Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 30-35.doi: 10.6040/j.issn.1673-3770.1.2022.572

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Research progress in biologic targeted drug therapy for chronic sinusitis

LIANG XuOverview,SHI Li   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, The Second Hospital of Shandong University, Jinan 250033, Shandong, China
  • Published:2022-06-15

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Abstract: Chronic sinusitis(CRS)is a chronic inflammatory disease of the nasal cavity and sinuses. Based on its pathogenesis, CRS can be divided into type 1, type 2, and type 3 inflammatory intrinsic type. At present, the drug therapy and surgical treatment of CRS have the risk of various adverse reactions and complications; among these cases of refractory sinusitis, some cannot achieve satisfactory results and are prone to recurrence despite appropriate drug and surgical treatment, thus seriously affecting the quality of life of patients. The application and development of biologic targeted drugs provide an effective and safe alternative to the treatment of CRS. This review focuses on the research progress of biologic targeted drug therapy targeting the cytokines associated with the three intrinsic types of CRS inflammation, including TNF-α, IL-4, IL-5, IL-13, IgE, and IL-17.

Key words: Sinusitis, Nasal polyps, Eosinophils, Inflammatory factor, Biologic targeted drug, Treatment

CLC Number: 

  • R765.41
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