Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (5): 23-27.doi: 10.6040/j.issn.1673-3770.0.2020.536

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Serum 25-(OH)D3 and tissue TGF-β1 levels in patients with chronic rhino sinusitis with nasal polyps and their clinical significance

HAN Jiaqi, YUAN Guoqing, ZHU Yutong, JIANG Feifei, YAN Aihui   

  1. Department of Otolaryngology, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, China
  • Published:2021-09-29

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Abstract: Objective To investigate the relationship between serum 25-(OH)D3 levels and transforming growth factor-β1(TGF-β1)expression in patients with chronic rhinosinusitis with nasal polyps(CRSwNP). Methods Forty-seven patients with CRSwNP who were diagnosed by pathology were selected as an observation group and 21 patients with maxillary sinus cysts were selected as the control group. The level of serum 25-(OH)D3 and the mean optical density of TGF-β1 in the tissue samples were compared between the two factors. Results The level of serum 25-(OH)D3 in the observation group(16.97±7.35 μg/L)was lower than that in the control group(22.07±11.60 μg/L), the difference was statistically significant (P=0.032); the mean optical density of the TGF-β1 in the nasal polyps(0.052 4±0.019 1)was higher in the observation group than the control group(0.041 0±0.014 5); the difference was statistically significant(P=0.018). There was a significant correlation between serum 25-(OH)D3 levels and TGF-β1 expression in the nasal polyps(R2=0.204,|R|=0.452, P=0.019). Conclusion The level of serum 25-(OH)D3 in patients with CRSwNP decreased, while the expression of TGF-β1 in the nasal polyps increased, and there was a significant correlation between them in CRSwNP.

Key words: 25-(OH)D3, Transforming growth factor-β1, Chronic rhinosinusitis with nasal polyps, Chronic rhinosinusitis, Maxillary sinus cyst, Optical density value

CLC Number: 

  • R765.4
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