JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (2): 55-58.doi: 10.6040/j.issn.1673-3770.0.2016.409

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Effects of concurrent chemotherapy and radiotherapy on the quality of life in children and adolescents with nasopharyngeal carcinoma.

  

  1. 1. Weifang Medical College, Weifang 261041, Shandong, China;2. Department of Otolaryngology, Weifang Peoples Hospital, Weifang 261041, Shandong, China
  • Received:2016-09-22 Online:2017-04-16 Published:2017-04-16

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Abstract: Objective To investigate the effects of concurrent chemotherapy and radiotherapy on the quality of life and adverse reactions in children and adolescents with nasopharyngeal carcinoma. Methods A total of 21 children and adolescents with nasopharyngeal carcinoma treated with concurrent chemotherapy and radiotherapy were surveyed with Pediatric Quality of Life Inventory 4.0 Generic Core Scales(Peds QLTM4.0)and Pediatric Quality of Life Inventory 3.0 Cancer Module(Peds QLTM3.0)questionnaires. The quality of life scores were calculated and toxic reactions were observed. Results After proper periods of concurrent chemoradiotherapy, patients’ quality of life dropped. In Peds QLTM4.0, the scores of physical, emotional and school functioning dimensions were markedly reduced(P<0.01), especially the school functioning item. In Peds QLTM3.0, such dimensions as pain, nausea, procedure anxiety, cognitive and communication were markedly lowered(P<0.01). Adverse reactions mainly included skin damage, mouth mucitis, dry mouth, nausea, vomiting and neutropenia. Conclusion More attention should be attached to childrens self-reported quality of life. The adverse reactions of concurrent chemoradiotherapy can significantly affect the quality of life. Targeted interventions are supposed to be taken to improve patients’ quality of life.

Key words: Concurrent chemotherapy and radiotherapy, Child, Adolescence, Quality of life, Nasopharyngeal carcinoma

CLC Number: 

  • R739.6
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