七叶皂苷钠联合小剂量泼尼松治疗亚急性甲状腺炎女性患者的疗效及安全性

doi:10.6040/j.issn.1673-3770.0.2015.381

Abstract

Abstract: Objective To investigate the efficacyt and safety of sodium aescinate combined with low dosage of prednisone in the treatment of female patients with subacute thyroiditis. Methods A total of 80 patients with subacute thyroiditis were collected and randomly divided into the observation group and control group, with 40 cases in either group. Patients in the control group were given a total dosage of 30 mg/d oral prednisone, divided into 3 times per day. Two weeks later these patients were given a total dosage of 20 mg/d oral prednisone, divided into 3 times per day. Then the dosage was reduced by 5 mg every 2 weeks till withdrawal. Patients in the observation group were treated with 5 mg/d oral prednisone combined with 10 mg/d intravenous sodium aescinate. A 10-day course was set with an interval of 7 days. The treatment lasted for 4 weeks. The levels of thyroid stimulating hormone(TSH), free three iodine thyroid original ammonia acid(FT3), free thyroxine(FT4), red cell sedimentation rate(ESR), C-reactive protein(CRP)and fibrinogen(FIB)before treatment, 7 days, 1 month and 2 months after treatment were compared. The symptom alleviating time and incidence of adverse reactions in both groups were observed. Results Intra-group comparison: FT3, FT4, ESR, CRP, TSH levels showed statistical significances at different time points before and after treatment in the 2 groups respectively(P<0.05 or P<0.01). Inter-group comparison: ESR, CRP, TSH levels were lower in the observation group than in the control group 7 days after treatment(P<0.05 or P<0.01). FT4 and ESR levels were lower in the observation group than in the control group 1 month after treatment(P<0.01). CRP and FIB levels were lower in the observation group than in the control group 2 months after treatment(P<0.05). The symptom alleviating time and incidence of adverse reactions were lower in the observation group than in the control group(P<0.01). Conclusion Sodium aescinate combined with low dosage of prednisone is safe and effective in the treatment of subacute thyroiditis and worth of wide clinical application.

Key words: Sodium aescinate, Prednisone, Subacute thyroiditis

CLC Number:

R581.4

LI Cunjie, SUN Yu. Clinical effect and safety of sodium aescinate combined with low dosage of prednisone in the treatment of female patients with subacute thyroiditis.[J].JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(2): 75-77.

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Clinical effect and safety of sodium aescinate combined with low dosage of prednisone in the treatment of female patients with subacute thyroiditis.

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