Abstract: Objective To evaluate the clinical effect of optimal pulse technology combined with meibomian gland massage to treat meibomian gland dysfunction. Methods We performed a prospective analysis of 172 eyes of 86 patients with meibomian gland dysfunction from May to December 2019. The study population was randomly divided into observation and control groups, each including 86 eyes of 43 patients. All patients were treated with optimal pulse technology for a total of 4 times, once every 4 weeks. Patients in the observation group underwent meibomian gland massage after each treatment. The ocular surface disease index(OSDI)score, noninvasive tear break-up time(NITBUT), noninvasive tear meniscus height(NITMH), meibomian gland score(MGS), and meibomian gland yielding secretion score(MGYSS)were recorded before and after the first treatment. Results The indices recorded at each time point, except for NITMH and MGS, improved significantly(P<0.001). The OSDI score did not differ between the two groups at 4 weeks after the treatment(P=0.857)and was better in the observation group than in the control group at other time points(P_{8 weeks}=0.002, P_{12 weeks}=0.024, P_{16 weeks}<0.001). NITBUT was better in the observation group than in the control group at each time point(P<0.001; P_{4 weeks}<0.001, P_{8 weeks}=0.005, P_{12 weeks}=0.045, P_{16 weeks}=0.013). Conclusions The optimal pulse technology combined with meibomian gland massage can relieve symptoms, stabilize tear film, and reduce inflammation. The treatment effect is obvious.

Key words: Optimal pulse technology, Meibomian gland massage, Meibomian gland dysfunction, Treatment, Clinical effect