JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (5): 85-88.doi: 10.6040/j.issn.1673-3770.0.2017.187

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The effect of general anesthesia on postoperative cognitive function in patients with simple snoring.

GENG Cong1, ZHANG Liwei1, DING Ming2   

  1. 1. Anaesthesiology, Weifang Medical College, Weifang 261053, Shandong, China;2. Department of Anesthesiology, No.89 Hospital of Peoples Liberation Army, Weifang 261000, Shandong, China
  • Received:2017-05-02 Online:2017-10-16 Published:2017-10-16

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Abstract: Objective To assess the correlation between serum S100β protein and serum neuron-specific enolase(NSE)levels before and after general anesthesia in patients with simple snoring(SS)and investigate the effect of general anesthesia on the cognitive function of these patients before and after an operation. Methods Patients undergoing selective arthroscopy surgery under general anesthesia were divided into the SS(AHI<5, n1=30)and normal sleep(n2=30)groups. Pre- and post-operatively, the cognitive function was evaluated using the Montreal Cognitive Assessment(Mo CA)test and the changes in serum S100β and NSE levels were analyzed in the two groups. Results Compared to the preoperative levels, serum S100β and NSE levels in both groups significantly increased at the end of and 6 h and 12 h after surgery(P<0.05). Compared to that of the normal sleep group, there was no significant difference in the Mo CA scores in the SS group(P>0.05). However, levels of serum S100β were different preoperatively and at the end of and 6 h after surgery(P>0.05). NSE levels increased at the end of and 6 h and 12 h after surgery(P>0.05). Conclusion Patients with simple snoring after general anesthesia had impaired cognitive function, but the extent of cognitive impairment was was only reflected by serological changes.

Key words: General anesthesia, Cognitive function, S100β, Simple snoring, NSE

CLC Number: 

  • R766.7
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