JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

• Articles • Previous Articles     Next Articles

Expression of ABAD/HADH Ⅱ in laryngeal squamous cell carcinoma and vocal polyp

ZHANG Hui-ping,ZHANG Peng-fei,SHANGGUAN Han-jing, LAN shu-zhan   

  1. 1. Department of Otolaryngology, Affiliated First Hospital of Fujian Medical University, Fuzhou 350004, Fujian, China; 2. Department of Pathology and Pathophysiology, Fujian Medical University, Fuzhou 350005
  • Received:2006-08-10 Revised:1900-01-01 Online:2006-10-24 Published:2006-10-24
  • Contact: ZHANG Hui-ping

Abstract: To determine the expression of ABAD/HADH Ⅱ in human laryngeal carcinoma and to investigate whether their expressions relate to proliferation of laryngeal carcinoma cells. Method: Expression of ABAD /HADH Ⅱ was detected in patients with laryngeal squamous cell carcinoma or vocal polyp by immunohistochemical method. Results： ABAD /HADH Ⅱ mainly expressed in the cytoplasm of laryngeal squamous cell cancinoma cells, especially of the proliferating cells. The immunohistochemistry result indicated that the expression of ABAD /HADH Ⅱ was significantly higher in the squamous cell cancinoma than in the vocal polyp (P<0.05). Conclusion: The expression of ABAD/HADH Ⅱ in the laryngeal squamous cell cancinomatissues is significantly higher than in the normal tissues, suggesting that ABAD /HADH Ⅱ may play a role in the proliferation of laryngeal squamous cell cancinoma.

Key words: Proliferation, ABAD/HADH Ⅱβ , Laryngeal neoplasms

[1] LI Guobin, ZHANG Zhancheng, WANG Xinyan. Up-regulation of miR-200b may inhibit epithelial mesenchymal transition process to prevent the proliferation, migration, and invasion of human laryngeal cancer Hep-2 cells [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 53-57.
[2] ZHOU Yibo, GONG Xiaorong, YU Feng. Effects of miR-150 targeted to Nanog on proliferation and invasion of nasopharyngeal carcinoma side population cells. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(5): 79-84.
[3] FU Yugui, WANG Hailan, SUN Dechong, YANG Peizhen, CHEN Yanlin, CHEN Zhipeng. Total laryngectomy with partial preservation of the cricoid cartilage ring. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 73-75.
[4] . Curcumin combined with resveratrol enhances their anti-tumoral effects in the head and neck carcinoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(2): 67-72.
[5] XU Yuanteng, CHEN Ruiqing, LIN Gongbiao, FANG Xiuling, YU Shujuan, LIANG Xiaohua, ZHANG Rong. Effect of silencing PDCD4 gene on proliferation of Hep-2 cells and the expression of β-catenin by RNA interference technique. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(5): 110-114.
[6] YAN Yu, ZHU Jiang. Advances in the diagnosis of early laryngeal carcinoma and precancerous laryngeal lesions. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(4): 80-85.
[7] CHEN Chunli, SONG Zongming, JIA Xinguo, ZHOU Zhonglou, WANG Zhaoyang. Erythropoietin inhibits Müller cell apoptosis induced by oxidative damage [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(3): 65-71.
[8] WEI Xi-jian1, YIN Rui-lan2, GUO Xing3. Expression of a proliferation-inducing ligand in laryngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(1): 14-16.
[9] LU Guo-wei， WANG Lin, SUN Yan， LI Wei， HUA Hui， GE Rui-feng. Detection of different subtypes of HPV DNA in 57 cases of laryngeal carcinoma in easter of the shandong province [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(6): 16-19.
[10] LI Da-wei, DONG Pin, GAO Shang. Significance of apoptotic and proliferative indices and  P-glycoprotein expression in laryngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(4): 8-12.
[11] CHEN Jian-qiu1,2, ZHU Min-hui1, QIU Xiao-xia1, XIA Si-wen1,YE Ben2, CHEN Shi-cai1, ZHENG Hong-liang1. Expressions and clinical significances of osteopontin and p53 in laryngeal squamous cell carcinoma tissues [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(2): 19-22.
[12] LI Zhi-zhang1, LI Qin2, GENG Yu-yan3， SHAO Yang1. Effect and significance of the TGF-β1/Smad4 signaling system in laryngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(2): 16-.
[13] GAO Shang, DONG Pin, LI Da-Wei, SHEN Bin. Potential mechanism of Platelet derived growth factor-BB to  promote the proliferation and invasion of Hep2 cells [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(1): 20-23.
[14] LI Da-wei, GAO Shang, CHEN Xin-wei, WANG Guo, DONG Pin. Expression and significance of hypoxia-inducible factor 1α and p-glycoprotein in laryngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(4): 6-9.
[15] LIU Zhang, SUN Yan, HUA Hui, CHEN Zhijun, LI Wei, SUN Wenhai. Clinical features of laryngeal carcinoma in females in the east of Shandong Province [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(2): 8-10.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd