Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (5): 17-22.doi: 10.6040/j.issn.1673-3770.0.2020.379

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Application of decellularized dermal matrix after benign tumor resection in the nasal sinus

JIN Xin, SHI Lei, JIN Mengyuan   

  1. Department of Otorhinolaryngology, The First Hospital of China Medical University, Shenyang 110001, Liaoning, China
  • Published:2021-09-29

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Abstract: Objective This study aimed to observe and investigate the application of acellular dermal matrix in the nasal sinuses after resection of benign tumors of the nasal cavity and paranasal sinuses, mucosal morphology recovery, and epithelialization. It also compared and analyzed the patient's symptom scores and nasal endoscopy results for the mucous membrane, to evaluate the value of acellular dermal matrix in promoting functional repair and epithelialization of the postoperative nasal mucosa. Finally, it aimed to provide new ideas and methods of improving postoperative recovery of nasal endoscopy. Methods 32 Patients were randomly divided into the experimental group(with acellular dermal matrix)and the control group(without acellular dermal matrix). The Visual Analog Scale(VAS)score and Lund-Kennedy Score(LKES)at 1, 2, 4, and 12 weeks before and after surgery were determined for each of the two groups, and the clinical efficacy of the methods used in the two groups was compared. Results At 2 weeks after surgery, the recovery of the mucosa of the experimental group was significantly better than that of the control group(P<0.05). Regarding the separate signs, the LKES achieved by the experimental group was significantly lower than that achieved by the control group(P<0.05). At 12 weeks after surgery, the scar LKES of the experimental group was significantly lower than that of the control group(P<0.05). The rate of epithelialization in the experimental group was significantly higher than that in the control group(P<0.05). No complications occurred after the operation. The epithelialization rates were compared between the two groups at 4, 8, and 12 weeks. Conclusion Covering the acellular dermal matrix with mucosa in the operative area of benign tumors of the nasal cavity and paranasal sinuses resection can effectively promote the epithelialization of mucosa, accelerate the epithelialization, and improve the scab scar of the nasal mucosa, the symptoms of patients, and patients’ quality of life, which is worthy of clinical application.

Key words: Nasal sinuses benign tumor, Acellular dermal matrix, Repair, Epithelization, Observation of curative effect

CLC Number: 

  • R765.9
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