Abstract: Objective To investigate the clinical effect of 25-gauge minimally invasive vitrectomy for treatment of rhegmatogenous retinal detachment. Methods This was a retrospective analysis of 52 patients with retinal detachment treated in our hospital. Patients were divided into treatment and control groups(n=26 each). The treatment group was treated with 25+ minimally invasive vitrectomy, and the control group was treated with 23G minimally invasive vitrectomy. The two groups were followed up for at least 3 months. The following parameters were evaluated: duration of the procedure, postoperative visual acuity, intraocular pressure, complications, and retinal restoration. Results The duration of the procedure in the treatment group was significantly shorter than that in the control group(P<0.05). Three and seven days following the operation, the intraocular pressure in both groups increased significantly. The postoperative logarithm of the minimum angle of resolution(LogMAR)visual acuity was significantly lower than the preoperative value(P<0.05). The incidence rate of complications in the treatment group was 15.38%, which was significantly lower than that in the control group(42.31%; P<0.05). The incidence rate of intraocular hypotension in the treatment group(3.85%)was significantly lower than that in the control group(30.77%)(P<0.05). There were no statistically significant differences in the retinal replacement rates between the treatment and control groups(92.31% and 88.46%, respectively; P>0.05). Conclusion Both 25-gauge and 23G minimally invasive vitrectomy have similar effectiveness in the treatment of rhegmatogenous retinal detachment, but the former is safer and is associated with a lower risk of postoperative complications and intraocular hypotension.

Key words: Vitreoretinal surgery, 25+, Intraocular hypotension, Clinical effect, Ruptural detachment of retina, 23G