning and Lund-Mackay CT score investigation before treatments. VAS score, SNOT-20 score and T&T test were taken before the operation, and 4 weeks and 12 weeks after the operation. Results In the T& T test, there were 59.5% and 73.0% of the patients whose olfaction were improved 4 and 12 weeks after the operation. The improvement rates were 77.3% and 86.4% in the VAS score. There were statistical difference between the pre-operation and post-operative 4 and 12 weeks(P<0.0001)in the T& T test and the VAS score, while the difference between the 4 weeks and 12 weeks after the operation were statistical insignificant(P=0.720,0.147). There was statistical difference between the pre-operation and post-operative 4 and 12 weeks(P<0.000 1)in the SNOT-20 test, while the difference between the 4 weeks and 12 weeks after the operation was statistically insignificant(P=0.055). Lund-Mackay CT score, T & T test, and VAS scores were positively correlated(r=0.569,P<0.000 1;r=0.782,P<0.000 1). Conclusion The olfaction and QOL of the patients significantly improve after endoscopic sinus surgery, and the difference between the 4 weeks and 12 weeks after the operation is statistically insignificant. The extent of the disease in the CRS and the degree of olfactory disorder are positively correlated.

Key words: T test, Endoscopic sinus surgical procedures, operative, Quality of life, Lund-Mackay CT score, Olfaction, Chronic rhinosinusitis, T&, SNOT-20 score