Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (6): 16-20.doi: 10.6040/j.issn.1673-3770.0.2019.388

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Correlation between eosinophils and olfactory dysfunction in patients with CRSwNP after nasal operation

TAO Dandan, DONG Hongjun, CHU Yunfeng, HUANG Chao, HU Lei   

  1. Department of Otolaryngology, Zhangjiagang Traditional Chinese Medicine Hospital, Zhangjiagang 215600, Jiangsu, China
  • Published:2021-01-11

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Abstract: Objective To investigate the association between postoperative tissue eosinophils and olfactory dysfunction in patients with chronic rhinosinusitis and nasal polyps(CRSwNP). Methods A retrospective study of 120 patients who underwent CRSFNP endoscopic sinus surgery(ESS)between July 2016 and July 2018 was performed. The conditions of the patients were graded with the VAS and Lund-Kennedy scores; the eosinophil counts of the sinus mucosa were obtained. Olfactory function was assessed using the Sniffin' Sticks test and chemosensory event-related potential(CSERP). Spearman correlation analysis was used to determine the relationship between eosinophil count and the Sniffin' Sticks test results and CSERP parameters as well as the correlation between the VAS score and CSERP. Results The correlation analysis results after adjustment for covariates(age, gender, alcohol consumption, smoking, allergic rhinitis, asthma, postoperative time, and Lund-Kennedy score)were consistent with the results of the unadjusted covariates. The tissue eosinophil counts were associated with the threshold scores(r=-0.460, P=0.012): tissue eosinophil count and phenylethyl alcohol(N1: r=0.471, P=0.010; P2: r=-0.487, P=0.007)and ethanol(N1: r=-0.516, P=0.008; P2: r=-0.590, P=0.002). The peak latency of CSERP induced by stimulation was related to N1 and P2; however, it showed no significant correlation with the CSERP amplitude(P>0.05). There was a significant negative correlation between the threshold score generated by phenylethyl alcohol stimulation and the CSERP peak latency(N1: r=-0.560, P<0.001). There was a significant negative correlation between the CSERP latency generated by ethanol stimulation and the symptomatic VAS score(r=-0.400, P=0.005). Conclusions Postoperative tissue eosinophilia in patients with CRSwNP is significantly associated with postoperative olfactory disturbance, and the sensitivity of the trigeminal nerve may be associated with tissue eosinophilia. Inflammation of the nasal mucosa may affect the function of the olfactory and trigeminal nerves.

Key words: Chronic rhinosinusitis with nasal polyps, Eosinophil, Olfactory, Correlation

CLC Number: 

  • R765.4
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